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MYD88 L265P mutation in Waldenstrom macroglobulinemia
Blood, 2013Key Points The MYD88 locus is altered in 91% of patients with WM. MYD88 might be new target for therapeutic in WM.
Nathalie Grardel +2 more
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MyD88 is a mediator for the activation of Nrf2
Biochemical and Biophysical Research Communications, 2011If not controlled properly, inflammatory response is often detrimental. However, in many cases, it can be self-limited and subsides without inflicting tissue damage. In this study, we tested the hypothesis that inflammatory stimuli can trigger anti-inflammatory response, which may contribute to limiting tissue damage induced by excessive inflammation ...
Kyun Ha, Kim +7 more
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Mighty MyD88 in Health and Disease
Retina, 2016In 2012, Treon et al,1 in their study of patients with IgM lymphoplasmacytic lymphoma and the associated clinical syndrome Waldenstrom macroglobulinemia (WM), found that a single nucleotide somatic mutation in the myeloid differentiation primary response 88 (MYD88) gene, leading to ...
Jose S, Pulido +4 more
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Science's STKE, 2000
Toll receptors are activated by bacterially produced pathogen-associated molecular pattern (PAMPs). Bacterial lipoproteins (BLPs) are PAMPs that activate the Toll-like receptor 2 (TLR2) through recruitment of the adaptor molecule MyD88. Transfection of a variety of dominant negative mutants allowed Aliprantis et al
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Toll receptors are activated by bacterially produced pathogen-associated molecular pattern (PAMPs). Bacterial lipoproteins (BLPs) are PAMPs that activate the Toll-like receptor 2 (TLR2) through recruitment of the adaptor molecule MyD88. Transfection of a variety of dominant negative mutants allowed Aliprantis et al
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Nature Immunology, 2006
The adaptor protein MyD88 is involved in interleukin 1 receptor and Toll-like receptor signaling. Unexpectedly, new evidence shows that MyD88 also participates in interferon-γ-induced cellular responses.
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The adaptor protein MyD88 is involved in interleukin 1 receptor and Toll-like receptor signaling. Unexpectedly, new evidence shows that MyD88 also participates in interferon-γ-induced cellular responses.
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Evolutionary and functional analysis of MyD88 genes in pearl oyster Pinctada fucata martensii
Fish and Shellfish Immunology, 2020Yu Jiao, Yuewen Deng
exaly
IRF1 negatively regulates NF-κB signaling by targeting MyD88 for degradation in teleost fish
Developmental and Comparative Immunology, 2020Xuezhu Liu, Tianjun Xu
exaly
MyD88-Dependent Glucose Restriction and Itaconate Production Control Brucella Infection
Infection and Immunity, 2021Jerod Skyberg, Alexis S Dadelahi
exaly