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New England Journal of Medicine, 2007 Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of the injury, on attempts to protect the heart against it, and on promising new approaches to cardioprotection during percutaneous coronary intervention.
Derek M, Yellon, Derek J, Hausenloy
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Myocardial ischemia – reperfusion injury
Zaporozhye Medical Journal, 2023 Aim. To summarize and broaden the idea about mechanisms of acute coronary insufficiency development and pathophysiological features of myocardial reperfusion injury. Today, in the event of acute coronary syndrome, according to the latest recommendations for myocardial revascularization, percutaneous coronary intervention should be performed to ...
S. V. Salo +3 more
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Myocardial reperfusion injury [PDF]
European Heart Journal Supplements, 2002 Post-ischaemic reperfusion carries an injurious component that may partly counteract the beneficial effects of reflow; this component has been termed ‘reperfusion injury’. Principal mediators of this phenomenon are oxygen radicals and neutrophils. Oxygen radicals, generated in large amounts upon reflow, induce oxidative tissue damage and modulate ...
AMBROSIO, Giuseppe, TRITTO, Isabella
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Lethal Myocardial “Reperfusion Injury” [PDF]
Journal of Thrombosis and Thrombolysis, 1997 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/48021/1/11239_2004_Article_255436 ...
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Reperfusion injury after acute myocardial infarction [PDF]
BMJ, 1995 The restoration of oxygenated blood to ischaemic myocardium—reperfusion—halts the process leading to infarction. Early reperfusion is the only way to prevent progression to myocardial necrosis and thus to limit the size of the infarct. It may also, however, injure the heart.
E D, Grech, M J, Jackson, D R, Ramsdale
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Platelets in Myocardial Ischemia/Reperfusion Injury
Hämostaseologie, 2022 AbstractCoronary artery disease, including myocardial infarction (MI), remains a leading cause of global mortality. Rapid reperfusion therapy is key to the improvement of patient outcome but contributes substantially to the final cardiac damage. This phenomenon is called “ischemia/reperfusion injury (IRI).” The underlying mechanisms of IRI are complex ...
Schanze, Nancy +4 more
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Curcumin attenuates myocardial ischemia-reperfusion injury
Oncotarget, 2017 Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world.Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated.The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ...
Liu, Kun +8 more
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Anaesthesia and myocardial ischaemia/reperfusion injury [PDF]
British Journal of Anaesthesia, 2009 Anaesthetists are confronted on a daily basis with patients with coronary artery disease, myocardial ischaemia, or both during the perioperative period. Therefore, prevention and ultimately adequate therapy of perioperative myocardial ischaemia and its consequences are the major challenges in current anaesthetic practice.
J, Frässdorf, S, De Hert, W, Schlack
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Myocardial reperfusion injury: a new view [PDF]
Cardiovascular Research, 2004 Acute coronary occlusion resulting in myocardial infarction is the main mechanism by which coronary artery disease reduces survival and leads to deterioration of the quality of life, and the extent of cell death is the main determinant of survival in patients with acute myocardial infarction.
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Down’s syndrome and myocardial reperfusion injury
Journal of the Saudi Heart Association, 2011 Down syndrome is known to be an independent risk factor for mortality after surgical repair of congenital heart anomalies. It is also associated with neurodegenerative disease and accelerated aging. The mechanism of the latter features has been attributed to abnormal handling of oxygen-free radicals as well as mitochondrial dysfunction.
Kumar, Susheel, Jonas, Richard
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