Results 61 to 70 of about 188,742 (365)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Anticipatory banking of samples enables diagnosis of adenylosuccinase deficiency following molecular autopsy in an infant with vacuolating leukoencephalopathy

American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 234-237, January 2023., 2023
Abstract Adenylosuccinase deficiency is a rare inborn error of metabolism. We present a newborn who died at 52 days of age with clinical features suggestive of severe epileptic encephalopathy and leukodystrophy of unknown cause. Post‐mortem examination showed an unusual vacuolar appearance of the brain.
Spatikha Sitaram, Hetalika C. Banka, Grace Vassallo, Julija Pavaine, Adele Fairclough, Ronnie Wright, Lynette Fairbanks, Jörgen Bierau, Lydia Bowden, Bernd Schwahn, Alistair Horman, Siddharth Banka   +11 more
wiley   +1 more source

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

eLife, 2019
Myelin serves as an axonal insulator that facilitates rapid nerve conduction along axons. By transmission electron microscopy, a healthy myelin sheath comprises compacted membrane layers spiraling around the cross-sectioned axon. Previously we identified
Michelle S Erwig, Julia Patzig, Anna M Steyer, Payam Dibaj, Mareike Heilmann, Ingo Heilmann, Ramona B Jung, Kathrin Kusch, Wiebke Möbius, Olaf Jahn, Klaus-Armin Nave, Hauke B Werner   +11 more
doaj   +1 more source

Paranodal Axoglial Junctions, an Essential Component in Axonal Homeostasis

Frontiers in Cell and Developmental Biology, 2022
In vertebrates, a high density of voltage-gated Na+ channel at nodes of Ranvier and of voltage-gated K+ channel at juxtaparanodes is necessary for rapid propagation of action potential, that is, for saltatory conduction in myelinated axons.
Tomoko Ishibashi, Hiroko Baba
doaj   +1 more source

Bone‐wise rigid registration of femur, tibia, and fibula for the tracking of temporal changes

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Multiple myeloma (MM) induces temporal alterations in bone structure, such as osteolytic bone lesions, which are challenging to identify through manual image interpretation. The large variation in radiologists' assessments, even at expert centers, further complicates diagnosis.
Arttu Ruohola, Ville Haapamäki, Eero Salli, Tuomas Kaseva, Marko Kangasniemi, Sauli Savolainen   +5 more
wiley   +1 more source

Emerging cellular themes in leukodystrophies

Frontiers in Cell and Developmental Biology, 2022
Leukodystrophies are a broad spectrum of neurological disorders that are characterized primarily by deficiencies in myelin formation. Clinical manifestations of leukodystrophies usually appear during childhood and common symptoms include lack of motor ...
Joseph C. Nowacki, Ashley M. Fields, Meng Meng Fu   +2 more
doaj   +1 more source

Changes of statistical structural fluctuations unveils an early compacted degraded stage of PNS myelin [PDF]

Scientific Reports 4, 5430 (2014), 2013
Degradation of the myelin sheath is a common pathology underlying demyelinating neurological diseases from Multiple Sclerosis to Leukodistrophies. Although large malformations of myelin ultrastructure in the advanced stages of Wallerian degradation is known, its subtle structural variations at early stages of demyelination remains poorly characterized.
arxiv   +1 more source

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
wiley   +1 more source

Inflammation, Cognition, and White Matter in Older Adults: An Examination by Race

Frontiers in Aging Neuroscience, 2020
ObjectivesNon-Latino Black adults have greater risk for Alzheimer’s dementia compared to non-Latino White adults, possibly due to factors disproportionally affecting Black adults including cardiovascular disease (CVD).
Elizabeth A. Boots, Elizabeth A. Boots, Karla J. Castellanos, Liang Zhan, Lisa L. Barnes, Lisa L. Barnes, Lisa Tussing-Humphreys, Lisa Tussing-Humphreys, Lisa Tussing-Humphreys, Sean C. L. Deoni, Melissa Lamar, Melissa Lamar, Melissa Lamar   +12 more
doaj   +1 more source

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

Acta Neuropathologica, 2019
Microglia are highly plastic immune cells which exist in a continuum of activation states. By shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which differentiate to myelin-forming cells, microglia participate in both ...
Marta Lombardi, Roberta Parolisi, Federica Scaroni, E. Bonfanti, A. Gualerzi, M. Gabrielli, N. Kerlero de Rosbo, A. Uccelli, P. Giussani, P. Viani, C. Garlanda, M. Abbracchio, L. Chaabane, A. Buffo, M. Fumagalli, C. Verderio   +15 more
semanticscholar   +1 more source