Results 61 to 70 of about 48,603 (346)

Changes of statistical structural fluctuations unveils an early compacted degraded stage of PNS myelin [PDF]

Scientific Reports 4, 5430 (2014), 2013
Degradation of the myelin sheath is a common pathology underlying demyelinating neurological diseases from Multiple Sclerosis to Leukodistrophies. Although large malformations of myelin ultrastructure in the advanced stages of Wallerian degradation is known, its subtle structural variations at early stages of demyelination remains poorly characterized.
arxiv   +1 more source

Asymptotic construction of pulses in the Hodgkin Huxley model for myelinated nerves [PDF]

, 2005
A quantitative description of pulses and wave trains in the spatially discrete Hodgkin-Huxley model for myelinated nerves is given. Predictions of the shape and speed of the waves and the thresholds for propagation failure are obtained.
Carpio, A.
core   +3 more sources

Low Field Magnetic Stimulation Ameliorates Schizophrenia-Like Behavior and Up-Regulates Neuregulin-1 Expression in a Mouse Model of Cuprizone-Induced Demyelination

Frontiers in Psychiatry, 2018
White matter and myelin sheath integrity are disrupted in schizophrenia, and non-invasive magnetic brain stimulation targeting these tracts is a promising new therapeutic approach.
Zuoli Sun, Tianhe Jiang, Yan Wu, Chao Ma, Yi He, Jian Yang, Jian Yang   +6 more
doaj   +1 more source

The development of a ε-polycaprolactone (PCL) scaffold for CNS repair [PDF]

, 2012
Potential treatment strategies for the repair of spinal cord injury (SCI) currently favour a combinatorial approach incorporating several factors, including exogenous cell transplantation and biocompatible scaffolds. The use of scaffolds for bridging the
Gelain F., Lampe K.J., Mathis O. Riehle, Nikolaj Gadegaard, Peter S. Donoghue, Rebecca Lamond, Stephanie D. Boomkamp, Susan C. Barnett, Tao Sun, Thouas G.A.   +9 more
core   +1 more source

The polarity protein Scribble regulates myelination and remyelination in the central nervous system.

PLoS Biology, 2015
The development and regeneration of myelin by oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), requires profound changes in cell shape that lead to myelin sheath initiation and formation.
Andrew A Jarjour, Amanda Boyd, Lukas E Dow, Rebecca K Holloway, Sandra Goebbels, Patrick O Humbert, Anna Williams, Charles ffrench-Constant   +7 more
doaj   +1 more source

A physical perspective to understand myelin II: The physical origin of myelin development

Frontiers in Neuroscience, 2022
The physical principle of myelin development is obtained from our previous study by explaining Peter’s quadrant mystery: an externally applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath ...
Yonghong Liu, Wenji Yue, Shoujun Yu, Tian Zhou, Yapeng Zhang, Ran Zhu, Bing Song, Tianruo Guo, Fenglin Liu, Yubin Huang, Tianzhun Wu, Tianzhun Wu, Hao Wang, Hao Wang   +13 more
doaj   +1 more source

Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). The disease hallmarks cortical lesion, central vein sign (CVS) and paramagnetic rim lesions identified in MS have not yet been comprehensively investigated in ...
Lei Su, Joseph Kuchling, Chenyang Gao, Thoralf Niendorf, Carsten Finke, Zhe Zhang, Ai Guo, Jing Jing, De‐Cai Tian, Yu‐Jing Li, Mengting Zhang, Xiaoyu Shi, Xinyao Liu, Huabing Wang, Yaou Liu, Claudia Chien, Michael Levy, Yunyun Duan, Friedemann Paul, Fu‐Dong Shi   +19 more
wiley   +1 more source

Heterogeneity and regulation of oligodendrocyte morphology

Frontiers in Cell and Developmental Biology, 2022
Oligodendrocytes form multiple myelin sheaths in the central nervous system (CNS), which increase nerve conduction velocity and are necessary for basic and higher brain functions such as sensory function, motor control, and learning.
Yasuyuki Osanai, Yasuyuki Osanai, Reiji Yamazaki, Yoshiaki Shinohara, Yoshiaki Shinohara, Nobuhiko Ohno, Nobuhiko Ohno   +6 more
doaj   +1 more source

Magnetic Field‐Assisted Conductive Nerve Guidance Conduit Enabling Peripheral Nerve Regeneration with Wireless Electrical Stimulation

Advanced Functional Materials, EarlyView.
This study introduces a conductive nerve guidance conduit integrated with wireless electrical stimulation through alternating magnetic fields, which induces currents and creates a supportive microenvironment for nerve regeneration. In vivo studies show that this approach significantly enhanced myelin restoration, gastrocnemius muscle regeneration ...
Shiheng Liu, Li‐Fang Zhu, Ming‐Wei Chang, Chao Li, Tingyu Wang, Rong Wang, Xinghao Yan, Baolin Wang   +7 more
wiley   +1 more source

Myelin histology: a key tool in nervous system research

Neural Regeneration Research
The myelin sheath is a lipoprotein-rich, multilayered structure capable of increasing conduction velocity in central and peripheral myelinated nerve fibers. Due to the complex structure and composition of myelin, various histological techniques have been
Óscar Darío García-García, Víctor Carriel, Jesús Chato-Astrain   +2 more
doaj   +1 more source