Results 141 to 150 of about 1,794 (168)

Presurgical miR‐675‐5p Associates With the Inflammatory Response Following Surgery and Increases Inflammatory Gene Expression In Vitro

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background A loss of muscle mass and strength is a marker of poor outcomes following surgery. Changes in muscle gene expression following surgery are likely to contribute to postsurgical muscle loss, but the mechanisms controlling these changes are not known. We have previously shown that miRNAs associate with muscle loss in disease, including
Narmin Akhundova, Richard Paul, Benjamin Fletcher, Martin Connolly, Mark J. Griffiths, Paul R. Kemp   +5 more
wiley   +1 more source

Modular Tissue‐Engineered Motor Units Featuring Spinal Motor Neurons Innervating Self‐Assembled Myofiber Bundles

Macromolecular Bioscience, Volume 26, Issue 8, August 2026.
The current study devised a methodology to biofabricate pre‐innervated, three‐dimensional bundled myofibers, as shown in this confocal micrograph depicting immunolabeled axons (red) and a multinucleated (blue) myofiber with well‐defined sarcomeres (green). ABSTRACT A motor unit is the functional unit of muscle contraction, consisting of a population of
Melanie C. Hilman, Elizabeth N. Krizman, Foteini Mourkioti, Suradip Das, D. Kacy Cullen   +4 more
wiley   +1 more source

Loss of Rab8a‐Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia–Reoxygenation Injury

MedComm, Volume 7, Issue 8, August 2026.
Rab8a‐dependent tethering of lipid droplets to mitochondria sustains fatty acid oxidation and cardiomyocyte metabolic flexibility under normoxia. During hypoxia/reoxygenation, Rab8a loss and PLIN5‐associated lipophagy uncouple lipid breakdown from mitochondrial utilization, driving lipotoxicity and cell death.
Jialing Tang, Nathan Joyce, Thomas Laval, Eddie Tam, Hye Kyoung Sung, Mireille Ouimet, Gary Sweeney   +6 more
wiley   +1 more source

Caspase‐mediated cleavage events hidden by secondary proteolysis during apoptosis

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Caspases are cysteine proteases that cleave specific proteins to control a range of cellular processes including cell death, inflammation, and differentiation. Proteomic approaches, like N‐terminomics, have been central to identifying both cleaved proteins and where they are cleaved.
Fatemeh Fotouhi, Erik Gomez‐Cardona, Jainilkumar Patel, Olivier Julien, Howard Fearnhead   +4 more
wiley   +1 more source

Wavelet Transform‐Based Atomic Force Microscopy: A Computational Paradigm for Dynamic Nanoscale Imaging and Characterisation

Small Science, Volume 6, Issue 8, August 2026.
Wavelet transform‐based AFM enables real‐time nanoscale imaging by applying wavelet analysis to raw cantilever deflection signals. It reveals non‐linear, transient and multi‐frequency dynamics beyond conventional steady‐state methods. Integrated with adaptive filtering and digital twin modelling, it produces high‐resolution, information‐rich maps of ...
Pardis Biglarbeigi, Navneet Soin, Amit Kumar, Dewar Finlay, Amir Farokh Payam   +4 more
wiley   +1 more source

Harnessing 3D Bioprinted Hydrogels With Polydeoxyribonucleotide for Effective Recovery of Volumetric Muscle Loss

Small Structures, Volume 7, Issue 8, August 2026.
3D Bioprinted GelMA hydrogels incorporating polydeoxyribonucleotide (PDRN) offer a promising strategy for recovering volumetric muscle loss. This study reveals that single‐stranded PDRN significantly enhances myogenesis and accelerates muscle remodeling compared to double‐stranded forms.
Elif Beyza Demiray, Juyoung Hwang, Seung Eun Baek, Soyun Lee, Nuri Oh, Hee Jeong Jang, Yun Hak Kim, Jungeun Choi, Seung Yun Nam, Moon Sung Kang, Dong‐Wook Han, Minseok Kwak   +11 more
wiley   +1 more source

The Divergent Effects of Nicotinamide Riboside and High‐Intensity Exercise Training on Skeletal Muscle Epigenetic Aging

Aging Cell, Volume 25, Issue 8, August 2026.
This study investigated the effects of nicotinamide riboside supplementation and high‐intensity interval training on skeletal muscle epigenetic aging. Our findings reveal that both interventions may modify epigenetic aging, with the muscle‐specific MEAT and DunedinPACE clocks showing the most responsiveness and links to mitochondrial abundance ...
Aino Heikkinen, Liina Uusitalo‐Kylmälä, Ida Blom, Jørn Wulff Helge, Linn Gillberg, Robert Seaborne, Steen Larsen, Macsue Jacques, Robin Grolaux, Sari Aaltonen, Jaakko Kaprio, Birgitta W. van der Kolk, Sini Heinonen, Nir Eynon, Kirsi H. Pietiläinen, Riikka Kivelä, Eija Pirinen, Miina Ollikainen   +17 more
wiley   +1 more source

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

Aging Cell, Volume 25, Issue 8, August 2026.
Skeletal muscle aging is associated with a decrease in expression of the lactate receptor GPR81. Treating senescent myoblasts in vitro and progeric mice in vivo with GPR81 agonist decreases intramyocellular lipid accumulation and reverses hallmarks of aging. ABSTRACT Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis,
Pihu Mehrotra, Sai Harsha Bhamidipati, Pedro Lei, John Toftegaard, Debanik Choudhury, Maryam Elsayed, Yali Zhang, Jianmin Wang, Shweta Chitkara, G. Ekin Atilla‐Gokcumen, Song Liu, Stelios T. Andreadis   +11 more
wiley   +1 more source

Diosgenin Alleviates Age‐Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC‐1α Signaling Pathway

Aging Cell, Volume 25, Issue 8, August 2026.
As a critical bioactive component of Polygonatum sibiricum, diosgenin improves age‐related declines in skeletal muscle mass and function by activating the SIRT1/PGC‐1α pathway, upregulating the expression of the myokine METRNL and IGF‐1, and promoting satellite cell proliferation and myogenic differentiation.
Xin Zeng, Han Ding, Ziye Li, Qian Wang, Peiyao Guan, Tingting Wang, Jiayun Wang, Yansong Fu, Lizhang Chen, Hong Qin   +9 more
wiley   +1 more source

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Mechanisms regulating myoblast fusion: A multilevel interplay

Seminars in Cell and Developmental Biology, 2020
Maria Jolanta Rędowicz, Lilya Lehka
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