Background: Myelin basic protein (MBP) synthesis and Fyn kinase activity are important for CNS myelination. Results: Oligodendroglial hnRNP F is associated with RNA granules, a target of Fyn, and modulates MBP translation.
Robin White+5 more
semanticscholar +1 more source
Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder. [PDF]
Recent findings suggest the formation of myelin in the central nervous system by oligodendrocytes is a continuous process that can be modified with experience.
Chao, Linda L+4 more
core +1 more source
Structural and molecular characteristics of axons in the long head of the biceps tendon [PDF]
The innervation of the long head of the biceps tendon (LHBT) is not sufficiently documented. This is a drawback since pathologies of the LHBT are a major source of shoulder pain.
Blumer, Roland+7 more
core +1 more source
Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone. [PDF]
Using a family of synthetic tetradecamer oligonucleotides as a primer for cDNA synthesis and a second family of tetradecamers as a hybridization probe, we have prepared and isolated a cDNA clone of mouse myelin basic protein (MBP). The clone, pNZ111, corresponds to the region of the mRNA that codes for an amino acid sequence present in all four major ...
Anthony T. Campagnoni+4 more
openaire +3 more sources
Effect of Sox10 on remyelination of the hippocampus in cuprizone‐induced demyelinated mice
Objective The low number of oligodendrocytes (OLs) in the hippocampus of patients with schizophrenia suggests that hippocampal demyelination is changed in this condition. Sox10 is expressed throughout OL development.
Yu Shao+7 more
doaj +1 more source
Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain. [PDF]
BackgroundIschemia, white matter injury, and Alzheimer's disease (AD) pathologies often co-exist in aging brain. How one condition predisposes to, interacts with, or perhaps causes the others remains unclear.ObjectivesTo better understand the link ...
Ander, Bradley P+7 more
core
Nanoscale correlated disorder in out-of-equilibrium myelin ultrastructure
Ultrastructural fluctuations at nanoscale are fundamental to assess properties and functionalities of advanced out-of-equilibrium materials. We have taken myelin as a model of supramolecular assembly in out-of-equilibrium living matter.
Bianconi, Antonio+6 more
core +1 more source
The lateral membrane organization and dynamics of myelin proteins PLP and MBP are dictated by distinct galactolipids and the extracellular matrix. [PDF]
In the central nervous system, lipid-protein interactions are pivotal for myelin maintenance, as these interactions regulate protein transport to the myelin membrane as well as the molecular organization within the sheath. To improve our understanding of
Hande Ozgen+7 more
doaj +1 more source
Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice
The aggregation of abnormally phosphorylated tau protein in neurons and glia is a neuropathological hallmark of several neurodegenerative disorders, collectively known as tauopathies.
Justyna Zareba-Paslawska+4 more
doaj +1 more source
Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination [PDF]
Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage.
Bramlett+38 more
core +1 more source