The polarity protein Scribble regulates myelination and remyelination in the central nervous system.
PLoS Biology, 2015 The development and regeneration of myelin by oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), requires profound changes in cell shape that lead to myelin sheath initiation and formation.
Andrew A Jarjour +7 more
doaj +1 more source
Correlated disorder in myelinated axons orientational geometry and structure
, 2017 While the ultrastructure of the myelin has been considered to be a quasi-crystalline stable system, nowadays its multiscale complex dynamics appears to play a key role for its functionality, degeneration and repair processes following neurological ...
Bianconi, Antonio +3 more
core +1 more source
Probing white-matter microstructure with higher-order diffusion tensors and susceptibility tensor MRI. [PDF]
, 2013 Diffusion MRI has become an invaluable tool for studying white matter microstructure and brain connectivity. The emergence of quantitative susceptibility mapping and susceptibility tensor imaging (STI) has provided another unique tool for assessing the ...
Li, Wei, Liu, Chunlei, Murphy, Nicole E
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Heterogeneity and regulation of oligodendrocyte morphology
Frontiers in Cell and Developmental Biology, 2022 Oligodendrocytes form multiple myelin sheaths in the central nervous system (CNS), which increase nerve conduction velocity and are necessary for basic and higher brain functions such as sensory function, motor control, and learning.
Yasuyuki Osanai +6 more
doaj +1 more source
Monoclonal antibodies to the cells of a regenerating limb [PDF]
, 1985 Monoclonal antibodies were raised against differentiated cells, and blastemal cells from regenerating limbs of adult newts (Notophthalmus viridescens) and screened for specific staining by immunocytochemistry.
Brockes, Jeremy P., Kintner, Chris R.
core
Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan +12 more
wiley +1 more source
Myelin histology: a key tool in nervous system research
Neural Regeneration ResearchThe myelin sheath is a lipoprotein-rich, multilayered structure capable of increasing conduction velocity in central and peripheral myelinated nerve fibers. Due to the complex structure and composition of myelin, various histological techniques have been
Óscar Darío García-García +2 more
doaj +1 more source
Salvianolic acid B protects the myelin sheath around injured spinal cord axons
Neural Regeneration Research, 2016 Salvianolic acid B, an active pharmaceutical compound present in Salvia miltiorrhiza, exerts a neuroprotective effect in animal models of brain and spinal cord injury.
Zhe Zhu +4 more
doaj +1 more source
A physical perspective to understand myelin II: The physical origin of myelin development
Frontiers in Neuroscience, 2022 The physical principle of myelin development is obtained from our previous study by explaining Peter’s quadrant mystery: an externally applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath ...
Yonghong Liu +13 more
doaj +1 more source
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients [PDF]
, 2016 Purpose: Methotrexate administration is associated with frequent adverse neurological events during treatment for childhood acute lymphoblastic leukemia.
Baird, Susan F. +5 more
core +2 more sources