Ghrelin Stimulates Myocyte Development [PDF]
Cellular Physiology and Biochemistry, 2007 Ghrelin, a gastric peptide hormone, may regulate mesenchymal cell development. Here we show that ghrelin promotes myogenesis in vitro in the mouse myoblast cell line C2C12 cells. Cells expressing ghrelin demonstrated a significant increase in the differentiation of premyocytes into myocytes.
Weizhen, Zhang +2 more
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Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart [PDF]
Journal of Visualized Experiments, 2020 The isolation and culturing of cardiac myocytes from mice has been essential for furthering the understanding of cardiac physiology and pathophysiology. While isolating myocytes from neonatal mouse hearts is relatively straightforward, myocytes from the adult murine heart are preferred.
Erik A, Blackwood +4 more
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Global intracoronary infusion of allogeneic cardiosphere-derived cells improves ventricular function and stimulates endogenous myocyte regeneration throughout the heart in swine with hibernating myocardium. [PDF]
PLoS ONE, 2014 Cardiosphere-derived cells (CDCs) improve ventricular function and reduce fibrotic volume when administered via an infarct-related artery using the "stop-flow" technique.
Gen Suzuki +6 more
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Which diagnostic tests are most useful in a chest pain unit protocol? [PDF]
, 2005 Background The chest pain unit (CPU) provides rapid diagnostic assessment for patients with acute, undifferentiated chest pain, using a combination of electrocardiographic (ECG) recording, biochemical markers and provocative cardiac testing.
Angelini, K. +4 more
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Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes. [PDF]
, 2020 Excitation-contraction (EC) coupling is the coordinated process by which an action potential triggers cardiac myocyte contraction. EC coupling is initiated in dyads where the junctional sarcoplasmic reticulum (jSR) is in tight proximity to the sarcolemma
de la Mata, Ana +5 more
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Gender differences in cardiac left ventricular mass and function: clinical and experimental observations [PDF]
, 2014 Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats.
Aiello, Ernesto Alejandro +5 more
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Micro-Managing Myocyte Mitosis [PDF]
Circulation Research, 2011 See related article, pages 670–679 In the adult mammalian heart, cardiac myocyte renewal is rare1,2 and insufficient to restore normal pump function after significant myocardial damage. Recent studies, however, suggest that zebrafish hearts3–5 and neonatal mouse hearts6 can regenerate after injury through enhanced cardiac myocyte proliferation.
Deqiang, Li, Jonathan A, Epstein
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Nucleus, 2019 The double membrane nuclear envelope (NE), which is contiguous with the ER, contains nuclear pore complexes (NPCs) – the channels for nucleocytoplasmic transport, and the nuclear lamina (NL) – a scaffold for NE and chromatin organization.
Li-Chun Cheng +8 more
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Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size [PDF]
, 2016 Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids ...
Abendschein, Dana +12 more
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Cells, 2021 Atrial fibrillation is very common among the elderly and/or obese. While myocardial fibrosis is associated with atrial fibrillation, the exact mechanisms within atrial myocytes and surrounding non-myocytes are not fully understood.
Anirudh Krishnan +7 more
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