Results 61 to 70 of about 338,912 (243)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Acute liver failure precipitated by acute Budd‐Chiari syndrome and complete portal vein thrombosis

Clinical Case Reports, 2021
Acute Budd‐Chiari syndrome and complete portal vein thrombosis are important features of myeloproliferative neoplasm that may occur simultaneously, resulting in acute liver failure.
Yuji Suzuki, Akiko Suzuki, Keisuke Kakisaka, Yasuhiro Takikawa   +3 more
doaj   +1 more source

Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations

Leukemia Research Reports, 2023
We report a case of myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement (MLNZMYM2::FGFR1) exhibiting a complex disease evolution. This neoplasm initially presented as T-lymphoblastic lymphoma (T-LBL) in lymph node and myeloproliferative neoplasm ...
Dong Chen, Guang Liu, Michael R. Lewis, Xia Li, Matthew Ulrickson, Rajneesh Nath, Weina Chen   +6 more
doaj   +1 more source

Incidence patterns and temporal trends of childhood cancer in Germany, 1980–2019: Forty years of childhood cancer registration in Germany

International Journal of Cancer, EarlyView.
What's New? Childhood cancer ranks among the leading causes of disease‐related deaths in children in high‐income countries. Established risk factors, however, account for only a small proportion of incident childhood cancers. In this report, the authors present the first long‐term assessment of temporal trends in childhood cancer incidence rates in ...
Friederike Erdmann, Maike Wellbrock, Claudia Trübenbach, Desiree Grabow, Martin Schrappe, Peter Kaatsch, Claudia Spix, Joachim Schüz, Cécile M. Ronckers   +8 more
wiley   +1 more source

Mutational landscape of myelodysplastic/myeloproliferative neoplasm-unclassifiable.

Blood, 2018
TO THE EDITOR: The “unclassifiable” myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U) remain the most poorly characterized among the various subtypes of MDS/MPN.[1][1] Retrospective studies have reported the median survival of patients with MDS ...
P. Bose, A. Nazha, R. Komrokji, K. Patel, S. Pierce, Najla Al-Ali, A. Sochacki, Aaron C. Shaver, Wencai Ma, X. Su, N. Daver, C. Dinardo, G. Garcia-Manero, S. Loghavi, C. Bueso-Ramos, H. Kantarjian, M. Sekeres, M. Savona, J. Maciejewski, S. Verstovsek   +19 more
semanticscholar   +1 more source

Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms

Haematologica, 2017
High mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that is negatively regulated by let-7 microRNA through binding to it’s 3′-untranslated region. Transgenic mice expressing Hmga2 with a truncation of its 3′-untranslated region
Chih-Cheng Chen, Jie-Yu You, Jrhau Lung, Cih-En Huang, Yi-Yang Chen, Yu-Wei Leu, Hsing-Ying Ho, Chian-Pei Li, Chang-Hsien Lu, Kuan-Der Lee, Chia-Chen Hsu, Jyh-Pyng Gau   +11 more
doaj   +1 more source

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

International Journal of Cancer, EarlyView.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger, Guillermo Garcia‐Manero, Robert Zeiser, Michael Lübbert   +3 more
wiley   +1 more source

Arterial and Venous Thrombosis in Patients with Myeloproliferative Neoplasms

Jurnal Penyakit Dalam Indonesia, 2019
Introduction. Myeloproliferative neoplasm (MPN) is a hematologic disorder that consists of polycythemia vera (PV), essential thrombocythemia (ET and primary myelofibrosis (PMF) and complication of thrombosis is frequently found in patients with MPN. This
Lugyanti Sukrisman
doaj   +1 more source

MDS/MPN With SF3B1 Mutation and Thrombocytosis but Without Ring Sideroblasts

American Journal of Hematology, EarlyView.
Biswadip Hazarika, Barbara J. Bain
wiley   +1 more source

Global, Regional, and National Burden of Cancer in the Elderly Population, 1990–2021: Analysis of Data From the Global Burden of Disease Study 2021

Med Research, EarlyView.
ABSTRACT With the global aging trend intensifying, cancer presents a significant health challenge for the elderly. This study aims to assess the prevalence, mortality, and disability‐adjusted life years (DALY) burden of cancer among individuals aged 60–94 worldwide from 1990 to 2021.
Xiaohan Zhu, Xinya Che, Ruonan Yang, Boyi Bao, Guangdi Chu   +4 more
wiley   +1 more source