Results 271 to 280 of about 282,175 (385)

Saline‐based modified del Nido cardioplegia versus multidose St. Thomas cardioplegia in canine mitral valve repair: A randomized controlled trial

open access: yesVeterinary Surgery, EarlyView.
Abstract Objective To compare the utility of a saline‐based modified del Nido (mDN) cardioplegia solution with a conventional institutional technique (multidose St. Thomas blood cardioplegia) for mitral valve repair (MVR) in dogs. Study design Prospective, randomized, open‐label trial.
Kentaro Kurogochi   +7 more
wiley   +1 more source

The role of orexin A in the pathogenesis of ischaemic stroke at high altitude

open access: yesExperimental Physiology, EarlyView.
Schematic illustration of the experimental design. This study investigated the role of Orexin A in the pathogenesis of ischemic stroke at high altitude. Abstract Orexin offers protection against cerebral ischaemia–reperfusion injury, with high altitude playing a key role in modulating its expression.
Minxia Zhu   +7 more
wiley   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich   +5 more
wiley   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

open access: yesMedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia   +4 more
wiley   +1 more source

Leukocyte trafficking and myocardial reperfusion injury in ICAM-1/P-selectin-knockout mice

open access: bronze, 2001
Stéphanie A. Briaud   +5 more
openalex   +1 more source

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