Results 41 to 50 of about 380,966 (308)

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Mycobacterium tuberculosis is less likely to acquire pathogenic mutations during latent infection than during active disease

Microbiology Spectrum
Most people infected with Mycobacterium tuberculosis (Mtb) are believed to be in a state of latent tuberculosis (TB) infection (LTBI). Although LTBI is asymptomatic and not infectious, there is a risk of developing active disease even decades after ...
Asami Osugi, Aki Tamaru, Takashi Yoshiyama, Tomotada Iwamoto, Satoshi Mitarai, Yoshiro Murase   +5 more
doaj   +1 more source

Adult‐Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe the case of a 41‐year‐old man diagnosed with adult‐onset subacute sclerosing panencephalitis (SSPE). The patient presented with subacute progressive cognitive deficits and a neuropsychological profile indicating predominant frontoparietal dysfunction. MRI showed only mild parietal‐predominant cerebral atrophy.
Dennis Yeow, Nicola McKern, Vincent Oxenham, Kate Ahmad, Omar Ahmad   +4 more
wiley   +1 more source

Risk factors, molecular analysis and treatment outcomes of amikacin-resistant Mycobacterium avium complex pulmonary disease

ERJ Open Research
Background Although the incidence of amikacin (AMK)-resistant Mycobacterium avium complex (MAC) pulmonary disease (PD) is suspected to have increased, limited data are available on AMK-resistant MAC-PD.
Tatsuya Kodama, Akio Aono, Keiji Fujiwara, Koji Furuuchi, Masashi Ito, Keisuke Kamada, Fumiya Watanabe, Kinuyo Chikamatsu, Yuriko Igarashi, Yoshiro Murase, Hideo Ogata, Yuji Shiraishi, Takashi Yoshiyama, Ken Ohta, Satoshi Mitarai, Kozo Morimoto   +15 more
doaj   +1 more source

Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis

mBio, 2020
Mycobacterium tuberculosis, which causes tuberculosis (TB), is estimated to infect one-third of the world’s population. The overall burden and the emergence of drug-resistant strains of Mycobacterium tuberculosis underscore the need for new therapeutic ...
Jeffrey Quigley, Aaron Peoples, Asel Sarybaeva, Dallas Hughes, Meghan Ghiglieri, Catherine Achorn, Alysha Desrosiers, Cintia Felix, Libang Liang, Stephanie Malveira, William Millett, Anthony Nitti, Baldwin Tran, Ashley Zullo, Clemens Anklin, Amy Spoering, Losee Lucy Ling, Kim Lewis   +17 more
doaj   +1 more source

Antimicrobial effects of folk medicinal plants from the North of Iran against Mycobacterium tuberculosis [PDF]

, 2015
Background: Medicinal plants have been used traditionally in Golestan province (north of Iran), against Mycobacterium tuberculosis or the clinical signs of tuberculosis (TB).
Davoodi, H., Ghaemi, E.A., Ghazisaidi, K., Jahanpour, N., Jahanpour, S., Mazandarani, M., Samet, M.   +6 more
core  

The transcriptome of Mycobacterium tuberculosis in a lipid-rich dormancy model through RNAseq analysis [PDF]

, 2017
Tuberculosis (TB) is currently the number one killer among infectious diseases worldwide. Lipids are abundant molecules during the infectious cycle of Mycobacterium tuberculosis (Mtb) and studies better mimicking its actual metabolic state during ...
Aguilar-Ayala, Diana, Deforce, Dieter, Gonzalez-Y-Merchand, Jorge A, Martin, Anandi, Palomino, Juan Carlos, Tilleman, Laurentijn, Van Nieuwerburgh, Filip, Vandamme, Peter   +7 more
core   +2 more sources

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Diferenciação de micobactérias por PCR multiplex Differentiation of micobacteria by multiplex PCR

Revista da Sociedade Brasileira de Medicina Tropical, 2009
O trabalho visou à otimização de um método baseado na reação em cadeia da polimerase multiplex - para diferenciação de micobactérias de interesse para a saúde pública.
Diogo da Rocha Poroca, Andrea Santos Lima, Juliana Falcão de Araújo Lima, Heidi Lacerda Alves da Cruz, Rosana de Albuquerque Montenegro, Fábio Lopes de Melo, Haiana Charifker Schindler, Lílian Maria Lapa Montenegro   +7 more
doaj   +1 more source

Flow cytometric detection of gamma interferon can effectively discriminate Mycobacterium bovis BCG-vaccinated cattle from M. bovis-infected cattle [PDF]

, 2006
Mycobacterium bovis is the causative agent of bovine tuberculosis, a disease that is increasing in incidence in United Kingdom cattle herds. In addition to increasing economic losses, the rise in bovine tuberculosis poses a human health risk. There is an
Hope, J C, Howard, C J, Sopp, P
core   +2 more sources