Results 131 to 140 of about 294,817 (379)

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J. Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L. Mangal, Abhirami P. Suresh, Niveda M. Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D. Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E. Stabenfeldt, Abhinav P. Acharya   +28 more
wiley   +1 more source

Partial Immunoblotting of 2D-Gels: A Novel Method to Identify Post-Translationally Modified Proteins Exemplified for the Myelin Acetylome

Proteomes, 2017
Post-translational modifications (PTMs) play a key role in regulating protein function, yet their identification is technically demanding. Here, we present a straightforward workflow to systematically identify post-translationally modified proteins based
Kathrin Kusch, Marina Uecker, Thomas Liepold, Wiebke Möbius, Christian Hoffmann, Heinz Neumann, Hauke B. Werner, Olaf Jahn   +7 more
doaj   +1 more source

Mapping Human Cortical Areas In Vivo Based on Myelin Content as Revealed by T1- and T2-Weighted MRI

Journal of Neuroscience, 2011
Noninvasively mapping the layout of cortical areas in humans is a continuing challenge for neuroscience. We present a new method of mapping cortical areas based on myelin content as revealed by T1-weighted (T1w) and T2-weighted (T2w) MRI.
M. Glasser, D. V. Van Essen
semanticscholar   +1 more source

Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long‐Gap Peripheral Nerve Injury

Advanced Healthcare Materials, EarlyView.
A decellularized nerve graft (DNG) is modified to generate a porous DNG (PDNG). The PDNG is used to repair a 30‐mm peripheral nerve injury (PNI) defect, and is compared with isograft, serving as the standard, and DNG, a widely used alternative. The result shows that PDNG facilitated nerve regeneration in long‐gap PNI, evidenced by better‐aligned axonal
Olawale Alimi Alimi, Mitchell Kuss, Wen Xue, Bo Liu, Mena Asha Krishnan, Tianshu Pan, Zhi He, Han‐Jun Wang, Yuguo Lei, Kai Yang, Bin Duan   +10 more
wiley   +1 more source

Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex. [PDF]

, 2018
Numerous types of inhibitory neurons sculpt the performance of human neocortical circuits, with each type exhibiting a constellation of subcellular phenotypic features in support of its specialized functions.
Chang, Edward F, Cobbs, Charles, Lein, Ed, Madison, Daniel V, Micheva, Kristina D, Nana, Alissa L, Seeley, William W, Smith, Stephen J, Ting, Jonathan T, Weinberg, Richard J   +9 more
core   +1 more source

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source

Coiling Instability of Multilamellar Membrane Tubes with Anchored Polymers

, 2000
We study experimentally a coiling instability of cylindrical multilamellar stacks of phospholipid membranes, induced by polymers with hydrophobic anchors grafted along their hydrophilic backbone.
A. Goriely, A. Maritan, A. Stasiak, A. Stasiak, C. Hiergeist, Daniel Kandel, E. Evans, H. J. Deuling, H. Ringsdorf, I. Klapper, I. Sakurai, I. Sakurai, Ilan Tsafrir, Joel Stavans, K. Mishima, K.-C. Lin, L. Miao, M. Buchanan, M. Buchanan, Marie-Alice Guedeau-Boudeville, N. H. Tattrie, N. R. Cozzarelli, O. Lehmann, O.-Y. Zhong-can, R. Lipowsky, R. Virchow, V. Frette, W. Helfrich   +27 more
core   +1 more source

Targeted Local Delivery via Fiber‐Embedded Flexible Microchannels Integrated with Film‐Based Implantable Probes

Advanced Materials Technologies, EarlyView.
In this study, a fiber‐embedded drug delivery channel for implantable microprobes, demonstrating the first functional drug delivery system using flexible LCP‐based probes, is developed. The design incorporates fibers for site‐selective drug delivery and electrical functions. The utilization of monolithic thermal bonding simplifies fabrication.
Jaehwan Byun, Jungseub Lee, Hyun Ryul Ryu, Geun Jae Lee, Sung Eun Lee, Sung June Kim, Noo Li Jeon   +6 more
wiley   +1 more source

Coiling Instabilities in Multilamellar Tubes

, 2002
Myelin figures are densely packed stacks of coaxial cylindrical bilayers that are unstable to the formation of coils or double helices. These myelin figures appear to have no intrinsic chirality.
C. D. Santangelo, C.-M. Chen, I. Sakurai, I. Sakurai, I. Tsafrir, I. Tsafrir, J.P. Hurault, K. Lin, K. Mishima, M. Boucif, M. Buchanan, Ou-Yang Zhong-can, P. Nelson, P. Pincus, P.G. de Gennes, R. Bar-Ziv, R. Goldstein, S. Chaieb, V. Frette, W. Helfrich, W. Helfrich   +20 more
core   +1 more source

After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination

Journal of Neuroscience, 2017
There is consensus that, distal to peripheral nerve injury, myelin and Remak cells reorganize to form cellular columns, Bungner's bands, which are indispensable for regeneration.
J. Gómez-Sánchez, Kjara S Pilch, Milou van der Lans, S. Fazal, C. Benito, L. Wagstaff, R. Mirsky, K. Jessen   +7 more
semanticscholar   +1 more source