Results 81 to 90 of about 183 (135)
MedComm, Volume 7, Issue 9, September 2026.This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng +9 more
wiley +1 more source
Evaluating venetoclax and its potential in treatment-naïve acute myeloid leukemia
Cancer Management and Research, 2019 Tristan Knight,1,2 Holly Edwards,3,4 Jeffrey W Taub,1–2,4 Yubin Ge2–41Division of Pediatric Hematology and Oncology, Department of Pediatrics, Children’s Hospital of Michigan, Detroit, MI, USA; 2Department of Pediatrics, Wayne State ...
Knight T, Edwards H, Taub JW, Ge Y
doaj
MedComm – Oncology, Volume 5, Issue 3, September 2026.Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K +5 more
wiley +1 more source
Nature CommunicationsSingle-cell transcriptome profiling enables unparalleled characterization of the heterogeneous microenvironment of pediatric leukemias. To facilitate comparative analyses and generate pediatric leukemia signatures, we collect, process, and annotate ...
Hope L. Mumme +12 more
doaj +1 more source
Fusion Gene KMT2A::SEPTIN6 in Acute Myeloid Leukemia Cell Line KOPM-88
Cells(1) Background: KMT2A (alias MLL) is located at chromosome 11q23 and encodes histone methyltransferase 2A which activates target genes via chromatin methylation of histone H3 lysine K4.
Stefan Nagel +7 more
doaj +1 more source
Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 3, September 2026.Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley +1 more source
Rare TumorsBackground Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm driven by the Philadelphia chromosome, typically progressing through chronic, accelerated, and blast phases. Blast crisis may be myeloid or lymphoid.
Álvaro Zarama-Valenzuela +3 more
doaj +1 more source
Histiocytosis development and clinical variation through the lens of genomics
The Journal of Pathology, Volume 270, Issue 1, Page 23-39, September 2026.Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps +3 more
wiley +1 more source
Cancer heterogeneity explored through immune cell deconvolution of the tumor microenvironment
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Cancer is a highly heterogeneous disease, characterized by significant variability across multiple dimensions. This diversity has been extensively studied from various perspectives. In this study, we aim to examine cancer heterogeneity through the lens of immune cell composition within the tumor microenvironment.
Limin Jiang +4 more
wiley +1 more source
Myeloid-lymphoid or mixed-lineage leukemia (MLL; HRX); heat shock protein 90 (Hsp90) [PDF]
Science-Business eXchange, 2014 openaire +1 more source