Results 271 to 280 of about 130,617 (289)
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Pharmacological therapy for myocardial reperfusion injury
Current Opinion in Pharmacology, 2004In the ischemic myocardium, reperfusion is necessary for the salvage of cells and cardiac function. However, reperfusion itself causes 'reperfusion injury', leading to the damage of myocardial cells. This is reduced by several interventions, as measured by the limitation of infarct size or reduction of arrhythmias.
George V, Moukarbel +2 more
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Reperfusion injury, stunning and myocardial viability
Australian and New Zealand Journal of Medicine, 1993Abstract:Recent experimental data suggest that current thrombolytic strategies may not yet have achieved their full potential for myocardial salvage. In fact, reperfusion may result in microvascular and myocardial cellular injuries. These may translate into transient loss of contractile function (‘myocardial stunning’), and possibly contribute to the ...
A, Tonkin, R, Chan
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C5aR-mediated myocardial ischemia/reperfusion injury
Biochemical and Biophysical Research Communications, 2007The complement system activation can mediate myocardial ischemia and reperfusion (I/R). Inhibition of C5a activity reveals attenuation of I/R-induced myocardial infarct size. However, the contribution of C5a receptor (C5aR) to I/R injury remains to be unknown.
Haimou, Zhang +5 more
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Zinc and myocardial ischemia/reperfusion injury
BioMetals, 2013As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors.
Zhelong, Xu, Juan, Zhou
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Lethal Myocardial Reperfusion Injury
2012Early coronary artery reperfusion reduces infarct size and mortality and improves left ventricular contractile performance after myocardial ischemia compared to permanent occlusion. However, reperfusion itself causes either an acceleration of injury that is not present during ischemia or causes de novo reversible and lethal injury to heart tissue.
Jakob Vinten-Johansen +3 more
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Clarithromycin attenuates myocardial ischemia–reperfusion injury
Expert Opinion on Therapeutic Targets, 2010MMP activity is upregulated in the heart after myocardial ischemia reperfusion, and its activation contributes to the changes in left ventricular (LV) dysfunction. A major macrolide antibiotic, clarithromycin has many biological functions including MMP regulation.
Takuya, Nakajima +10 more
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Unresolved issues in myocardial reperfusion injury
Cardiovascular Pathology, 2010While the basic pathobiology of myocardial ischemic injury and reperfusion has been determined over the last 50 years, there are important, unresolved, or at least not completely elucidated, issues in the field. These include the relative contributions of different modes of cell injury and death to evolving myocardial infarcts; interactions of ...
Louis Maximilian, Buja +1 more
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Myocardial Reperfusion Injury: The Critical Challenge
Critical Care Nursing Clinics of North America, 1992Oxygen-free radical production and reperfusion injury are complex mechanisms. New and improved methods for maximizing the benefits of reperfusion while minimizing reperfusion injury are on the horizon in the 1990s. Critical care nurses play a crucial role in the assessment, planning, and intervention of patients experiencing the deleterious effects of ...
V J, Coombs, L, Black, S N, Townsend
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Cellular recruitment in myocardial ischaemia/reperfusion injury
European Journal of Clinical Investigation, 2016AbstractBackgroundMyocardial infarction (MI) is strictly linked to atherosclerosis. Beyond the mechanical narrowing of coronary vessels lumen, during MI a great burden of inflammation is carried out. One of the crucial events is represented by the ischaemia/reperfusion injury, a complex event involving inflammatory cells (such as neutrophils, platelets,
BONAVENTURA, ALDO +2 more
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Free radicals and myocardial reperfusion injury
British Medical Bulletin, 1993Ischaemic myocardial tissue will, inevitably, necrose if blood flow is not restored. Whilst reperfusion is always beneficial in terms of potential recovery of heart muscle, reperfusion in itself is believed to bring about cellular injury. While the causes of this 'reperfusion injury' are apparently multifactorial, there is now an increasing body of ...
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