gACSON software for automated segmentation and morphology analyses of myelinated axons in 3D electron microscopy [PDF]
arXiv, 2021 Background and Objective: Advances in electron microscopy (EM) now allow three-dimensional (3D) imaging of hundreds of micrometers of tissue with nanometer-scale resolution, providing new opportunities to study the ultrastructure of the brain. In this work, we introduce a freely available Matlab-based gACSON software for visualization, segmentation ...
arxiv
RP-CARS reveals molecular spatial order anomalies in myelin of an animal model of Krabbe disease [PDF]
Journal of Biophotonics 10 (2017) 385-393, 2020 Krabbe disease (KD) is a rare demyelinating sphingolipidosis, often fatal in the first years of life. It is caused by the inactivation of the galactocerebrosidase (GALC) enzyme that causes an increase in the cellular levels of psychosine considered to be at the origin of the tissue-level effects.
arxiv +1 more source
Stereological Methods for Estimating the Myelin Sheaths of the Myelinated Fibers in White Matter [PDF]
The Anatomical Record, 2009 AbstractIn the present study, efficient and unbiased stereological techniques to investigate the myelin sheaths of the myelinated fibers in rat white matter were established. In the present design, four tissue blocks were obtained from the entire white matter of rat brain in a uniform, random fashion.
Li, Chen +6 more
openaire +4 more sources
Effects of nerve bundle geometry on neurotrauma evaluation [PDF]
International Journal for Numerical Methods in Biomedical
Engineering, 34 (2018) e3118, 2020 Objective: We confirm that alteration of a neuron structure can induce abnormalities in signal propagation for nervous systems, as observed in brain damage. Here, we investigate the effects of geometrical changes and damage of a neuron structure in 2 scaled nerve bundle models, made of myelinated nerve fibers or unmyelinated nerve fibers. Methods: We
arxiv +1 more source
Early myelin breakdown following sural nerve crush: a freeze-fracture study
Brazilian Journal of Medical and Biological Research, 2000 In this study we describe the early changes of the myelin sheath following surgical nerve crush. We used the freeze-fracture technique to better evaluate myelin alterations during an early stage of Wallerian degeneration.
A.M.B. Martinez, S. Canavarro
doaj +1 more source
Inside-out and standard vein grafts associated with platelet-rich plasma (PRP) in sciatic nerve repair. A histomorphometric study [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To evaluated the tubulization technique with standard and inside-out vein, filled or not with platelet-rich plasma (PRP), in sciatic nerve repair.
José Sidney Roque +9 more
doaj +1 more source
Changes of statistical structural fluctuations unveils an early compacted degraded stage of PNS myelin [PDF]
Scientific Reports 4, 5430 (2014), 2013 Degradation of the myelin sheath is a common pathology underlying demyelinating neurological diseases from Multiple Sclerosis to Leukodistrophies. Although large malformations of myelin ultrastructure in the advanced stages of Wallerian degradation is known, its subtle structural variations at early stages of demyelination remains poorly characterized.
arxiv +1 more source
Frontiers in Psychiatry, 2018 White matter and myelin sheath integrity are disrupted in schizophrenia, and non-invasive magnetic brain stimulation targeting these tracts is a promising new therapeutic approach.
Zuoli Sun +6 more
doaj +1 more source
The roles of microglia and astrocytes in myelin phagocytosis in the central nervous system
Journal of Cerebral Blood Flow and Metabolism, 2022 Myelination is an important process in the central nervous system (CNS). Oligodendrocytes (OLs) extend multiple layers to densely sheath on axons, composing the myelin to achieve efficient electrical signal conduction.
Tongtong Xu +7 more
semanticscholar +1 more source
The polarity protein Scribble regulates myelination and remyelination in the central nervous system.
PLoS Biology, 2015 The development and regeneration of myelin by oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), requires profound changes in cell shape that lead to myelin sheath initiation and formation.
Andrew A Jarjour +7 more
doaj +1 more source