Results 11 to 20 of about 124,243 (355)

Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

open access: yesNature Communications, 2018
How the cardiac myocyte epigenome is rearranged during development, postnatal maturation and disease is not well understood. Here, the authors investigate the human cardiac myocyte epigenome during development and chronic heart failure and identify ...
Ralf Gilsbach   +2 more
exaly   +2 more sources

Optimization of Mechanosensitive Cross-Talk between Matrix Stiffness and Protein Density: Independent Matrix Properties Regulate Spreading Dynamics of Myocytes

open access: yesCells, 2022
Cells actively sense differences in topology, matrix elasticity and protein composition of the extracellular microenvironment and adapt their function and morphology.
Judith Brock   +3 more
doaj   +1 more source

A method to increase reproducibility in adult ventricular myocyte sizing and flow cytometry: Avoiding cell size bias in single cell preparations. [PDF]

open access: yes, 2017
RATIONALE:Flow cytometry (FCM) of ventricular myocytes (VMs) is an emerging technology in adult cardiac research that is challenged by the wide variety of VM shapes and sizes.
Aminololama-Shakeri, Shadi   +4 more
core   +10 more sources

Calsarcin-2 May Play a Compensatory Role in the Development of Obese Sarcopenia

open access: yesBiomedicines, 2023
Although obese sarcopenia is a major public health problem with increasing prevalence worldwide, the factors that contribute to the development of obese sarcopenia are still obscure.
Yu-Cheng Liang   +7 more
doaj   +1 more source

Changes in Cardiomyocyte Cell Cycle and Hypertrophic Growth During Fetal to Adult in Mammals

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
The failure of adult cardiomyocytes to reproduce themselves to repair an injury results in the development of severe cardiac disability leading to death in many cases.
Sanford P. Bishop   +3 more
doaj   +1 more source

Dexamethasone Treatment Preserves the Structure of Adult Cardiac Explants and Supports Their Long-Term Contractility In Vitro

open access: yesInternational Journal of Translational Medicine, 2023
Normal contractile function of the myocardium is essential for optimal cardiovascular health. Evaluating drug effects on cardiomyocyte function at the cellular level is difficult for long-term studies.
Leonard M. Eisenberg   +4 more
doaj   +1 more source

Cysteamine improves growth and the GH/IGF axis in gilthead sea bream (Sparus aurata): in vivo and in vitro approaches

open access: yesFrontiers in Endocrinology, 2023
Aquaculture is the fastest-growing food production sector and nowadays provides more food than extractive fishing. Studies focused on the understanding of how teleost growth is regulated are essential to improve fish production.
Albert Sánchez-Moya   +10 more
doaj   +1 more source

Anatomical-MRI Correlations in Adults and Children with Arrhythmogenic Right Ventricular Cardiomyopathy

open access: yesDiagnostics, 2021
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare disease in which the right ventricular myocardium is replaced by islands of fibro-adipose tissue. Therefore, ventricular re-entry circuits can occur, predisposing the patient to ventricular
Simona-Sorana Cainap   +9 more
doaj   +1 more source

Oxidative stress impairs myocyte autophagy, resulting in myocyte hypertrophy [PDF]

open access: yesExperimental Physiology, 2018
New Findings What is the central question of this study? Does oxidative stress induce impairment of autophagy that results in myocyte hypertrophy early after pressure overload? What is the main finding and its importance? In cultured myocytes, hydrogen peroxide decreased autophagy and increased hypertrophy, and inhibition of autophagy enhanced myocyte
Jia‐Pu Wang   +9 more
openaire   +2 more sources

Elimination of Mutant mtDNA by an Optimized mpTALEN Restores Differentiation Capacities of Heteroplasmic MELAS-iPSCs

open access: yesMolecular Therapy: Methods & Clinical Development, 2021
Various mitochondrial diseases, including mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), are associated with heteroplasmic mutations in mitochondrial DNA (mtDNA).
Naoki Yahata, Hiroko Boda, Ryuji Hata
doaj   +1 more source

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