Results 161 to 170 of about 188,742 (365)

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

open access: yesAdvanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang   +13 more
wiley   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang   +9 more
wiley   +1 more source

Fast, Precise Myelin Water Quantification using DESS MRI and Kernel Learning [PDF]

open access: yesarXiv, 2018
Purpose: To investigate the feasibility of myelin water content quantification using fast dual-echo steady-state (DESS) scans and machine learning with kernels. Methods: We optimized combinations of steady-state (SS) scans for precisely estimating the fast-relaxing signal fraction ff of a two-compartment signal model, subject to a scan time ...
arxiv  

Preservation of a remote fear memory requires new myelin formation

open access: yesNature Neuroscience, 2020
Simon Pan   +4 more
semanticscholar   +1 more source

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

open access: yesAggregate, EarlyView.
Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang   +3 more
wiley   +1 more source

Central and peripheral dysmyelination in a 3‐year‐old girl with ring chromosome 18

open access: yesClinical Case Reports, 2019
Myelin basic protein (MBP) contributes to peripheral and central nervous system myelin. Developmental myelinopathies exist on a clinical spectrum, but MBP is not included on leukodystrophy or CMT gene panels.
Dawn Brianna Lammert   +6 more
doaj   +1 more source

Work Stressors and Asthma in Female and Male US Workers: Findings From the National Health Interview Survey

open access: yesAmerican Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Prior work has linked work stressors to asthma. However, research related to gender‐specific associations remains sparse and yielded mixed results. We aimed to address this gap. Methods We drew on cross‐sectional data from the 2015 National Health Interview Survey (individual‐level response rate = 79.7%).
Adrian Loerbroks   +5 more
wiley   +1 more source

Myelin figures from microbial glycolipid biosurfactant amphiphiles [PDF]

open access: yesarXiv
Myelin figures (MFs) -- cylindrical lyotropic liquid crystalline structures consisting of concentric arrays of bilayers and aqueous media -- arise from the hydration of the bulk lamellar phase of many common amphiphiles. Prior efforts have concentrated on the formation, structure, and dynamics of myelin produced by phosphatidylcholine (PC)-based ...
arxiv  

The modelling of the action potentials in myelinated nerve fibres [PDF]

open access: yesarXiv
The classical Hodgkin-Huxley model describes the propagation of an axon potential (AP) in unmyelinated axons. In many cases the axons have a myelin sheath and the experimental studies have then revealed significant changes in the velocity of APs. In this paper, a theoretical model is proposed describing the AP propagation in myelinated axons. As far as
arxiv  

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