Aerobic exercise attenuates abnormal myelination and oligodendrocyte differentiation in 3xTg-AD mice
Experimental Gerontology, 2023 Pathological features of Alzheimer's Disease (AD) include alterations in the structure and function of neurons as well as of myelin sheaths. Accumulated evidence shows that aerobic type of exercise can enhance neuroplasticity in mouse models of AD ...
Dan Qiu +4 more
doaj
eLife, 2023 Oligodendrocytes in the central nervous system exhibit significant variability in the number of myelin sheaths that are supported by each cell, ranging from 1 to 50 (1-8). Myelin production during development is dynamic and involves both sheath formation
Adam R Almeida, Wendy B Macklin
doaj +1 more source
Clemastine improves optic nerve myelin sheath regeneration and visual function in aged mice
陆军军医大学学报, 2022 Objective To investigate the changes in myelin sheath of optic nerve in mice during the process of aging and explore the effect of clemastine, a pro-myelination drug, on visual function of aging mice.
RAN Qi, CHEN Lin, YE Jian
doaj +1 more source
gACSON software for automated segmentation and morphology analyses of myelinated axons in 3D electron microscopy [PDF]
arXiv, 2021 Background and Objective: Advances in electron microscopy (EM) now allow three-dimensional (3D) imaging of hundreds of micrometers of tissue with nanometer-scale resolution, providing new opportunities to study the ultrastructure of the brain. In this work, we introduce a freely available Matlab-based gACSON software for visualization, segmentation ...
arxiv
Effects of nerve bundle geometry on neurotrauma evaluation [PDF]
International Journal for Numerical Methods in Biomedical
Engineering, 34 (2018) e3118, 2020 Objective: We confirm that alteration of a neuron structure can induce abnormalities in signal propagation for nervous systems, as observed in brain damage. Here, we investigate the effects of geometrical changes and damage of a neuron structure in 2 scaled nerve bundle models, made of myelinated nerve fibers or unmyelinated nerve fibers. Methods: We
arxiv +1 more source
Are there optical communication channels in the brain?
, 2017 Despite great progress in neuroscience, there are still fundamental unanswered questions about the brain, including the origin of subjective experience and consciousness. Some answers might rely on new physical mechanisms. Given that biophotons have been
Barclay, Paul +4 more
core +1 more source
Stereological Methods for Estimating the Myelin Sheaths of the Myelinated Fibers in White Matter [PDF]
The Anatomical Record, 2009 AbstractIn the present study, efficient and unbiased stereological techniques to investigate the myelin sheaths of the myelinated fibers in rat white matter were established. In the present design, four tissue blocks were obtained from the entire white matter of rat brain in a uniform, random fashion.
Li, Chen +6 more
openaire +4 more sources
RP-CARS reveals molecular spatial order anomalies in myelin of an animal model of Krabbe disease [PDF]
Journal of Biophotonics 10 (2017) 385-393, 2020 Krabbe disease (KD) is a rare demyelinating sphingolipidosis, often fatal in the first years of life. It is caused by the inactivation of the galactocerebrosidase (GALC) enzyme that causes an increase in the cellular levels of psychosine considered to be at the origin of the tissue-level effects.
arxiv +1 more source
Early myelin breakdown following sural nerve crush: a freeze-fracture study
Brazilian Journal of Medical and Biological Research, 2000 In this study we describe the early changes of the myelin sheath following surgical nerve crush. We used the freeze-fracture technique to better evaluate myelin alterations during an early stage of Wallerian degeneration.
A.M.B. Martinez, S. Canavarro
doaj +1 more source
Inside-out and standard vein grafts associated with platelet-rich plasma (PRP) in sciatic nerve repair. A histomorphometric study [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To evaluated the tubulization technique with standard and inside-out vein, filled or not with platelet-rich plasma (PRP), in sciatic nerve repair.
José Sidney Roque +9 more
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