Results 21 to 30 of about 124,243 (355)

Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells

Frontiers in Pharmacology, 2023
Background and purpose: While flecainide is now an accepted treatment for arrhythmias associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), its mechanism of action remains controversial.
Emma J. Steer, Zhaokang Yang, Moza M. Al-Owais, Hannah M. Kirton, Edward White, Derek S. Steele   +5 more
doaj   +1 more source

MicroRNAs in Sarcopenia: A Systematic Review

Frontiers in Medicine, 2020
Sarcopenia, which is characterized by the loss of skeletal muscle, has been reported to contribute to development of physical disabilities, various illnesses, and increasing mortality. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit translation
Katsunori Yanai, Shohei Kaneko, Hiroki Ishii, Akinori Aomatsu, Akinori Aomatsu, Kiyonori Ito, Keiji Hirai, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita   +9 more
doaj   +1 more source

Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy [PDF]

, 2003
It is generally believed that increase in adult contractile cardiac mass can be accomplished only by hypertrophy of existing myocytes. Documentation of myocardial regeneration in acute stress has challenged this dogma and led to the proposition that ...
Anversa P., CASTALDO, CLOTILDE, Kajstura J, Leri A, Nadal Ginard B, Quaini E, Quaini F, Tasca G, Torella D, Urbanek K   +9 more
core   +1 more source

KV4.3 Expression Modulates NaV1.5 Sodium Current

Frontiers in Physiology, 2018
In cardiomyocytes, the voltage-gated transient outward potassium current (Ito) is responsible for the phase-1 repolarization of the action potential (AP).
Vincent Portero, Ronald Wilders, Simona Casini, Flavien Charpentier, Arie O. Verkerk, Arie O. Verkerk, Carol Ann Remme   +6 more
doaj   +1 more source

The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis

Skeletal Muscle, 2011
Myogenesis is a complex and tightly regulated process, the end result of which is the formation of a multinucleated myofibre with contractile capability.
Knight James DR, Kothary Rashmi
doaj   +1 more source

Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition [PDF]

, 2008
Inhibition of glycogen synthase kinase 3β (GSK3β) as a consequence of its phosphorylation by protein kinase B/Akt (PKB/Akt) has been implicated in cardiac myocyte hypertrophy in response to endothelin-1 or phenylephrine.
Alsafi, Ali, Clerk, Angela, Cullingford, Timothy E., Fuller, Stephen John, Giraldo Ramirez, Alejandro, Markou, Thomais, Sugden, Peter H., Weiss, Sophie C.   +7 more
core   +1 more source

Active Movement of the Tunic in Halocynthia roretzi

Journal of Biomechanical Science and Engineering, 2010
Halocynthia roretzi, a solitary ascidian, can swell and deflate its solid, leather-like tunic largely, but it is not clear whether the tunic deforms actively.
Yoko KATO
doaj   +1 more source

Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]

, 2015
Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M., Baillie, George S., Corsetti, Veronica, Dodoni, Giuliano, Fields, Laura A., Furlan, Leonardo, Gesellchen, Frank, Graham, Delyth, Hamilton, Graham M., Jiang, He, Krall, Judith, Lefkimmiatis, Konstantinos, Livie, Craig, Mancuso, Luisa, Movsesian, Matthew, Nicklin, Stuart A., Sin, Yuan Yan, Sjaastad, Ivar, Stangherlin, Alessandra, Surdo, Nicoletta C., Szabo-Fresnais, Nicolas, Terrin, Anna, Vandeput, Fabrice, Zaccolo, Manuela, Zoccarato, Anna   +24 more
core   +1 more source

Sex differences in skeletal muscle revealed through fiber type, capillarity, and transcriptomics profiling in mice

Physiological Reports, 2021
Skeletal muscle anatomy and physiology are sexually dimorphic but molecular underpinnings and muscle‐specificity are not well‐established. Variances in metabolic health, fitness level, sedentary behavior, genetics, and age make it difficult to discern ...
Juliana O’Reilly, Kikumi D. Ono‐Moore, Sree V. Chintapalli, Jennifer M. Rutkowsky, Todd Tolentino, K. C. Kent Lloyd, I. Mark Olfert, Sean H. Adams   +7 more
doaj   +1 more source

Intramyocardial Fibroblast Myocyte Communication [PDF]

Circulation Research, 2010
Abstract : Cardiac fibroblasts are emerging as key components of normal cardiac function, as well as the response to stressors and injury. These most numerous cells of the heart interact with myocytes via paracrine mechanisms, alterations in ...
Rahul, Kakkar, Richard T, Lee
openaire   +2 more sources