Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients [PDF]
, 2016 Purpose: Methotrexate administration is associated with frequent adverse neurological events during treatment for childhood acute lymphoblastic leukemia.
Baird, Susan F. +5 more
core +2 more sources
Early myelin breakdown following sural nerve crush: a freeze-fracture study
Brazilian Journal of Medical and Biological Research, 2000 In this study we describe the early changes of the myelin sheath following surgical nerve crush. We used the freeze-fracture technique to better evaluate myelin alterations during an early stage of Wallerian degeneration.
A.M.B. Martinez, S. Canavarro
doaj +1 more source
Inside-out and standard vein grafts associated with platelet-rich plasma (PRP) in sciatic nerve repair. A histomorphometric study [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To evaluated the tubulization technique with standard and inside-out vein, filled or not with platelet-rich plasma (PRP), in sciatic nerve repair.
José Sidney Roque +9 more
doaj +1 more source
Transplantation of Ciliary Neurotrophic Factor-Expressing Adult Oligodendrocyte Precursor Cells Promotes Remyelination and Functional Recovery after SpinalCord Injury [PDF]
, 2010 Demyelination contributes to the dysfunction after traumatic spinal cord injury (SCI). We explored whether the combination of neurotrophic factors and transplantation of adult rat spinal cord oligodendrocyte precursor cells (OPCs) could enhance ...
Cao, Qilin +11 more
core +1 more source
Frontiers in Psychiatry, 2018 White matter and myelin sheath integrity are disrupted in schizophrenia, and non-invasive magnetic brain stimulation targeting these tracts is a promising new therapeutic approach.
Zuoli Sun +6 more
doaj +1 more source
The polarity protein Scribble regulates myelination and remyelination in the central nervous system.
PLoS Biology, 2015 The development and regeneration of myelin by oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), requires profound changes in cell shape that lead to myelin sheath initiation and formation.
Andrew A Jarjour +7 more
doaj +1 more source
Heterogeneity and regulation of oligodendrocyte morphology
Frontiers in Cell and Developmental Biology, 2022 Oligodendrocytes form multiple myelin sheaths in the central nervous system (CNS), which increase nerve conduction velocity and are necessary for basic and higher brain functions such as sensory function, motor control, and learning.
Yasuyuki Osanai +6 more
doaj +1 more source
Correlated disorder in myelinated axons orientational geometry and structure
, 2017 While the ultrastructure of the myelin has been considered to be a quasi-crystalline stable system, nowadays its multiscale complex dynamics appears to play a key role for its functionality, degeneration and repair processes following neurological ...
Bianconi, Antonio +3 more
core +1 more source
Extent and mechanism of sealing in transected giant axons of squid and earthworms [PDF]
, 1994 Transected axons are often assumed to seal at their cut ends by the formation of continuous membrane barriers that allow for the restoration of function in the axonal stumps.
Ballinger, Martis L. +3 more
core +1 more source
Advanced Functional Materials, EarlyView.This study introduces a conductive nerve guidance conduit integrated with wireless electrical stimulation through alternating magnetic fields, which induces currents and creates a supportive microenvironment for nerve regeneration. In vivo studies show that this approach significantly enhanced myelin restoration, gastrocnemius muscle regeneration ...
Shiheng Liu +7 more
wiley +1 more source