Results 71 to 80 of about 201,896 (346)

Heterogeneity and regulation of oligodendrocyte morphology

Frontiers in Cell and Developmental Biology, 2022
Oligodendrocytes form multiple myelin sheaths in the central nervous system (CNS), which increase nerve conduction velocity and are necessary for basic and higher brain functions such as sensory function, motor control, and learning.
Yasuyuki Osanai, Yasuyuki Osanai, Reiji Yamazaki, Yoshiaki Shinohara, Yoshiaki Shinohara, Nobuhiko Ohno, Nobuhiko Ohno   +6 more
doaj   +1 more source

Magnetic Field‐Assisted Conductive Nerve Guidance Conduit Enabling Peripheral Nerve Regeneration with Wireless Electrical Stimulation

Advanced Functional Materials, EarlyView.
This study introduces a conductive nerve guidance conduit integrated with wireless electrical stimulation through alternating magnetic fields, which induces currents and creates a supportive microenvironment for nerve regeneration. In vivo studies show that this approach significantly enhanced myelin restoration, gastrocnemius muscle regeneration ...
Shiheng Liu, Li‐Fang Zhu, Ming‐Wei Chang, Chao Li, Tingyu Wang, Rong Wang, Xinghao Yan, Baolin Wang   +7 more
wiley   +1 more source

Neurodegeneration in multiple sclerosis

WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
Chronic demyelination results in impaired axon metabolism and function, ultimately leading to progressive neurological decline. Neuroprotective strategies aim to protect axons from inflammatory‐mediated destruction, thereby improving axonal integrity and clinical disability (Image created in BioRender.com).
Gabrielle M. Mey, Kedar R. Mahajan, Tara M. DeSilva   +2 more
wiley   +1 more source

A physical perspective to understand myelin II: The physical origin of myelin development

Frontiers in Neuroscience, 2022
The physical principle of myelin development is obtained from our previous study by explaining Peter’s quadrant mystery: an externally applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath ...
Yonghong Liu, Wenji Yue, Shoujun Yu, Tian Zhou, Yapeng Zhang, Ran Zhu, Bing Song, Tianruo Guo, Fenglin Liu, Yubin Huang, Tianzhun Wu, Tianzhun Wu, Hao Wang, Hao Wang   +13 more
doaj   +1 more source

A physical perspective to understand myelin. II. The physical origin of myelin development [PDF]

arXiv, 2021
The physical principle of myelin development is obtained from our previous study by explaining Peter's quadrant mystery: an external applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath, respectively. In this study, this principle is considered as a fundamental hypothesis, named Hypothesis-E,
arxiv  

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Myelin histology: a key tool in nervous system research

Neural Regeneration Research
The myelin sheath is a lipoprotein-rich, multilayered structure capable of increasing conduction velocity in central and peripheral myelinated nerve fibers. Due to the complex structure and composition of myelin, various histological techniques have been
Óscar Darío García-García, Víctor Carriel, Jesús Chato-Astrain   +2 more
doaj   +1 more source

Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice

Journal of Lipid Research, 2022
The myelin sheath, which is wrapped around axons, is a lipid-enriched structure produced by mature oligodendrocytes. Disruption of the myelin sheath is observed in several neurological diseases, such as multiple sclerosis.
Yiran Liu, David Castano, Francesco Girolamo, Laia Trigueros-Motos, Han-Gyu Bae, Suat Peng Neo, Jeongah Oh, Pradeep Narayanaswamy, Federico Torta, Kerry Anne Rye, Dong-Gyu Jo, Jayantha Gunaratne, Sangyong Jung, Daniela Virgintino, Roshni R. Singaraja   +14 more
doaj  

Salvianolic acid B protects the myelin sheath around injured spinal cord axons

Neural Regeneration Research, 2016
Salvianolic acid B, an active pharmaceutical compound present in Salvia miltiorrhiza, exerts a neuroprotective effect in animal models of brain and spinal cord injury.
Zhe Zhu, Lu Ding, Wen-feng Qiu, Hong-fu Wu, Rui Li   +4 more
doaj   +1 more source

Insights on Advances in 3D Bioprinting for Peripheral Nerve Regeneration

Advanced Therapeutics, EarlyView.
Peripheral nerve injury is a common condition due to trauma that significantly impacts the life of the affected individual. This review explores the anatomy, classification, and pathophysiology of peripheral nerve injuries. It also discusses various types of nerve conduits and presents a detailed review of 3D bioprinted nerve conduits used in both in ...
Nasera Rizwana, Samartha M C, Ashwath Acharya, Goutam Thakur, Manasa Nune, Vipul Agarwal   +5 more
wiley   +1 more source