Results 1 to 10 of about 285,913 (271)

Kv2.1 channels play opposing roles in regulating membrane potential, Ca2+ channel function, and myogenic tone in arterial smooth muscle. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
The accepted role of the protein Kv2.1 in arterial smooth muscle cells is to form K+ channels in the sarcolemma. Opening of Kv2.1 channels causes membrane hyperpolarization, which decreases the activity of L-type CaV1.2 channels, lowering intracellular ...
Guarina, Laura, Klug, Nicholas R, Matsumoto, Collin, McKinnon, David, O'Dwyer, Samantha C, Palacio, Stephanie, Rosati, Barbara, Santana, L Fernando, Tajada, Sendoa, Trimmer, James S   +9 more
core   +4 more sources

The Role of Mechanotransduction on Vascular Smooth Muscle Myocytes Cytoskeleton and Contractile Function [PDF]

The Anatomical Record, 2014
ABSTRACTSmooth muscle (SM) exhibits a highly organized structural hierarchy that extends over multiple spatial scales to perform a wide range of functions at the cellular, tissue, and organ levels. Early efforts primarily focused on understanding vascular SM (VSM) function through biochemical signaling.
George J.C. Ye, Kevin Kit Parker, Alexander P. Nesmith   +2 more
openaire   +4 more sources

Proliferative role of Kv11 channels in murine arteries [PDF]

Frontiers in Physiology, 2017
K+ channels encoded by the ether-a-go-go related gene (ERG1 or KCNH2) are important determinants of the cardiac action potential. Expression of both cardiac isoforms (ERG1 and ERG1b) were identified in murine portal vein and distinctive voltage-gated K ...
Abbott, Akbarali, Arcangeli, Babcock, Casis, Cidad, Curran, Doggrell, Farrelly, Greenwood, Guasti, Hansen, Haushalter, Iannotti, Larsen, Larsen, Lees-Miller, London, Mazhari, McCrossan, Mewe, Mulvany, Ohya, Pardo, Parr, Phartiyal, Pond, Rajamani, Sale, Shi, Smith, Spector, Vandenberg, Yeung, Yeung, Zhou   +35 more
core   +5 more sources

Smooth Muscle Cells, But Not Myocytes, of Host Origin in Transplanted Human Hearts [PDF]

Circulation, 2002
Background — There is increasing evidence to support a role for stem cells in the regeneration and repair of the human cardiovascular system.
Jonathan A. Epstein, Navneet Narula, Min Min Lu, Ruchira Glaser   +3 more
openaire   +4 more sources

Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1999
We tested the hypothesis that prolonged serum deprivation would allow a subset of cultured airway myocytes to reacquire the abundant contractile protein content, marked shortening capacity, and elongated morphology characteristic of contractile cells within intact tissue. Passage 1 or 2 canine tracheal smooth muscle (SM) cells were grown to confluence,
Richard W. Mitchell, Mark E. Wylam, Julian Solway, Andrew J. Halayko, Blanca Camoretti-Mercado, Joaquim Edson Vieira, Marc B. Hershenson, Sean M. Forsythe   +7 more
openaire   +4 more sources

cGMP signals in smooth muscle cells and cardiac myocytes [PDF]

BMC Pharmacology, 2011
Background cGMP plays an important role in the cardiovascular system and is involved in smooth muscle relaxation and inhibition of platelet aggregation. cGMP concentrations inside cells are determined by an interplay of cGMP synthesis through natriuretic peptide or NO receptor guanylyl cyclases on the one hand and cGMP-degrading phosphodiesterases on ...
Michael Russwurm, Christian Krawutschke, Doris Koesling   +2 more
openaire   +2 more sources

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]

, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP, Baudel, MASM-A, Large, WA, Shi, J   +3 more
core   +1 more source

Mitochondrial Modulation Of Spontaneous Ca2+ Oscillations In Portal Vein Smooth Muscle Myocytes [PDF]

Biophysical Journal, 2009
Transient increases in cytosolic Ca2+ concentration ([Ca2+]c) regulate many smooth muscle activities including contraction, transcription, growth and apoptosis. The onset of some processes involve sarcoplasmic reticulum Ca2+ release triggered by either inositol 1,4,5-trisphosphate (InsP3) or occurring spontaneously. Mitochondrial Ca2+ uptake influences
Marnie L. Olson, John G. McCarron, Nicolaos Avlonitis, Susan Chalmers, Megan N. Stanton-Humphreys, Stuart J. Conway   +5 more
openaire   +2 more sources

Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. [PDF]

, 2005
BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M, Coetzee, WA, Dhar Chowdhury, P, Giblin, JP, Han, S, Lanning, J, Lopez, G, Morrissey, A, Nakamura, TY, Parachuru, L, Rosner, E, Tinker, A, Tong, X, Yoshida, H   +13 more
core   +3 more sources

Distribution of phenotypically disparate myocyte subpopulations in airway smooth muscle

Canadian Journal of Physiology and Pharmacology, 2005
Phenotype and functional heterogeneity of airway smooth muscle (ASM) cells in vitro is well known, but there is limited understanding of these features in vivo. We tested whether ASM is composed of myocyte subsets differing in contractile phenotype marker expression. We used flow cytometry to compare smooth muscle myosin heavy chain (smMHC) and smooth
Halayko, AJ, Stelmack, GL, Yamasaki, A, McNeill, K, Unruh, H, Rector, E   +5 more
openaire   +4 more sources