Results 71 to 80 of about 8,110,219 (215)

Bilateral pediatric myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) optic neuritis: a case report

Optic neuritis (ON) is defined as an acquired disorder of the optic nerve that may be associated with demyelinating diseases or infectious or inflammatory processes.
Wan Mahmud Sabri, Wan Muhammad Najib, Rosli, Abdul Hadi, Jabbari, Aidila Jesmin, Abd Bari, Muhd Syafi, Ahmad Fauzi, Nadhirah   +4 more
core   +1 more source

Myelination and axonal regeneration in the central nervous system of mice deficient in the myelin-associated glycoprotein.

, 1996
The myelin-associated glycoprotein, a member of the immunoglobulin superfamily, has been implicated in the formation and maintenance of myelin sheaths.
Bartsch U
core   +1 more source

Characteristics of myelin oligodendrocyte glycoprotein antibody-associated meningoencephalitis

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Background Meningoencephalitis can occur in myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD). Objective To assess the clinical and radiologic features of MOG-IgG meningoencephalitis.
Aisha Elfasi, Samir Alkabie, Elsa Rodriguez, Mayra Montalvo, Rhaisa Castrodad-Molina, Fernando X Cuascut, George J Hutton, Revere Kinkel, Jennifer Graves, Torge Rempe   +9 more
doaj   +1 more source

MOG-IgG-associated encephalitis and bronchopneumonia in a child with negative infection screening: a case report and literature review

Frontiers in Pediatrics
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorder (MOGAD) is a central nervous system demyelinating disease in children, frequently induced by infection.
Yan Sun, Xin Dong, Mingyue Sun, Fei Wang, Qing-Qing Yu, Yibing Yan, Na Cheng   +6 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog [PDF]

, 2006
We show that desert hedgehog ( dhh), a signaling molecule expressed by Schwann cells, is essential for the structural and functional integrity of the peripheral nerve.
Umehara, F, Meier, C, Turmaine, M, Jessen, KR, Sharghi-Namini, S, Sahni, V, Mirsky, R   +6 more
core  

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

The Clinical and Radiologic Features of Patients with Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-Associated Disease (MOGAD) in the City of Sakarya, Türkiye

Gazi Medical Journal
Objective: The study aims to share our knowledge on myelin oligodendrocyte glycoprotein antibody (anti-MOG) seropositivity in patients with demyelinating diseases, focusing on their clinical, serologic, and radiologic characteristics, as well as ...
Saadet Sayan, Esen Çiçekli, Onur Taydaş, Mohammadreza Yousefi, Tansu Doran, Dilcan Kotan   +5 more
doaj   +1 more source

Immunization with recombinant Nogo-66 receptor (NgR) promotes axonal regeneration and recovery of function after spinal cord injury in rats

Neurobiology of Disease, 2008
Nogo-66 receptor (NgR), a common receptor for the three known myelin-associated inhibitors, i.e., Nogo-A, myelin-associated glycoprotein (MAG), and oligodendrocyte myelin glycoprotein (OMgp), plays a key role in the failure of axonal regeneration in the ...
Panpan Yu, Lidong Huang, Jian Zou, Zhihua Yu, Yanxia Wang, Xiaofei Wang, Liang Xu, Xinqiu Liu, Xiao-Ming Xu, Pei-Hua Lu   +9 more
doaj   +1 more source