Results 91 to 100 of about 83,456 (310)

Mechanism of inhibiting acetyl CoA carboxylase 2 to improve cardiac dysfunction in septic mice

陆军军医大学学报
Objective To observe the ameliorative effect of inhibiting acetyl-CoA carboxylase 2(ACC2) on cardiac dysfunction in septic mice and investigate its underlying mechanism.
DU Yunxia, DU Yunxia, SHE Han, SHE Han, WU Yinyu   +4 more
doaj   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

The Effect of Ivabradine on the Human Atrial Myocardial Contractility in an In Vitro Study

Cardiology Research and Practice, 2019
Purpose. Ivabradine has emerged as a new antiarrhythmic agent that could compete with the traditional ones, such as beta-blockers. This experimental study aims to ascertain whether ivabradine directly interferes with the myocardial contractility in an in
Ryan Chaban, Katja Buschmann, Anna Krausgrill, Andres Beiras-Fernandez, Christian-Friedrich Vahl   +4 more
doaj   +1 more source

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

Advanced Science, EarlyView.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin, Chuling Li, Zhaoyi Wu, Zhenquan Tang, Jingfang Xie, Guoquan Wei, Zhiwen Yang, Senlin Huang, Yijin Chen, Xinzhong Li, Yanmei Chen, Wangjun Liao, Yulin Liao, Guojun Chen, Hao Zheng, Jianping Bin   +15 more
wiley   +1 more source

Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats

Frontiers in Cardiovascular Medicine
Background and aimsIschemic preconditioning (IPC), i.e., brief periods of ischemia, protect the heart from subsequent prolonged ischemic injury, and reduces infarction size. Myocardial stunning refers to transient loss of contractility in the heart after
Ahmed Elmahdy, Ahmed Elmahdy, Aaron Shekka Espinosa, Aaron Shekka Espinosa, Yalda Kakaei, Yalda Kakaei, Tetiana Pylova, Tetiana Pylova, Abhishek Jha, Abhishek Jha, Ermir Zulfaj, Maryna Krasnikova, Maryna Krasnikova, Amin Al-Awar, Amin Al-Awar, Zahra Sheybani, Zahra Sheybani, Valentyna Sevastianova, Valentyna Sevastianova, Evelin Berger, Amirali Nejat, Linnea Molander, Linnea Molander, Erik Axel Andersson, Erik Axel Andersson, Elmir Omerovic, Elmir Omerovic, Shafaat Hussain, Shafaat Hussain, Björn Redfors, Björn Redfors, Björn Redfors   +31 more
doaj   +1 more source

Stroke volume and myocardial contraction fraction in transthyretin amyloidosis cardiomyopathy: A systematic review. [PDF]

Front Cardiovasc Med, 2023
Matteo S, Anna C, Federico S, Daniele M, Gioele F, Beatrice DP, Rita P, Elisabetta T, Giulia P, Claudio R, Gianluca C.   +10 more
europepmc   +1 more source

Deep Learning for Multi-Level Detection and Localization of Myocardial Scars Based on Regional Strain Validated on Virtual Patients [PDF]

IEEE Access, Date of Publication: 08 February 2023, Electronic ISSN: 2169-3536, Volume 11, Page(s): 15788 - 15798
How well the heart is functioning can be quantified through measurements of myocardial deformation via echocardiography. Clinical assessment of cardiac function is generally focused on global indices of relative shortening, however, territorial, and segmental strain indices have shown to be abnormal in regions of myocardial disease, such as scar.
arxiv   +1 more source

Advancements in Bio‐Integrated Flexible Electronics for Hemodynamic Monitoring in Cardiovascular Healthcare

Advanced Science, EarlyView.
This review explores the cutting‐edge development of bio‐integrated flexible electronics for real‐time hemodynamic monitoring in cardiovascular healthcare. It covers key physiological indicators, innovative sensing mechanisms, and materials considerations. This paper highlights the application of both invasive and non‐invasive devices in cardiovascular
Ke Huang, Zhiqiang Ma, Bee Luan Khoo
wiley   +1 more source

Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Left ventricular (LV) diastolic dysfunction often precedes heart failure with preserved ejection fraction, the dominant form of heart failure in postmenopausal women.
Kristofer T. Michalson, Leanne Groban, Timothy D. Howard, Carol A. Shively, Areepan Sophonsritsuk, Susan E. Appt, J. Mark Cline, Thomas B. Clarkson, J. Jeffrey Carr, Dalane W. Kitzman, Thomas C. Register   +10 more
doaj   +1 more source

Label-free evaluation of myocardial infarct in surgically excised ventricular myocardium by Raman spectroscopy [PDF]

arXiv, 2018
Understanding the viability of the ischemic myocardial tissue is a critical issue in determining the appropriate surgical procedure for patients with chronic heart failure after myocardial infarction (MI). Conventional MI evaluation methods are; however, preoperatively performed and/or give an indirect information of myocardial viability such as shape,
arxiv