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CD1c(+) myeloid dendritic cells in myeloid neoplasia
Cytometry Part B: Clinical Cytometry, 2015We determined the normal level and phenotype of CD1c(+) myeloid dendritic cells (MDCs) in blood and bone marrow and evaluated the level of CD1c(+) MDCs in 295 myeloid neoplasms. CD1c(+) MDCs were increased above the mean level of non‐neoplastic hospital controls in 18.0% (53/295) of myeloid malignancies, increased three standard deviations above the ...
Howard J, Meyerson +7 more
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Science, 2017
Innate Immunity Hematopoietic stem cells are a common progenitor of adaptive and innate immune cells. However, the precise factors that guide differentiation down these disparate pathways remain unclear, in part owing to difficulties in working with small numbers of precursor cells. Lee et al .
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Innate Immunity Hematopoietic stem cells are a common progenitor of adaptive and innate immune cells. However, the precise factors that guide differentiation down these disparate pathways remain unclear, in part owing to difficulties in working with small numbers of precursor cells. Lee et al .
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The Myeloid Cell Compartment—Cell by Cell
Annual Review of Immunology, 2019Myeloid cells are a major cellular compartment of the immune system comprising monocytes, dendritic cells, tissue macrophages, and granulocytes. Models of cellular ontogeny, activation, differentiation, and tissue-specific functions of myeloid cells have been revisited during the last years with surprising results; for example, most tissue macrophages ...
Baßler, Kevin +4 more
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Myeloid Cell Actinomycin Binding in Human Myeloid Leukaemia
Acta Haematologica, 1974Decreased actinomycin D binding was observed in the marrow cells of some patients with chronic myeloid leukaemia.
A, Pileri +3 more
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The Journal of Immunology, 2016
Abstract Inhalation of Francisella tularensis (Ft) causes acute and fatal pneumonia. The lung cytokine milieu favors exponential Ft replication, but mechanisms underlying acute pathogenesis and death remain unknown. Evaluation of the sequential and systemic host immune response in pulmonary tularemia reveals that an overt innate cellular
Sivakumar Periasamy +4 more
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Abstract Inhalation of Francisella tularensis (Ft) causes acute and fatal pneumonia. The lung cytokine milieu favors exponential Ft replication, but mechanisms underlying acute pathogenesis and death remain unknown. Evaluation of the sequential and systemic host immune response in pulmonary tularemia reveals that an overt innate cellular
Sivakumar Periasamy +4 more
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Myeloid-Derived Suppressor Cells
2007The development of tumor-specific T cell tolerance is largely responsible for tumor escape. Accumulation of myeloid-derived suppressor cells (MDSCs) in animal tumor models as well as in cancer patients is involved in tumor-associated T cell tolerance.
Srinivas, Nagaraj, Dmitry I, Gabrilovich
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Cardioprotective myeloid cells
Science, 2020Inflammation Acute ischemic injury to the heart precipitates a strong inflammatory response, including influx of myeloid cells expressing type I interferon–stimulated genes (ISGs). Calcagno et al. used single-cell RNA sequencing to probe the origin, evolution, and heterogeneity of this response in the first 4 days after myocardial infarction using ...
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Acute Myeloid Leukemia Stem Cells
Annals of the New York Academy of Sciences, 2005Abstract:A fundamental problem in cancer research is identification of the cells within a tumor that sustain the growth of the neoplastic clone. The concept that only a subpopulation of rare cancer stem cells (CSCs) is responsible for maintenance of the neoplasm emerged nearly 50 years ago; however, conclusive proof for the existence of a CSC was ...
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Chronic Myeloid Leukemia Stem Cells
Hematology, 2008AbstractChronic myeloid leukemia (CML) is typified by robust marrow and extramedullary myeloid cell production. In the absence of therapy or sometimes despite it, CML has a propensity to progress from a relatively well tolerated chronic phase to an almost uniformly fatal blast crisis phase.
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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