Results 91 to 100 of about 414,323 (331)

Acute kidney injury in critically ill cancer patients : an update [PDF]

, 2016
Patients with cancer represent a growing group among actual ICU admissions (up to 20 %). Due to their increased susceptibility to infectious and noninfectious complications related to the underlying cancer itself or its treatment, these patients ...
Benoit, Dominique, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond   +3 more
core   +2 more sources

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death

Blood Cancer Journal
Highlights CD73 is the key ectoenzyme involved in the generation of AMP-derived adenosine, which contributes to immunosuppression in the MM BM milieu. Blocking CD73 activity with a potent, selective, orally bioavailable CD73 inhibitor ORIC-533 decreases ...
Arghya Ray, Ting Du, Xueping Wan, Yan Song, Sindhu C. Pillai, Md. Abu Musa, Teng Fang, Jared Moore, Brian Blank, Xiaohui Du, Xi Chen, Robert Warne, Dena Sutimantanapi, Fang Lui, Tatiana Zavorotinskaya, Christophe Colas, Lori Friedman, Melissa R. Junttila, Dharminder Chauhan, Kenneth C. Anderson   +19 more
doaj   +1 more source

Chimeric antigen receptor (CAR) -T cell therapy treatment Richter's transformation

Frontiers in Oncology
Background/purposeDespite advances in chronic lymphocytic leukemia treatment, effective therapies for cases with Richter’s transformation (RT) are urgently needed. This study aimed to investigate the use of chimeric antigen receptor (CAR)-T cell infusion
Shaomei Feng, Peihao Zheng, Haidi Liu, Meiling Sun, Yuelu Guo, Lixia Ma, Rui Liu, Zhonghua Fu, Fan Yang, Xiaoyan Ke, Kai Hu   +10 more
doaj   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

Combination autologous stem cell transplantation with chimeric antigen receptor T-cell therapy for refractory/relapsed B-cell lymphoma: a single-arm clinical study

Frontiers in Immunology
Autologous stem cell transplantation (ASCT) and chimeric antigen receptor T-cells (CAR-T) have been used as consolidation therapies for patients with refractory/relapsed B cell non-Hodgkin’s lymphoma (R/R B-NHL) in remission after second-line ...
Danyang Li, Rui Liu, Zhonghua Fu, Fan Yang, Lixia Ma, Yuelu Guo, Miaomiao Cao, Yang Lei, Yimeng Dou, Xuenan Zhang, Yan Gao, Bian Wei, Biping Deng, Xiaoyan Ke, Xiaoyan Ke, Kai Hu   +15 more
doaj   +1 more source

Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells [PDF]

, 2017
Docosahexaenoic acid (DHA), a ω-3 polyunsaturated fatty acid found in fish oil, is a multi-target agent and exerts anti-inflammatory and anticancer activities alone or in combination with chemotherapies.
D'Eliseo, Donatella, DI RENZO, Livia Maria, Santoni, Angela, Velotti, Francesca   +3 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Metronomic therapy is an effective salvage treatment for heavily pre-treated relapsed/refractory multiple myeloma

Haematologica, 2013
Relapsed/refractory multiple myeloma represents a major challenge in multiple myeloma therapy. For patients with relapsed/refractory multiple myeloma, we developed a treatment schema of metronomically scheduled drug therapy.
Xenofon Papanikolaou, Jackie Szymonifka, Adam Rosenthal, Christoph J. Heuck, Alan Mitchell, Donald Johann, Jason Keller, Sarah Waheed, Saad Z. Usmani, Frits Van Rhee, Clyde Bailey, Nathan Petty, Antje Hoering, John Crowley, Bart Barlogie   +14 more
doaj   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source