Results 231 to 240 of about 126,969 (246)

Dendritic cell vaccination in acute myeloid leukemia

Cytotherapy, 2012
The prognosis of patients with acute myeloid leukemia (AML) remains dismal, with a 5-year overall survival rate of only 5.2% for the continuously growing subgroup of AML patients older than 65 years. These patients are generally not considered eligible for intensive chemotherapy and/or allogeneic hematopoietic stem cell transplantation because of high ...
Anguille, Sébastien, Willemen, Yannick, Lion, Eva, Smits, Evelien, Berneman, Zwi Nisan   +4 more
openaire   +3 more sources

Differentiation of myeloid dendritic cells into CD8α-positive dendritic cells in vivo

Blood, 2000
AbstractBone marrow-derived dendritic cells (DC) represent a family of antigen-presenting cells (APC) with varying phenotypes. For example, in mice, CD8α+ and CD8α− DC are thought to represent cells of lymphoid and myeloid origin, respectively. Langerhans cells (LC) of the epidermis are typical myeloid DC; they do not express CD8α, but they do express ...
M, Merad, L, Fong, J, Bogenberger, E G, Engleman   +3 more
openaire   +2 more sources

Tai Chi Chuan Increases Circulating Myeloid Dendritic Cells

Immunological Investigations, 2010
Dendritic cells, the most potent antigen-presenting cells linking innate and adoptive immunity, are thought to be important targets of immune modulators such as exercise. We examined the effect of Tai Chi Chuan (TCC) on dendritic cells. TCC practitioners were further divided to high-level practitioners (TCC-H) and low-level practitioners (TCC-L).
Jasson, Chiang, Yu-Yawn, Chen, Takafuji, Akiko, Yu-Chuen, Huang, Ming-Ling, Hsu, Tsong-Rong, Jang, Yu-Jen, Chen   +6 more
openaire   +2 more sources

Myeloid dendritic cells type 2 in allergic asthma

Allergy, 2013
AbstractBackgroundMyeloid dendritic cells type 2 (mDC2s) are a new subtype of DCs identified in both the circulation and the lung and suggested to have a role in allergic asthma.MethodsCirculating mDC2s were enumerated in 19 healthy, 18 atopic nonasthmatic, 18 mild atopic asthmatic, and 16 moderate/severe atopic asthmatic subjects using flow cytometry ...
Dua, B., Smith, S., Kinoshita, T., Imaoka, H., Gauvreau, G., O'Byrne, P.   +5 more
openaire   +2 more sources

Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells

Blood, 2008
Abstract The migratory properties of dendritic cells (DCs) are important for their functions. Although several chemokines and their receptors have been implicated in DC migration, the downstream signaling molecules are largely unknown.
Kazuhito, Gotoh, Yoshihiko, Tanaka, Akihiko, Nishikimi, Ayumi, Inayoshi, Munechika, Enjoji, Ryoichi, Takayanagi, Takehiko, Sasazuki, Yoshinori, Fukui   +7 more
openaire   +2 more sources

FUNCTION OF MYELOID DENDRITIC CELLS

2012
Approximately 70% of patients infected with hepatitis C virus (HCV) develop chronic infection, which has been reported to be due to impaired specific T cell responses. Myeloid dendritic cells (mDCs) are potent antigen-presenting cells that regulate T cell responses, however their role during chronic hepatitis C (CHC) is not fully understood.
openaire   +1 more source

Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells

Blood, 2003
To exploit a novel strategy to regulate T cell–mediated immunity, we established human and murine modified dendritic cells (DCs) with potent immunoregulatory properties (designed as regulatory DCs), which displayed moderately high expression levels of major histocompatibility complex (MHC) molecules and extremely low levels of costimulatory molecules ...
Katsuaki, Sato, Naohide, Yamashita, Masanori, Baba, Takami, Matsuyama   +3 more
openaire   +2 more sources

Dendritic cells of myeloid lineage

Current Opinion in Organ Transplantation, 2014
Advances in surgery, patient management, and pharmacologic immunosuppression have reduced the incidence of acute allograft rejection. However, generation of therapies to promote donor-specific immunosuppression with minimal side-effects has proved to be a difficult task.
openaire   +2 more sources

IFN regulation and functions in myeloid dendritic cells

Cytokine & Growth Factor Reviews, 2008
A central issue in dendritic cells (DC) biology is to understand how type I IFNs modulate the immuno-regulatory properties of DC. In this review I will address this issue in light of the recent experimental evidence on the expression and function of these cytokines in myeloid DC.
openaire   +2 more sources

Human myeloid dendritic cells are refractory to tryptophan metabolites

Human Immunology, 2011
The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan and is expressed, among other cell types, in immune cells such as dendritic cells (DCs), monocytes, and macrophages. It has been shown that the activity of IDO has a broad regulatory function in the immune system by inhibiting effector T-cell responses, inducing ...
Dagmar, von Bubnoff, Helene, Wilms, Marina, Scheler, Manuela, Brenk, Susanne, Koch, Thomas, Bieber   +5 more
openaire   +2 more sources