KV4.3 Expression Modulates NaV1.5 Sodium Current
Frontiers in Physiology, 2018 In cardiomyocytes, the voltage-gated transient outward potassium current (Ito) is responsible for the phase-1 repolarization of the action potential (AP).
Vincent Portero +6 more
doaj +1 more source
The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis
Skeletal Muscle, 2011 Myogenesis is a complex and tightly regulated process, the end result of which is the formation of a multinucleated myofibre with contractile capability.
Knight James DR, Kothary Rashmi
doaj +1 more source
Myogenin promotes myocyte fusion to balance fibre number and size
Nature Communications, 2018 Each skeletal muscle acquires its unique size before birth, when terminally differentiating myocytes fuse to form a defined number of multinucleated myofibres.
M. Ganassi +5 more
semanticscholar +1 more source
Active Movement of the Tunic in Halocynthia roretzi
Journal of Biomechanical Science and Engineering, 2010 Halocynthia roretzi, a solitary ascidian, can swell and deflate its solid, leather-like tunic largely, but it is not clear whether the tunic deforms actively.
Yoko KATO
doaj +1 more source
Microtubules provide a viscoelastic resistance to myocyte motion
bioRxiv, 2018 Background Microtubules (MT) buckle and bear load during myocyte contraction, a behavior enhanced by post-translational detyrosination. This buckling suggests a spring-like resistance against myocyte shortening, which could store energy and aid myocyte ...
M. Caporizzo +5 more
semanticscholar +1 more source
Oxidative stress impairs myocyte autophagy, resulting in myocyte hypertrophy [PDF]
Experimental Physiology, 2018 New Findings What is the central question of this study? Does oxidative stress induce impairment of autophagy that results in myocyte hypertrophy early after pressure overload? What is the main finding and its importance? In cultured myocytes, hydrogen peroxide decreased autophagy and increased hypertrophy, and inhibition of autophagy enhanced myocyte
Jia‐Pu Wang +9 more
openaire +3 more sources
Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition [PDF]
, 2008 Inhibition of glycogen synthase kinase 3β (GSK3β) as a consequence of its phosphorylation by protein kinase B/Akt (PKB/Akt) has been implicated in cardiac myocyte hypertrophy in response to endothelin-1 or phenylephrine.
Alsafi, Ali +7 more
core +1 more source
Global intracoronary infusion of allogeneic cardiosphere-derived cells improves ventricular function and stimulates endogenous myocyte regeneration throughout the heart in swine with hibernating myocardium. [PDF]
PLoS ONE, 2014 Cardiosphere-derived cells (CDCs) improve ventricular function and reduce fibrotic volume when administered via an infarct-related artery using the "stop-flow" technique.
Gen Suzuki +6 more
doaj +1 more source
Gender differences in cardiac left ventricular mass and function: clinical and experimental observations [PDF]
, 2014 Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats.
Aiello, Ernesto Alejandro +5 more
core +2 more sources
Caveolae and the cardiac myocyte [PDF]
Current Opinion in Physiology, 2018 Caveolae, invaginated lipid rafts, orchestrate signalling in the cardiac myocyte. Here we highlight advances in the field which are relevant to the role of caveolae in these cells. Recent analysis of the molecular organisation and structure of the coat complex, which lines the internal surface of caveolae, suggest a stable inner caveolin layer covered ...
Norman, R, Fuller, W, Calaghan, S
openaire +3 more sources