Results 131 to 140 of about 43,839 (265)

Dynamic induction of the myelin‐associated growth inhibitor Nogo‐A in perilesional plasticity regions after human spinal cord injury

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
Nogo‐A oligodendrocytes expression emerges at perilesional regions over time and suggests an extended therapeutical window for anti‐Nogo‐A pathway trageting interventrions beyond four weeks in patients after spinal cord injury. Abstract The myelin‐associated inhibitor Nogo‐A (Reticulon 4, RTN4) restricts axonal outgrowth, plasticity, and neural ...
Carmen Schwaiger, Thomas Haider, Verena Endmayr, Tobias Zrzavy, Victoria E. Gruber, Gerda Ricken, Anika Simonovska, Simon Hametner, Jan M. Schwab, Romana Höftberger   +9 more
wiley   +1 more source

The modelling of the action potentials in myelinated nerve fibres [PDF]

arXiv
The classical Hodgkin-Huxley model describes the propagation of an axon potential (AP) in unmyelinated axons. In many cases the axons have a myelin sheath and the experimental studies have then revealed significant changes in the velocity of APs. In this paper, a theoretical model is proposed describing the AP propagation in myelinated axons. As far as
arxiv  

Actin Plays a Role in Both Changes in Cell Shape and Gene- Expression Associated with Schwann Cell Myelination [PDF]

, 1997
Cristina Fernández‐Valle, Douglas Gorman, Anna M. Gomez, M. B. Bunge   +3 more
openalex   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Studies on cultured Schwann cells: the induction of myelin synthesis, and the control of their proliferation by a new growth factor [PDF]

, 1981
We have recently described the use of immunological methods to identify and purify rat Schwann cells. In dissociated cultures of neonatal sciatic nerve, all of the cells can be identified by antigenic criteria as either Schwann cells or fibroblasts.
Brockes, J. P., Fryxell, K. J., Lemke, G. E.   +2 more
core  

Dual‐Responsive Multi‐Functional Silica Nanoparticles With Repaired Mitochondrial Functions for Efficient Alleviation of Spinal Cord Injury

Exploration, EarlyView.
Targeting mitochondrial dysfunction presents a potential therapeutic approach for treating spinal cord injury. We have successfully designed and synthesized a functional Se@NADH nanodrug system. This system offers neuroprotective and neuroregenerative benefits by modulating mitochondrial function and neutralizing reactive oxygen species, thereby ...
Guibin Gao, Juanjuan Li, Yanming Ma, Min Xie, Jianxian Luo, Ke Wang, Cheng Peng, Hua Yang, Tianjun Chen, Guowei Zhang, Jiang Ouyang, Hongsheng Lin, Zhisheng Ji   +12 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during Myelination [PDF]

, 2000
Jose C. Rios, Carmen V. Melendez‐Vasquez, Steven Einheber, Marc Lustig, Martin Grumet, John J. Hemperly, Elior Peles, James L. Salzer   +7 more
openalex   +1 more source

Negative regulation of central nervous system myelination by polysialylated-neural cell adhesion molecule [PDF]

, 2000
Perrine Charles, M. P. Hernandez, Bruno Stankoff, Marie‐Stéphane Aigrot, Catherine Colin, Geneviève Rougon, Bernard Zalc, Catherine Lubetzki   +7 more
openalex   +1 more source

Axonal Regulation of Schwann Cell Proliferation and Survival and the Initial Events of Myelination Requires PI 3-Kinase Activity [PDF]

, 2000
Patrice Maurel, James L. Salzer
openalex   +1 more source