Results 141 to 150 of about 188,742 (365)

Convolutional Neural Networks for Estimation of Myelin Maturation in Infant Brain [PDF]

open access: yesarXiv, 2019
Myelination plays an important role in the neurological development of infant brain and MRI can visualize the myelination extension as T1 high and T2 low signal intensity at white matter. We tried to construct a convolutional neural network machine learning model to estimate the myelination. Eight layers CNN architecture was constructed to estimate the
arxiv  

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

open access: yesJournal of Experimental Medicine, 2015
Lampron et al. use a cuprizone mouse model of demyelination/remyelination to show that in CX3CR1-deficient mice, the clearance of myelin debris by microglia is impaired, affecting the integrity of axon and myelin sheaths.
Antoine Lampron   +9 more
semanticscholar   +1 more source

Electroactive Electrospun Nanofibrous Scaffolds: Innovative Approaches for Improved Skin Wound Healing

open access: yesAdvanced Science, EarlyView.
This review explores the potential of electroactive electrospun nanofibrous (EEN) scaffolds for enhanced skin wound healing. It discusses how a variety of electroactive materials can be prepared into EEN scaffolds via electrospinning technology, and their applications in various wound types. The review provides insights into the future perspectives for
Yang Zhang   +10 more
wiley   +1 more source

Contrast‐enhanced micro‐computed tomography of compartment and time‐dependent changes in femoral cartilage and subchondral plate in a murine model of osteoarthritis

open access: yesThe Anatomical Record, Volume 306, Issue 1, Page 92-109, January 2023., 2023
Abstract A lack of understanding of the mechanisms underlying osteoarthritis (OA) progression limits the development of effective long‐term treatments. Quantitatively tracking spatiotemporal patterns of cartilage and bone degeneration is critical for assessment of more appropriately targeted OA therapies.
Deva D. Chan   +8 more
wiley   +1 more source

The role of myelin damage in Alzheimer’s disease pathology

open access: yesArchives of medical science : AMS, 2018
Although Alois Alzheimer described myelin disruption in Alzheimer’s disease (AD) as early as in 1911, his observation has escaped the attention of researchers since that time.
E. Papuć, K. Rejdak
semanticscholar   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

open access: yesAdvanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu   +7 more
wiley   +1 more source

Endostructural and periosteal growth of the human humerus

open access: yesThe Anatomical Record, Volume 306, Issue 1, Page 60-78, January 2023., 2023
Abstract The growth and development of long bones are of considerable interests in the fields of comparative anatomy and palaeoanthropology, as evolutionary changes and adaptations to specific physical activity patterns are expected to be revealed during bone ontogeny.
Thomas George O'Mahoney   +3 more
wiley   +1 more source

Periods of synchronized myelin changes shape brain function and plasticity

open access: yesNature Neuroscience, 2021
Omar de Faria   +5 more
semanticscholar   +1 more source

Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2017
Significance Myelin is a potent inhibitor of axon regeneration. In the central nervous system, failure to clear myelin debris after injury presents a major roadblock to recovery.
Amanda Brosius Lutz   +8 more
semanticscholar   +1 more source

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