Adjuvant activity of Mycobacteria-derived mycolic acids [PDF]
Heliyon, 2020 Successful vaccination, especially with safe vaccines such as component/subunit vaccines, requires proper activation of innate immunity and, for this purpose, adjuvant is used.
Mio Kubota +5 more
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MmpL3 is the flippase for mycolic acids in mycobacteria. [PDF]
Proc Natl Acad Sci U S A, 2017 Abstract The defining feature of the mycobacterial outer membrane (OM) is the presence of mycolic acids (MAs), which in part render the bilayer extremely hydrophobic and impermeable to external insults, including many antibiotics.
Xu Z, Meshcheryakov VA, Poce G, Chng SS.
europepmc +6 more sources
Ion mobility mass spectrometry for the study of mycobacterial mycolic acids [PDF]
Scientific Reports, 2023 Lipids are highly structurally diverse molecules involved in a wide variety of biological processes. The involvement of lipids is even more pronounced in mycobacteria, including the human pathogen Mycobacterium tuberculosis, which produces a highly ...
Yi Liu +4 more
doaj +2 more sources
In vivo imaging of MmpL transporters reveals distinct subcellular locations for export of mycolic acids and non-essential trehalose polyphleates in the mycobacterial outer membrane [PDF]
Scientific Reports, 2023 The mycobacterial cell envelope consists of a typical plasma membrane, surrounded by a complex cell wall and a lipid-rich outer membrane. The biogenesis of this multilayer structure is a tightly regulated process requiring the coordinated synthesis and ...
Laurie Thouvenel +4 more
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Identification of Mycobacteria by Thin Layer Chromatographic Analysis of Mycolic Acids and Conventional Biochemical Method: Four Years of Experience [PDF]
Memorias do Instituto Oswaldo Cruz, 1998 Mycolic acids analysis by thin-layer chromatography (TLC) has been employed by several laboratories worldwide as a method for fast identification of mycobacteria.
Clarice Queico Fujimura Leite +2 more
doaj +3 more sources
Conformational Dynamics and Stability of Bilayers Formed by Mycolic Acids from the Mycobacterium tuberculosis Outer Membrane [PDF]
Molecules, 2023 Bilayers of mycolic acids (MAs) form the outer membrane of Mycobacterium tuberculosis that has high strength and extremely low permeability for external molecules (including antibiotics).
Liana A. Savintseva +10 more
doaj +2 more sources
Synthesis of a Di-Mycoloyl Tri-Arabinofuranosyl Glycerol Fragment of the Mycobacterial Cell Wall, Based on Synthetic Mycolic Acids [PDF]
Molecules, 2019 Fragments of mycobacterial cell walls such as arabinoglycerol mycolate and dimycoloyl diarabinoglycerol, comprising complex mixtures of mycolic acids, have immunostimulatory and antigenic properties.
Omar T. Ali +3 more
doaj +2 more sources
Detection and accurate identification of Mycobacterium species by flow injection tandem mass spectrometry (FIA-MS/MS) analysis of mycolic acids [PDF]
Scientific ReportsMycolic acids, long-chain α-alkyl, β-hydroxy fatty acids, are characteristic for the genus Mycobacterium and play a critical role in the structural integrity and pathogenicity of mycobacterial cell walls.
Szewczyk Rafał +4 more
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Arabino mycolates from synthetic mycolic acids [PDF]
Tetrahedron, 2016 Abstract The synthesis of single mono-arabino mycolates, important lipid antigens from mycobacteria is described, using structurally defined synthetic mycolic acids. Preliminary assays indicate that these are differentially antigenic to antibodies in the serum of people with active tuberculosis.
Mohsin O. Mohammed +4 more
openalex +4 more sources
Killing of Mycolic Acid-Containing Bacteria Aborted Induction of Antibiotic Production by Streptomyces in Combined-Culture. [PDF]
PLoS ONE, 2015 Co-culture of Streptomyces with mycolic acid-containing bacteria (MACB), which we termed "combined-culture," alters the secondary metabolism pattern in Streptomyces and has been a useful method for the discovery of bioactive natural products.
Shumpei Asamizu +4 more
doaj +3 more sources