Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice
Journal of Lipid Research, 2022 The myelin sheath, which is wrapped around axons, is a lipid-enriched structure produced by mature oligodendrocytes. Disruption of the myelin sheath is observed in several neurological diseases, such as multiple sclerosis.
Yiran Liu +14 more
doaj
Salvianolic acid B protects the myelin sheath around injured spinal cord axons
Neural Regeneration Research, 2016 Salvianolic acid B, an active pharmaceutical compound present in Salvia miltiorrhiza, exerts a neuroprotective effect in animal models of brain and spinal cord injury.
Zhe Zhu +4 more
doaj +1 more source
A physical perspective to understand myelin. II. The physical origin of myelin development [PDF]
arXiv, 2021 The physical principle of myelin development is obtained from our previous study by explaining Peter's quadrant mystery: an external applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath, respectively. In this study, this principle is considered as a fundamental hypothesis, named Hypothesis-E,
arxiv
Mechanisms for the maintenance and eventual degradation of neurofilament proteins in the distal segments of severed goldfish Mauthner axons [PDF]
, 1996 Cellular mechanisms that might affect the degradation of neurofilament proteins (NFPs) were examined in the distal segments of severed goldfish Mauthner axons (M-axons), which do not degenerate for more than 2 months after severance.
Archer, Cullen +3 more
core +1 more source
Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders
Advanced Functional Materials, EarlyView.This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao +5 more
wiley +1 more source
Engineering the Future of Restorative Clinical Peripheral Nerve Surgery
Advanced Healthcare Materials, EarlyView.What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell +5 more
wiley +1 more source
Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.
PLoS Genetics, 2016 Schwann cells in the peripheral nervous systems extend their membranes to wrap axons concentrically and form the insulating sheath, called myelin. The spaces between layers of myelin are sealed by myelin junctions.
Bo Hu +10 more
doaj +1 more source
Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG. [PDF]
PLoS ONE, 2011 The velocity of the nerve impulse conduction of vertebrates relies on the myelin sheath, an electrically insulating layer that surrounds axons in both the central and peripheral nervous systems, enabling saltatory conduction of the action potential ...
Raquel Bello-Morales +6 more
doaj +1 more source
A physical perspective to understand myelin. I. A physical answer to Peter’s quadrant mystery
Frontiers in Neuroscience, 2022 In the development of oligodendrocytes in the central nervous systems, the inner and outer tongue of the myelin sheath tend to be located within the same quadrant, which was named as Peters quadrant mystery.
Yonghong Liu +13 more
doaj +1 more source
AxonCallosumEM Dataset: Axon Semantic Segmentation of Whole Corpus Callosum cross section from EM Images [PDF]
arXiv, 2023 The electron microscope (EM) remains the predominant technique for elucidating intricate details of the animal nervous system at the nanometer scale. However, accurately reconstructing the complex morphology of axons and myelin sheaths poses a significant challenge.
arxiv