Results 241 to 250 of about 76,910 (294)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, Volume 7, Issue 3, Page 99-108, September 2026.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

MyD88 mediates allergic airway inflammation by regulating ILC2s function through inducing the formation of P38/GATA3 complex. [PDF]

Respir Res
Zhang H, Dai W, Chen X, Xi X, Chen Y, Song J, Ge X, Xiang Q, Zhang B, Zhao C, Zhang W, Zhang Y.   +11 more
europepmc   +1 more source

FADD Protein for the Early Diagnosis of Rheumatoid Arthritis

ACR Open Rheumatology, Volume 8, Issue 9, September 2026.
Objective FADD (Fas‐Associated Death Domain) protein in patients’ serum and synovial fluid could be a biomarker of inflammation in rheumatic diseases. We tested whether the baseline serum FADD level would be a predictive factor for meeting the American College of Rheumatology (ACR)/EULAR 2010 criteria for rheumatoid arthritis (RA) in order to ...
Géraldine Falgarone, Sara Mouasni, Sylvie Mistou, Valérie Devauchelle‐Pensec, Jacques‐Eric Gottenberg, Gilles Chiocchia, Léa Tourneur   +6 more
wiley   +1 more source

[Electroacupuncture ameliorates cognitive impairment and suppresses TLR4/MyD88/NF-κB pathway-mediated astrocyte activation in rats with vascular dementia]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Gao J, Shi C, Li W, Shang X, Wang F, Yang Q, Li F.   +6 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Potential role of tirabrutinib as part of an optimal treatment strategy for lymphomatosis cerebri: illustrative case. [PDF]

J Neurosurg Case Lessons
Ono M, Inoue A, Miyazaki Y, Nakamura Y, Ohno T, Taniwaki M, Yano H, Watanabe H, Kunieda T.   +8 more
europepmc   +1 more source

Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Chronic diabetic wounds are hindered by a “dual trap” of biofilm resistance and hyperinflammation. A mesoporous catalytic‐adsorptive nano‐regulator is developed to dismantle this barrier through simultaneous eDNA degradation and LPS sequestration. By silencing TLR4/9‐mediated signaling, the platform clears resilient pathogens and reprograms the immune ...
Junfeng Song, Yang Song, Xirui Huang, Xingjin Li, Lifei Gao, Yixiang Wang, Tianbao Zhu, Xiaomin Li, Shuai Wang, Tiancong Zhao, Dongyuan Zhao   +10 more
wiley   +1 more source

Phosphoregulation of interleukin-1 receptor-associated kinase 1 in inflammatory signaling. [PDF]

Front Immunol
Suresh M, Vaz CE, Dcunha L, Raju R, Pinto SM, Kanekar S.   +5 more
europepmc   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Clonotypic characterization defines B-cell drivers of clonal expansion and intratumor heterogeneity in IgM monoclonal gammopathies. [PDF]

Hemasphere
Moreno DF, Nadeu F, Casado-Peláez M, Mata C, Márquez-López I, Fernández MA, Vaqué S, Medina E, Llobregat H, Garrote M, Mañé J, Cardús O, Rodríguez-Lobato LG, de Daniel A, Cibeira MT, Gremen Oliveira T, Kulaeva E, Lozano E, Colomer D, Rosiñol L, van Boxtel R, Esteller M, Fernández de Larrea C.   +22 more
europepmc   +1 more source