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Advanced Science, EarlyView.SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han +8 more
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Myeloid-Derived Suppressor Cells and Radiotherapy
Cancer Immunology Research, 2022Abstract Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of pathologically activated, mostly immature, myeloid cells that exert robust immunosuppressive functions. MDSCs expand during oncogenesis and have been linked to accelerated disease progression and resistance to treatment in both preclinical tumor models ...
Carlos Jiménez-Cortegana +4 more
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Myeloid-derived suppressor cells in glioma
Expert Review of Neurotherapeutics, 2013Glioblastoma is the most prevalent form of gliomas with high aggressive nature and high recurrence. Despite aggressive therapy, including surgery, chemotherapy and radiotherapy, median patient survival is only about 15 months. Hence, developing novel and efficient therapies seem urgent.
Masoud, Mirghorbani +2 more
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Myeloid derived suppressor cells in transplantation
Current Opinion in Immunology, 2011Myeloid derived suppressor cells (MDSC) are a heterogeneous population of hematopoietic derived cell precursors that can suppress immune responses in a variety of inflammatory settings. Here we review recent studies detailing expansion of phenotypically and functionally disparate MDSC.
Jason R, Lees +2 more
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Myeloid-Derived Suppressor Cells
2007The development of tumor-specific T cell tolerance is largely responsible for tumor escape. Accumulation of myeloid-derived suppressor cells (MDSCs) in animal tumor models as well as in cancer patients is involved in tumor-associated T cell tolerance.
Srinivas, Nagaraj, Dmitry I, Gabrilovich
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Myeloid-derived suppressor cells in transplantation
Current Opinion in Organ Transplantation, 2010Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells that are considered as potential therapeutic targets. Indeed, MDSCs have been shown to suppress immune responses to several types of tumor cells and blocking their suppressive activity may adequately enhance immune response against tumor antigens. On the contrary,
Dilek, Nahzli +3 more
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Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
2020Myeloid-derived suppressor cells (MDSCs) represent a heterogenous population of immature myeloid cells capable of modulating immune responses. In the context of cancer, MDSCs are abnormally produced and recruited to the tumor microenvironment (TME) to aid in the establishment of an immunosuppressive TME that facilitates tumor escape.
Matthew, Dysthe, Robin, Parihar
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Myeloid Derived Suppressor Cells
2016Myeloid derived suppressor cells (MDSCs) comprise a phenotypically heterogeneous population of cells, which can be found in tumor bearing mice and in patients with cancer. MDSCs play a central role in the induction of peripheral tolerance. Together with regulatory T cells (Tregs) they promote an immunosuppressive environment in tumor-bearing hosts.
Taku Fujimura, Alexander H. Enk
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Myeloid-derived suppressor cells: Identification and function
Myeloid-derived suppressor cells (MDSCs) are cells that play a regulatory role in immune responses and inflammation. They can have both positive and negative effects on various diseases, including cancer, infections, sepsis, and trauma. MDSCs inhibit immune cells by releasing immunosuppressive factors and can be categorized as monocytic (M) or ...Paola, Vacca +3 more
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