Results 21 to 30 of about 8,110,219 (215)

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Coffey, P, Baker, MD, Coffey Pete, Jackson, SJ, Gavin Giovannoni, Baker David, Samuel J. Jackson (468645), Zubair Ahmed (9352), Jackson Samuel J., Zubair Ahmed, Ahmed, Z, Mark D Baker, Pete Coffey (422262), David Baker, Samuel J Jackson, Gavin Giovannoni (125820), Giovannoni Gavin, Munro Peter, Ahmed Zubair, Pete Coffey, David Baker (11642), Peter Munro (479715), Peter Munro, Lidster Katie, Baker Mark D., Baker, D, Lidster, K, Mark D. Baker (146531), Katie Lidster, Munro, P, Katie Lidster (479714), Giovannoni, G   +31 more
core   +1 more source

Myelin-oligodendrocyte glycoprotein antibody-associated disease [PDF]

, 2021
Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently identified autoimmune disorder that presents in both adults and children as CNS demyelination.
Paul, F., Kim, H.J., Jacob, A., Tintore, M., Marignier, R., Hemmer, B., Kleiter, I., Reindl, M., Traboulsee, A., Pittock, S., Brilot, F., Stankoff, B., Amato, M.-P., Siva, A., Hacohen, Y., De Sèze, J., Selmaj, K., Alexopoulos, H., Banwell, B., Petzold, A., Vukusic, S., Sato, D.K., Waters, P., Weinshenker, B., Waubant, E., Cobo-Calvo, A., Linington, C., Derfuss, T., Asgari, N., Bennett, J., Pröbstel, A.-K., Aktas, O., Fujihara, K., Palace, J., Capobianco, M., Deiva, K., Leite, M.-I., Ciccarelli, O., Lassmann, H., Meinl, E., Chitnis, T.   +40 more
core   +5 more sources

Transverse myelitis in myelin oligodendrocyte glycoprotein antibody-associated disease

Frontiers in Neurology, 2023
Transverse myelitis (TM) is the second most common presentation of myelin oligodendrocyte antibody-associated disease (MOGAD), occurring in approximately 26% of affected patients.
Gina Perez-Giraldo, Natalia Gonzalez Caldito, Elena Grebenciucova   +2 more
doaj   +1 more source

Progressive myelin oligodendrocyte glycoprotein-associated demyelination mimicking leukodystrophy [PDF]

, 2022
Background: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with relapsing disease, but clinical progression independent of relapse activity is rare.
Jacob, Anu, Rathi, Nitika, Avula, Shivaram, Elhadd, Kariem, Huda, Saif, Gibbons, Emily, Whittam, Daniel, Griffiths, Michael, Bhojak, Maneesh   +8 more
core   +1 more source

Anti-myelin-associated-glycoprotein neuropathy successfully treated with tirabrutinib

Heliyon, 2022
Background: Anti-myelin-associated-glycoprotein (MAG) neuropathy is a distal, predominantly demyelinating, sensory or sensory-motor polyneuropathy most often developing in the context of an IgM-type monoclonal gammopathy due to monoclonal gammopathy of ...
Hajime Yasuda, Yuji Tomizawa, Sakiko Harada, Makoto Sasaki, Norio Komatsu, Jun Ando, Nobutaka Hattori, Miki Ando   +7 more
doaj   +1 more source

A rare presentation of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) as acute hemorrhagic longitudinally extensive transverse myelitis

The Egyptian Journal of Radiology and Nuclear Medicine, 2023
Background Myelin oligodendrocyte glycoprotein antibody-associated disease is usually associated with optic neuritis, acute disseminated encephalomyelitis or transverse myelitis.
Aniket Nerlekar, Sharad Malvadkar, Dhairyasheel Patil, Bhagyashree Bhoir, Neha Shaikh, Jagdish Sambare   +5 more
doaj   +1 more source

Cleavage of myelin associated glycoprotein by matrix metalloproteinases [PDF]

Journal of Neuroimmunology, 2008
Derivative myelin associated glycoprotein (dMAG) results from proteolysis of transmembrane MAG and can inhibit axonal growth. We have tested the ability of certain matrix metalloproteinases (MMPs) elevated with inflammatory and demyelinating diseases to cleave MAG. We show MMP-2, MMP-7 and MMP-9, but not MMP-1, cleave recombinant human MAG. Cleavage by
Milward, Elizabeth, Kim, Kee Jun, Griffin, John W., Calabresi, Peter A., Conant, Katherine, Szklarczyk, Arek, Nguyen, Thien, Melli, Giorgia, Nayak, Mamatha, Deshpande, Deepa, Fitzsimmons, Chantel, Hoke, Ahmet, Kerr, Douglas   +12 more
openaire   +2 more sources

MAG, myelin and overcoming growth inhibition in the CNS.

Frontiers in Molecular Neuroscience, 2015
While neurons in the central nervous system have the capacity to regenerate their axons after injury, they fail to do so, in part because regeneration is limited by growth inhibitory proteins present in CNS myelin.
Lisa eMcKerracher, Lisa eMcKerracher, Kenneth M Rosen   +2 more
doaj   +1 more source

Myelin oligodendrocyte glycoprotein antibody-associated disease manifesting as intractable fever managed by bromocriptine: a case report [PDF]

Journal of Neurocritical Care, 2023
Background Demyelinating events expressed as abnormal thermoregulatory responses are rare, but intractable fever in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is very rarely reported. Case Report A 56-year-old woman presented
Jin San Lee, Sukyoon Lee, Seong-il Oh
doaj   +1 more source

Functional role of the overexpression of the myelin and lymphocyte protein MAL in Schwann cells [PDF]

, 2013
For fast propagation of action potentials in the nervous system, higher vertebrates have developed a specialized plasma membrane structure, the myelin, ensheathing nerve fibers. Myelin sheaths are formed by Schwann cells in the peripheral nervous system (
Schmid, Daniela
core   +1 more source