Ca2+ microdomain-based excitation-transcription coupling in cardiac myocytes and vascular smooth muscle cells [PDF]
Inflammation and RegenerationCa2+ signals play a crucial role in maintaining cardiovascular homeostasis, including regulation of the heartbeat, blood pressure, and adaptation to changes in the external environment.
Tsukasa Koide +5 more
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Proliferative Role of Kv11 Channels in Murine Arteries [PDF]
Frontiers in Physiology, 2017 K+ channels encoded by the ether-a-go-go related gene (ERG1 or KCNH2) are important determinants of the cardiac action potential. Expression of both cardiac isoforms (ERG1a and ERG1b) were identified in murine portal vein and distinctive voltage-gated K+
Vincenzo Barrese +7 more
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Kv2.1 channels play opposing roles in regulating membrane potential, Ca2+ channel function, and myogenic tone in arterial smooth muscle. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 The accepted role of the protein Kv2.1 in arterial smooth muscle cells is to form K+ channels in the sarcolemma. Opening of Kv2.1 channels causes membrane hyperpolarization, which decreases the activity of L-type CaV1.2 channels, lowering intracellular ...
Guarina, Laura +9 more
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The Role of Mechanotransduction on Vascular Smooth Muscle Myocytes Cytoskeleton and Contractile Function [PDF]
The Anatomical Record, 2014 ABSTRACTSmooth muscle (SM) exhibits a highly organized structural hierarchy that extends over multiple spatial scales to perform a wide range of functions at the cellular, tissue, and organ levels. Early efforts primarily focused on understanding vascular SM (VSM) function through biochemical signaling.
George J.C. Ye +2 more
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Smooth Muscle Cells, But Not Myocytes, of Host Origin in Transplanted Human Hearts [PDF]
Circulation, 2002 Background — There is increasing evidence to support a role for stem cells in the regeneration and repair of the human cardiovascular system.
Jonathan A. Epstein +3 more
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Defining cardiac cell populations and relative cellular composition of the early fetal human heart
PLoS ONE, 2022 While the adult human heart is primarily composed of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells, the cellular composition during early development remains largely unknown.
Jennifer M. Dewing +3 more
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cGMP signals in smooth muscle cells and cardiac myocytes [PDF]
BMC Pharmacology, 2011 Background cGMP plays an important role in the cardiovascular system and is involved in smooth muscle relaxation and inhibition of platelet aggregation. cGMP concentrations inside cells are determined by an interplay of cGMP synthesis through natriuretic peptide or NO receptor guanylyl cyclases on the one hand and cGMP-degrading phosphodiesterases on ...
Michael Russwurm +2 more
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Frontiers in Pharmacology, 2021 Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus (DM). Our previous study suggested that the expression of the long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is closely related to ...
Yanjuan Wang +7 more
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Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle. [PDF]
PLoS ONE, 2008 Hollow smooth muscle organs such as the bladder undergo significant changes in wall tension associated with filling and distension, with attendant changes in muscle tone. Our previous study indicated that stretch induces Ca(2+) release occurs in the form
Bin Wei +9 more
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Biochemical and molecular-physiological aspects of the nitric oxide action in the utera [PDF]
The Ukrainian Biochemical Journal, 2021 The sources of the nitric oxide (NO) formation in the uterus and the dynamics of changes in its content in different periods of organ functioning in human and animals are analyzed.
H. V. Danylovych, Yu. V. Danylovych
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