Results 91 to 100 of about 8,110,219 (215)

Glycoproteins associated with myelin in the central nervous system.

, 1981
Purified myelin fractions from the central nervous system contain one major myelin-associated glycoprotein and approximately 16 minor glycoproteins.
Matthieu JM
core   +1 more source

A Tripartite Model for EBV‐Driven Multiple Sclerosis: B Cell Survival, Altered Self‐Presentation, and HLA‐DR15‐Restricted T Cell Cross‐Reactivity

iNew Medicine, EarlyView.
ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu, Arnaud John Kombe Kombe, Tengchuan Jin   +2 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Endogenous Activation of mGlu5 Metabotropic Glutamate Receptors Is Required for Oligodendrocyte Maturation and Myelinogenesis in Mice

Cells
mGlu5 metabotropic glutamate receptors are highly expressed and functional in early postnatal life, but their role in brain development remains to be elucidated.
Roxana Paula Ginerete, Roberta Facchinetti, Alessia Ceccherelli, Giada Mascio, Sara Rubio Casado, Luisa Di Menna, Sonia Castaldi, Matteo Caridi, Valeria Bruno, Ferdinando Nicoletti, Giuseppe Battaglia, Caterina Scuderi, Rosamaria Orlando   +12 more
doaj   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder

, 2015
Pelizaeus-Merzbacher disease is an X-linked hypomyelinating leukodystrophy caused by mutations or rearrangements in PLP1. It presents in infancy with nystagmus, jerky head movements, hypotonia and developmental delay evolving into spastic tetraplegia ...
Meiner, Vardiella, Peles, Elior, Elazar, Nimrod, Schueler-Furman, Ora, Goldberg, Sharon, Schaeren-Wiemers, Nicole, Eshed-Eisenbach, Yael, Zimmerman, Bat-El, Mor, Nofar, Glick, Benjamin, Ponger, Penina, Harel, Michal, Lerer, Israela, Geiger, Tamar, Fellig, Yakov, Lossos, Alexander, Newman, J. P., Gomori, John M., Marreed, Hodaifah, Steck, Andreas J., Dotan, Shlomo, Azulay, Haim   +21 more
core   +1 more source

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Case report: Concurrent MOG antibody-associated disease and latent infections in two patients

Frontiers in Immunology
ObjectivesMyelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is frequently preceded by infections. The underlying pathomechanism, however, remains poorly understood. Here, we present the clinical data of two MOGAD patients with
Laila Kulsvehagen, Laila Kulsvehagen, Tim Woelfle, Tim Woelfle, Ana Beatriz Ayroza Galvão Ribeiro Gomes, Ana Beatriz Ayroza Galvão Ribeiro Gomes, Ana Beatriz Ayroza Galvão Ribeiro Gomes, Patrick Lipps, Patrick Lipps, Tradite Neziraj, Tradite Neziraj, Julia Flammer, Julia Flammer, Karoline Leuzinger, Tobias Derfuss, Tobias Derfuss, Jens Kuhle, Jens Kuhle, Athina Papadopoulou, Athina Papadopoulou, Anne-Katrin Pröbstel, Anne-Katrin Pröbstel   +21 more
doaj   +1 more source

Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1

Muscle &Nerve, EarlyView.
ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno, Mohammad Nazim, Ruchen Zhang, Paniz Farshadyeganeh, Mikako Ito, Bisei Ohkawara   +5 more
wiley   +1 more source

Myelin-associated glycoprotein and myelin basic protein are present in central and peripheral nerve myelin throughout phylogeny.

, 1986
This phylogenetic study of central and peripheral nervous system myelin proteins demonstrates that important changes occur in the composition of certain myelin proteins during evolution.
Eschmann N, Matthieu JM, Waehneldt TV
core   +1 more source