Results 171 to 180 of about 123,738 (330)

Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes. [PDF]

, 2019
The germinal center (GC) is the anatomical site where humoral immunity evolves. B cells undergo cycles of proliferation and selection to produce high-affinity Abs against Ag. Direct linkage of a TLR9 agonist (CpG) to a T-dependent Ag increases the number
Ansel, K Mark, DeFranco, Anthony L, Wigton, Eric J   +2 more
core   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

Immunity, 1998
O. Adachi, T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M. Sakagami, K. Nakanishi, S. Akira   +7 more
semanticscholar   +1 more source

Solamargine induces acute myeloid leukemia differentiation through TLR8 activation

VIEW, EarlyView.
SM, a steroidal alkaloid from Solanum nigrum L. has shown anticancer effect on various kinds of human cancer cells, yet its effect on leukemia cells remains unclear. This study examines antileukemic activities of SM in AML cells. Results indicate SM inhibits growth and promotes apoptosis of AML cells.
Qiaoyan Han, Yuting Chen, Zheyi Li, Yonglin Peng, Zhehan Hu, Yuliang Deng, Yanli Fu, Ming Cheng, Sheng Tan, Jing Tian, Xiaodong Zhao, Miao Sun   +11 more
wiley   +1 more source

Rapidly Progressive Cutaneous Nodules in an Elderly Woman

JEADV Clinical Practice, EarlyView.
Valeria Olvera‐Rodriguez, Gerardo González‐Martínez, Marion Carolina Alemán‐Jiménez, Minerva Gómez‐Flores, Jorge Ocampo‐Candiani, Lucía T. Fernández   +5 more
wiley   +1 more source

Integrating mass spectrometry and systems biology for the modernization of natural medicines: From deciphering chemical complexity to holistic efficacy assessment

VIEW, EarlyView.
This review explores how mass spectrometry is transforming research in natural medicines, with Traditional Chinese medicine (TCM) as a primary exemplar. It details the application of advanced mass spectrometry in chemical analysis, the development of comprehensive quality control methods, and systematic research on the targeted mechanisms of single ...
Yudian Xu, Linlin Cao, Chenhuan Ding, Chen Wang, Yi Lai, Dan Ru, He Li, Wei Xu   +7 more
wiley   +1 more source

MyD88 and Its Inhibitors in Cancer: Prospects and Challenges

Biomolecules
The interplay between the immune system and cancer underscores the central role of immunotherapy in cancer treatment. In this context, the innate immune system plays a critical role in preventing tumor invasion.
Jiali Song, Yuying Li, Ke Wu, Yan Hu, Luo Fang   +4 more
doaj   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Genetic engineering for SIT application: a fruit fly‐focused review

Insect Science, EarlyView.
Abstract Sterile insect technique (SIT) has become a key component of efficient pest control. Fruit fly pests from the Drosophilidae and Tephritidae families pose a substantial and overwhelmingly increasing threat to the agricultural industry, aggravated by climate change and globalization among other contributors.
Serafima Davydova, Danheng Yu, Angela Meccariello   +2 more
wiley   +1 more source

Presenting Clinical Features of Vitreoretinal Lymphoma

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Vitreoretinal lymphoma is a rare cancer, widely recognised to present diagnostic challenges. We aimed to report information that would support the clinician in considering this diagnosis. Methods We interrogated the International Vitreoretinal B‐Cell Lymphoma Registry for clinical data from patients newly diagnosed with ...
The International Vitreoretinal B‐Cell Lymphoma Registry Investigator Group, Mara Albert‐Fort, Sofia Androudi, Neni Anggraini, Atitaya Apivatthakakul, J. Fernando Arevalo, Meghan K. Berkenstock, Ester Carreño, Anita S.Y. Chan, Soon‐Phaik Chee, Fred K. Chen, Janejit Choovuthayakorn, Luca Cimino, Elisa E. Cornish, Gábor G. Deák, Alexandra L. Farrall, Christina J. Flaxel, Marion Funk, Zsuzsanna Gehl, Pietro Gentile, Debra A. Goldstein, John A. Gonzales, Fabrizio Gozzi, Antonio Hernández‐Pons, Samar Issa, Timothy M. Janetos, Hyeong Min Kim, Min Kim, Jared E. Knickelbein, Zachary A. Kroeger, Paradee Kunavisarut, Rina La Distia Nora, Seung Min Lee, Lyndell L. Lim, Ming Lee Lin, Victor Llorenç, Yunhua Loo, Lucía Martínez‐Costa, Janet M. Matthews, Peter J. McCluskey, David L. McKay, Matteo Menean, Elisabetta Miserocchi, Manabu Mochizuki, Rachael L. Niederer, Roderick F. O’day, Amy S. Pai, Alan G. Palestine, Kessara Pathanapitoon, Mark H.B. Radford, Josephine Richards, Sukhum Silpa‐archa, Joanne L. Sims, Justine R. Smith, Robert T. Swan, Yukiko Terada, Daniel V. Vasconcelos‐Santos, Anagha Vaze, Samanthila Waduthantri, Travers R.E. Weaver, Keryn L. Williams, Se Joon Woo, Richard J. Woodman, Frances Wu, Christine Younan   +64 more
wiley   +1 more source