BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury
Frontiers in Physiology, 2019 The actions of BDNF (Brain-derived Neurotrophic Factor) in regulating neuronal development and modulating synaptic activity have been extensively studied and well established.
Pouneh Kermani +2 more
doaj +1 more source
Mathematical modeling of active contraction of the human cardiac myocyte: A review
Heliyon, 2023 Background and objective: In this present research paper, a mathematical model has been developed to study myocyte contraction in the human cardiac muscle, using the Land model.
Fisal Asiri +6 more
doaj +1 more source
Aetiology of sudden cardiac death in sport: a histopathologist's perspective. [PDF]
, 2012 In the UK, when a young person dies suddenly, the coroner is responsible for establishing the cause of death. They will ask a consultant pathologist to carry out an autopsy in order to ascertain when, where and how that person died.
Sheppard, MN
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Heliyon, 2023 Aims: Upregulation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) contributes to the pathogenesis of cardiovascular disease, including hypertension.
Xiaoqiang Sun +7 more
doaj +1 more source
Dystrophic cardiomyopathy: role of the cardiac myofilaments
Frontiers in Physiology, 2023 Dystrophic cardiomyopathy arises from mutations in the dystrophin gene. Dystrophin forms part of the dystrophin glycoprotein complex and is postulated to act as a membrane stabilizer, protecting the sarcolemma from contraction-induced damage.
Thomas G. George +4 more
doaj +1 more source
Decreased myocardial injury and improved contractility after administration of a peptide derived against the alpha-interacting domain of the L-type calcium channel. [PDF]
, 2014 BackgroundMyocardial infarction remains the leading cause of morbidity and mortality associated with coronary artery disease. The L-type calcium channel (IC a-L) is critical to excitation and contraction.
Hool, Livia C +3 more
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Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk. [PDF]
, 2016 Population-based computational approaches have been developed in recent years and helped to gain insight into arrhythmia mechanisms, and intra- and inter-patient variability (e.g., in drug responses). Here, we illustrate the use of multivariable logistic
Grandi, Eleonora, Morotti, Stefano
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Cellular Physiology and Biochemistry, 2017 Background/Aims: The alterations in myocyte autophagy after myocardial infarction (MI) and the underlying mechanisms have not been fully understood. In this study, we investigated the temporal changes of myocyte autophagy in the remote non-infarcted ...
Rui-Fang Chi +9 more
doaj +1 more source
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis [PDF]
, 2019 Aims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying electrophysiological alterations hampers ...
Benítez Iglesias, Raúl +9 more
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Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? [PDF]
, 2017 Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological ...
Agra +164 more
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