Results 201 to 210 of about 103,309 (254)

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Enhanced Epigenetic Modulation via mRNA-Encapsulated Lipid Nanoparticles Enables Targeted Anti-inflammatory Control. [PDF]

ACS Synth Biol
Mokhtari T, Taheri MN, Akhlaghi S, Aryannejad A, Xiang Y, Mahajan V, Keshavarz K, Kiani A, Yang S, LoPresti S, LeGraw R, Whitehead KA, Kiani S.   +12 more
europepmc   +1 more source

Rab43 mitigates the inflammatory response in acute lung injury via MyD88 ubiquitination. [PDF]

Sci Rep
Wang Y, Liu X, Zhu Z, Wu D, Chen Y, Gong D, Wu P, Qian H, He B, Wang G.   +9 more
europepmc   +1 more source

Systems-Level Analysis of HPAI H5N1 Infection in Ducks: Integrating Transcriptomic, Proteomic, and Phosphoproteomic Data. [PDF]

Int J Mol Sci
Vijayakumar P, Mishra A, Rajamanickam K, Raut AA.   +3 more
europepmc   +1 more source

Treatment initiation by positive liquid biopsy alone in primary central nervous system lymphoma: A retrospective analysis of a multi-institutional study. [PDF]

Neurooncol Adv
Mitobe M, Shibuma S, Takahashi H, On J, Takino T, Kawabe K, Mouri Y, Kumagai S, Kozakai T, Momoi A, Suzuki N, Fukushima T, Suzuki T, Kuroda H, Saji E, Nakamura K, Hashidate H, Nakahara A, Tomita T, Watanabe J, Tsukamoto Y, Okada M, Hiraishi T, Yamashita S, Akai T, Kuroda S, Kakita A, Sone H, Takizawa J, Oishi M, Natsumeda M.   +30 more
europepmc   +1 more source

Atg5 regulates formation of MyD88 condensed structures and MyD88-dependent signal transduction.

Atg5 regulates formation of MyD88 condensed structures and MyD88-dependent signal transduction.
MyD88 is known as an essential adaptor protein for Toll-like receptors (TLRs). Previous studies have shown that transfected MyD88 forms condensed structures in the cytoplasm. However, upon TLR stimulation, there is little formation of endogenous MyD88 condensed structures. Thus, the formation of MyD88 condensed structures is tightly suppressed, but the
openaire  

Inhibition of TLR4 enhances oxaliplatin chemotherapy sensitivity in esophageal squamous cell carcinoma by suppressing inflammation and glycolysis. [PDF]

BMC Gastroenterol
Zhu Z, Zhang M, Di Z, Tao X, Dai Y, Zhan Z, Chen H.   +6 more
europepmc   +1 more source

Activating MYD88 Gene Mutation [PDF]

, 2020
openaire   +1 more source

MyD88 signaling in myeloid cells induces gastrointestinal tract injury and systemic inflammation after West Nile virus infection. [PDF]

Cell Rep
Lin SC, Zhao FR, Mack M, Mbalaviele G, Diamond MS.   +4 more
europepmc   +1 more source

Ningxiang pig-derived Enterococcus hirae protects against E. coli-induced gut dysbiosis and inflammation via acetate/propionate-MyD88-NF-κB axis in piglets. [PDF]

Microbiome
Zhang L, Wu Z, Shen H, Meng Y, Li H, Cai R, Tang D, Kang M, Yin Y, Tan B, Wang J.   +10 more
europepmc   +1 more source