Results 31 to 40 of about 8,110,219 (215)

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: an update

, 2022
Myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-associated optic neuritis has been established as a new entity of immune-mediated optic neuropathy. Patients usually present with recurrent optic neuritis, often bilaterally with initially severe
Vanessa Daccach Marques (5645420), Katharina Messias (5765279), Andre Messias (198395)   +2 more
core   +1 more source

Distinct serum and cerebrospinal fluid cytokine and chemokine profiles in autoantibody-associated demyelinating diseases

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019
Background Demyelinating diseases of the central nervous system associated with autoantibodies against aquaporin-4 and myelin-oligodendrocyte-glycoprotein are mediated by different immunopathological mechanisms compared to multiple sclerosis.
Livia S Hofer, Sara Mariotto, Sebastian Wurth, Sergio Ferrari, Chiara R Mancinelli, Rachele Delogu, Salvatore Monaco, Alberto Gajofatto, Carmen Schwaiger, Kevin Rostasy, Florian Deisenhammer, Romana Höftberger, Thomas Berger, Markus Reindl   +13 more
doaj   +1 more source

Two case reports and a systematic review of the literature on adult cerebral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein antibody

Frontiers in Immunology, 2023
Background and purposeMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has gained recognition in recent years as an immune-mediated inflammatory demyelinating disease of the central nervous system.
Meihui Xu, Chi Ma, Ming Dong, Chunjie Guo, Simin Yang, Yue Liu, Xu Wang   +6 more
doaj   +1 more source

Humoral response against myelin associated glycoprotein reflects oligodendroglial degeneration in Parkinson’s disease [PDF]

, 2016
Introduction Identification of disease-specific diagnostic and prognostic biomarkers which would enable early detection and follow-up of Parkinson’s disease (PD) is a crucial problem.
Konrad Rejdak, Papuc, E., Ewa Papuć, Wilczynska, B., Barbara Wilczyńska, Rejdak, K.   +5 more
core   +2 more sources

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: an update

, 2023
Myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-associated optic neuritis has been established as a new entity of immune-mediated optic neuropathy. Patients usually present with recurrent optic neuritis, often bilaterally with initially severe
Vanessa Daccach Marques (5645420), Katharina Messias (5765279), Andre Messias (198395)   +2 more
core   +1 more source

Widening of myelin lamellae in polyneuropathy with immunoglobulin-M monoclonal gammopathy, without activity against myelin-associated glycoprotein, responsive to treatment

, 2022
International audienceWe report the case of a patient with a very severe predominantly demyelinating sensorimotor polyneuropathy (with axonal loss) that had developed over several months, along with an immunoglobulin-M monoclonal gammopathy without anti ...
Vallat, Jean-Michel, Richard, Laurence, Devaux, Jérôme J., Mathis, Stéphane, Deschamps, Nathalie, Magy, Laurent   +5 more
core   +1 more source

Cytoplasmic domains of the myelin-associated glycoprotein

, 2000
Abstract The function of the vertebrate nervous system is based on the rapid and accurate transmission of electrical impulses. The myelin sheath is a lipid-rich membrane that envelops the axon, preventing the leakage of the nervous impulse to the environment. Myelin is formed when the plasma membrane of a myelinating glial cell differentiates and wraps
Kursula, P. (Petri)
openaire   +2 more sources

Structural basis of myelin-associated glycoprotein adhesion and signalling

Nature Communications, 2016
Myelin-associated glycoprotein (MAG) maintains myelin-axon spacing. Here, the authors report the crystal structures of the MAG full ectodomain in complex with oligosaccharide, and use additional assays to provide insights into the mechanism of MAG ...
Matti F. Pronker, Suzanne Lemstra, Joost Snijder, Albert J. R. Heck, Dominique M. E. Thies-Weesie, R. Jeroen Pasterkamp, Bert J. C. Janssen   +6 more
doaj   +1 more source

Proteasome Biology Is Compromised in White Matter After Asphyxic Cardiac Arrest in Neonatal Piglets

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Neurological deficits in hypoxic‐ischemic encephalopathy, even with therapeutic hypothermia, are partially attributed to white matter injury. We theorized that proteasome insufficiency contributes to white matter injury.
Polan T. Santos, Caitlin E. O'Brien, May W. Chen, C. Danielle Hopkins, Shawn Adams, Ewa Kulikowicz, Rashmi Singh, Raymond C. Koehler, Lee J. Martin, Jennifer K. Lee   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source