Results 161 to 170 of about 93,323 (254)

A model to investigate the oncogenic activity of MLL-fusions in Acute Myeloid Leukaemia

, 2009
The MLL gene, located on 11q23, is involved in a large number of chromosomal translocations, including t(9;11)(p22;q23) and t(11;19)(p22;q23). These translocations encode the MLL-AF9 and MLL-ENL fusion transcription factors and are prevalent in infant ...
Walf-Voderwüelbecke, V.
core  

Genome‐wide association study in 21,271 individuals identifies 9 novel loci associated with circulating CD34+ hematopoietic stem and progenitor cell levels

HemaSphere, Volume 10, Issue 7, July 2026.
Yuwen Xie, Antton Lamarca, Caterina Cafaro, Gudmar Thorleifsson, Ludvig Ekdahl, Daniela Torres Di Bello, Zain Ali, Yen La, Lilja Stefansdottir, Alex Antill, Maroulio Pertesi, Maria Laura Mahecha Escobar, Magnús K. Magnússon, Simon N. Stacey, Kari Stefansson, Ingileif Jonsdottir, Göran Karlsson, Thorunn Olafsdottir, Unnur Thorsteinsdottir, Aitzkoa Lopez de Lapuente Portilla, Björn Nilsson   +20 more
wiley   +1 more source

Untersuchungen zur Regulierung und Funktion der Mitogen-aktivierten Proteinkinase ERK5 = Regulation and Function of the Mitogen-activated Protein Kinase ERK5

, 2003
Mitogen activated protein kinases (MAPKs) are found in all eukaryotic cells and represent crucial elements in the signal transduction from the plasma membrane to the nucleus.
Buschbeck, Marcus
core  

Myeloid/lymphoid neoplasm with FLT3 gene fusion: report of a case with a novel t(5;13)(q13;q12) SSBP2::FLT3 fusion. [PDF]

J Hematop
Cook JR, Astbury C, Bosler DS, Molina JC, Rogers HJ, Sobecks RM, Owczarczyk AB.   +6 more
europepmc   +1 more source

The molecular pathogenesis of myeloproliferative neoplasms

, 2010
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological stem cellmalignancies characterised by proliferation of one or more cells of the myeloid lineage.
Jones, Amy Victoria
core  

Co-option of lineage plasticity as a hallmark of multipotent acute leukemias. [PDF]

Blood Neoplasia
Gutierrez A, Kentsis A.
europepmc   +1 more source

A novel JAK1 variant in chronic eosinophilic leukaemia with response to benralizumab

British Journal of Haematology, Volume 209, Issue 1, Page 335-339, July 2026.
Isabel C. Vallecillo‐Viejo, Michael D. Claiborne, Charles F. Anderson, Samantha Shafer, Alan Saven, Bryce A. Seifert, Morgan Similuk, Magdalena Walkiewicz, Irina Maric, Pia R. Crespo, Lori Broderick, Andrew A. White, Amy D. Klion   +12 more
wiley   +1 more source

MPRIP::PDGFRB fusion identified in a male patient with a myeloid/lymphoid neoplasm with eosinophilia. [PDF]

Ann Hematol
Gao M, Bachiashvili K, Jamy O, Harada S, Mackinnon AC, Ravindran A, Chen Y, Carroll AJ, Mikhail FM.   +8 more
europepmc   +1 more source

Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis

, 2008
AML1/RUNX1 is a critical transcription factor in hematopoietic cell differentiation and proliferation. From the _AML1_ gene, at least three isoforms, _AML1a_, _AML1b_ and _AML1c_, are produced through alternative splicing.
Zhen Tian, Haiyan Xing, Xiangrong Liu, Dong-er Zhang, Min Wang, Qing Zhang, Qing Rao, Jianxiang Wang, Chunlin Zhou   +8 more
core   +1 more source

New Bcr-Abl-independent mechanisms of resistance to imatinib treatment in chronic myelogenous leukaemia patients

, 2008
Although rare in chronic phase myeloid leukemia (CML), primary or acquired resistance to the treatment with tyrosine kinase inhibitors (TKI) may be observed in the advanced phases of disease.
Esposito, Nicola
core