Results 61 to 70 of about 53,137 (327)

Ndrg1 in development and maintenance of the myelin sheath

Neurobiology of Disease, 2011
CMT4D disease is a severe autosomal recessive demyelinating neuropathy with extensive axonal loss leading to early disability, caused by mutations in the N-myc downstream regulated gene 1 (NDRG1). NDRG1 is expressed at particularly high levels in the Schwann cell (SC), but its physiological function(s) are unknown.
Toshiyuki Miyata, Kim W. Carter, Dora Angelicheva, Tomohiko Okuda, Michelle Nourallah, Michael Hunter, Julian Blake, Dexing Huang, Trevor J. Kilpatrick, Luba Kalaydjieva, J. R. Muddle, Rosalind H.M. King, David Chandler, Grant Morahan, Sash Lopaticki   +14 more
openaire   +4 more sources

MicroRNA-23a promotes myelination in the central nervous system. [PDF]

, 2013
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment ...
Fu, Ying-Hui, Heng, Mary Y, Huang, Yong, Lin, Shu-Ting, Ptácek, Louis J, Zhang, Luoying   +5 more
core   +2 more sources

Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate

eLife, 2023
Oligodendrocytes in the central nervous system exhibit significant variability in the number of myelin sheaths that are supported by each cell, ranging from 1 to 50 (1-8). Myelin production during development is dynamic and involves both sheath formation
Adam R Almeida, Wendy B Macklin
doaj   +1 more source

Stereological Methods for Estimating the Myelin Sheaths of the Myelinated Fibers in White Matter [PDF]

The Anatomical Record, 2009
AbstractIn the present study, efficient and unbiased stereological techniques to investigate the myelin sheaths of the myelinated fibers in rat white matter were established. In the present design, four tissue blocks were obtained from the entire white matter of rat brain in a uniform, random fashion.
Li, Chen, Yang, Shu, Chen, Lin, Lu, Wei, Tang, Yong, Gundersen, Hans Jørgen Gottlieb, Qiu, Xuan   +6 more
openaire   +4 more sources

Clemastine improves optic nerve myelin sheath regeneration and visual function in aged mice

陆军军医大学学报, 2022
Objective To investigate the changes in myelin sheath of optic nerve in mice during the process of aging and explore the effect of clemastine, a pro-myelination drug, on visual function of aging mice.
RAN Qi, CHEN Lin, YE Jian
doaj   +1 more source

Early myelin breakdown following sural nerve crush: a freeze-fracture study

Brazilian Journal of Medical and Biological Research, 2000
In this study we describe the early changes of the myelin sheath following surgical nerve crush. We used the freeze-fracture technique to better evaluate myelin alterations during an early stage of Wallerian degeneration.
A.M.B. Martinez, S. Canavarro
doaj   +1 more source

Transplantation of Ciliary Neurotrophic Factor-Expressing Adult Oligodendrocyte Precursor Cells Promotes Remyelination and Functional Recovery after SpinalCord Injury [PDF]

, 2010
Demyelination contributes to the dysfunction after traumatic spinal cord injury (SCI). We explored whether the combination of neurotrophic factors and transplantation of adult rat spinal cord oligodendrocyte precursor cells (OPCs) could enhance ...
Cao, Qilin, Cheng, Xiaoxin, DeVries, William H., He, Qian, Howard, Russell M., Kim, Dong H., Magnuson, David S. K., Shields, Christopher B., Wang, Yaping, Whittemore, Scott R., Xu, Xiao-Ming, Zhang, Yiping   +11 more
core   +1 more source

Low Field Magnetic Stimulation Ameliorates Schizophrenia-Like Behavior and Up-Regulates Neuregulin-1 Expression in a Mouse Model of Cuprizone-Induced Demyelination

Frontiers in Psychiatry, 2018
White matter and myelin sheath integrity are disrupted in schizophrenia, and non-invasive magnetic brain stimulation targeting these tracts is a promising new therapeutic approach.
Zuoli Sun, Tianhe Jiang, Yan Wu, Chao Ma, Yi He, Jian Yang, Jian Yang   +6 more
doaj   +1 more source

Inside-out and standard vein grafts associated with platelet-rich plasma (PRP) in sciatic nerve repair. A histomorphometric study [PDF]

Acta Cirúrgica Brasileira, 2017
Purpose: To evaluated the tubulization technique with standard and inside-out vein, filled or not with platelet-rich plasma (PRP), in sciatic nerve repair.
José Sidney Roque, Karina Torres Pomini, Rogério Leone Buchaim, Daniela Vieira Buchaim, Jesus Carlos Andreo, Domingos Donizeti Roque, Antonio de Castro Rodrigues, Geraldo Marco Rosa Júnior, Luis Henrique Rapucci Moraes, Fausto Viterbo   +9 more
doaj   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source