Aptamer-based multiplexed proteomic technology for biomarker discovery [PDF]
, 2010 Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands
A Keller +115 more
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Genome-wide DNA methylation assay reveals novel candidate biomarker genes in cervical cancer [PDF]
, 2013 The oncogenic human papilloma viruses (HPVs) are associated with precancerous cervical lesions and development of cervical cancer. The DNA methylation signatures of host genome in normal, precancerous and cervical cancer tissue may indicate tissue ...
Farkas, Sanja A. +3 more
core +1 more source
Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform [PDF]
, 2020 Background: Interleukin 6 concentration is associated with myocardial injury, heart failure, and mortality after myocardial infarction. In the Norwegian tocilizumab non-ST-segment-elevation myocardial infarction trial, the first randomized trial of ...
Aukrust, Pål +12 more
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From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity [PDF]
, 2018 Autoantibodies (AAbs) against von Willebrand factor (vWF)-cleaving protease ADAMTS13 causally relate to thrombotic thrombocytopenic purpura (TTP). How anti-ADAMTS13 AAbs are generated is unknown.
Kanduc Darja
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Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: A hypothesis [PDF]
, 2012 Despite extensive understanding of sleep regulation, the molecular-level cause and function of sleep are unknown. I suggest that they originate in individual neurons and stem from increased production of protein fragments during wakefulness.
Varshavsky, Alexander
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Regulationsmechanismen des Interferon regulatorischen Faktors IRF-4 in der chronisch myeloischen Leukämie [PDF]
, 2005 Zahlreiche Untersuchungen weisen darauf hin, dass die Gruppe der Interferon-regulatorischen Faktoren (IRF), darunter insbesondere ICSBP und IRF-4, in der Pathogenese der CML eine wichtige Rolle spielt.
Neubauer, Andreas (Prof. Dr.) +1 more
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Analysis of VEGF-responsive Genes Involved in the activation of endothelial cells [PDF]
, 2003 BACKGROUND: Identification of the genes and pathways associated with the activation of endothelial cells (ECs) could help uncover the role of ECs in wound healing, vascular permeability, blood brain barrier function, angiogenesis, diabetic retinopathy ...
Geeta D Thakker +4 more
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Plasma Protein Profiling Analysis in Patients with Atrial Fibrillation Before and After Three Different Ablation Techniques [PDF]
, 2023 Background: There are controversies on the pathophysiological alteration in patients with atrial fibrillation (AF) undergoing pulmonary vein isolation using different energy sources.
Bao, Yangyang +22 more
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Different Faces for Different Places: Heterogeneity of Neutrophil Phenotype and Function
Journal of Immunology Research, Volume 2019, Issue 1, 2019., 2019 As the most abundant leukocytes in the circulation, neutrophils are committed to innate and adaptive immune effector function to protect the human body. They are capable of killing intruding microbes through various ways including phagocytosis, release of granules, and formation of extracellular traps.
Peiqing Yang +4 more
wiley +1 more source
Characterization of Cystatin B Interactome in Saliva from Healthy Elderly and Alzheimer's Disease Patients [PDF]
, 2023 Cystatin B is a small, multifunctional protein involved in the regulation of inflammation, innate immune response, and neuronal protection and found highly abundant in the brains of patients with Alzheimer's disease (AD). Recently, our study demonstrated
Bizzarro, Alessandra +12 more
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