Results 71 to 80 of about 117,497 (280)

Functional analysis of the NUP98-CCDC28A fusion protein

Haematologica, 2012
Background The nucleoporin gene NUP98 is rearranged in more than 27 chromosomal abnormalities observed in childhood and adult, de novo and therapy-related acute leukemias of myeloid and T-lymphoid origins, resulting in the creation of fusion genes and ...
Arnaud Petit, Christine Ragu, Gwendoline Soler, Chris Ottolenghi, Caroline Schluth, Isabelle Radford-Weiss, Sylvie Schneider-Maunoury, Isabelle Callebaut, Nicole Dastugue, Harry A. Drabkin, Olivier A. Bernard, Serge Romana, Virginie Penard-Lacronique   +12 more
doaj   +1 more source

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice. [PDF]

PLoS ONE, 2012
Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, which results from the chromosomal translocation t(10;
Mai Suzuki, Hirokazu Tanaka, Akira Tanimura, Kenji Tanabe, Natsuko Oe, Shinya Rai, Syunsuke Kon, Manabu Fukumoto, Kohji Takei, Takaya Abe, Itaru Matsumura, Yuzuru Kanakura, Toshio Watanabe   +12 more
doaj   +1 more source

Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis [PDF]

, 2011
The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4), and Meis1, along with several individual Hox proteins, are implicated in stem cell expansion ...
Alexander Thompson, Belotti D, Buske C, Deschamps J, Edwina Dobbin, Glenda J. Dickson, Helen Wheadon, Joanne M. Ramsey, Lawrence HJ, Pamela M. Corrigan, Robin W. Freeburn   +10 more
core   +1 more source

Evaluating venetoclax and its potential in treatment-naïve acute myeloid leukemia

Cancer Management and Research, 2019
Venetoclax (ABT-199), a BH3-mimetic and selective BCL-2 inhibitor, was recently approved by the US Food and Drug Administration (FDA) for the treatment of acute myeloid leukemia (AML) in adult patients aged 75 years or older, or otherwise unable to ...
Tristan E. Knight, Holly Edwards, J. Taub, Yubin Ge   +3 more
semanticscholar   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

METABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA

Медицинская иммунология, 2014
. We examined metabolic status of blood lymphocytes in forty-four patients with chronic myeloid leukemia (CML), and in fifty-seven patients with chronic lymphoid leukemia (CLL).
O. V. Smirnova, V. T. Manchuk, A. A. Savchenko   +2 more
doaj   +1 more source

The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]

, 2012
Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
A Quintas-Cardama, A Zipursky, AG Muntean, AG Muntean, Brenda Gibson, C Halsey, C Kuhl, Christina Halsey, CS McKimmie, Derek Gilchrist, Gerard Graham, H Sakamoto, I Matsumura, J Wechsler, JD Crispino, JP Bourquin, K Georgopoulos, KA Alford, L Gutierrez, LC Andersson, LM Hollanda, M Ritter, Marie Docherty, ME Greene, Mhairi McNeill, Michelle Le Brocq, N Shimokawa, N Suzuki, N Ueki, O Tunstall-Pedoe, PA Tetteroo, R Alitalo, R Calligaris, R Ferreira, RA Shivdasani, S Pearson-White, S Teichler, T Nomura, Y Ge, Z Li   +39 more
core   +2 more sources

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Regulation of hematopoietic and leukemia stem cells by regulatory T cells

Frontiers in Immunology, 2022
Adult bone marrow (BM) hematopoietic stem cells (HSCs) are maintained in a quiescent state and sustain the continuous production of all types of blood cells.
Carsten Riether, Carsten Riether
doaj   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source