Results 41 to 50 of about 62,427 (259)

Effects of polyamines on the muscarinic receptor‐operated cation current in guinea‐pig ileal smooth muscle myocytes [PDF]

British Journal of Pharmacology, 2004
The effects of extracellular and intracellular polyamines (PAs), spermine and putrescine, on the cation current (mICAT) evoked either by activating muscarinic receptors with carbachol or by intracellularly applied GTPγS (in the absence of carbachol) were studied using patch‐clamp recording techniques in single guinea‐pig ileal myocytes. Extracellular
Tsvilovskyy, V.V., Zholos, Alexander, Bolton, T.B.   +2 more
openaire   +2 more sources

Myocardial repair with long-term and low-dose administration of a nitric oxide synthesis inhibitor. Myofibroblasts, type III collagen and fibronectin

Arquivos Brasileiros de Cardiologia, 1999
OBJECTIVE: To study the healing process of the myocardium in hypertensive rats undergoing inhibition of nitric oxide synthesis. METHODS: Two groups of animals were studied: one received L-NAME, 12mg/kg/day, and the other was a control group. The presence
Mônica Gomes Pessanha, Myriam Dumas Hahn, Carlos Alberto Mandarim-de-Lacerda   +2 more
doaj   +1 more source

Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]

, 2006
KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence ...
AM Evans, AM Gurney, BC Schroeder, C Lerche, DA Brown, H-S Wang, HL Pieniaszek, HS Wang, J Robbins, JA Lamas, JP Savineau, K Chootip, LH Clapp, LH Clapp, ME Schnee, N Tinel, PJ Barnes, S Ohya, S Teng, SY Yeung, T Inoue, TJ Jentsch, VJ Nickolson, W-P Yang   +23 more
core   +3 more sources

Heteromeric Channels Formed From Alternating Kv7.4 and Kv7.5 α-Subunits Display Biophysical, Regulatory, and Pharmacological Characteristics of Smooth Muscle M-Currents

Frontiers in Physiology, 2020
Smooth muscle cells of the vasculature, viscera, and lungs generally express multiple α-subunits of the Kv7 voltage-gated potassium channel family, with increasing evidence that both Kv7.4 and Kv7.5 can conduct “M-currents” that are functionally ...
Lyubov I. Brueggemann, Leanne L. Cribbs, Kenneth L. Byron   +2 more
doaj   +1 more source

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling

Cell Reports, 2015
The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels.
Kevin Retailleau, Fabrice Duprat, Malika Arhatte, Sanjeev Sumant Ranade, Rémi Peyronnet, Joana Raquel Martins, Martine Jodar, Céline Moro, Stefan Offermanns, Yuanyi Feng, Sophie Demolombe, Amanda Patel, Eric Honoré   +12 more
doaj   +1 more source

Calix[4]arene C-99 inhibits myosin ATPase activity and changes the organization of contractile filaments of myometrium [PDF]

The Ukrainian Biochemical Journal, 2015
Calix[4]arenes are cup-like macrocyclic (polyphenolic) compounds, they are regarded as promising molecular “platforms” for the design of new physiologically active compounds.
R. D. Labyntseva,, A. A. Bevza, A. О. Lul’ko, S. О. Cherenok, V. I. Kalchenko, S. О. Kosterin   +5 more
doaj   +1 more source

Depletion of Ca2+ from the sarcoplasmic reticulum of cardiac muscle prompts phosphorylation of phospholamban to stimulate store refilling [PDF]

, 1998
Nonmuscle cells have almost ubiquitously evolved a mechanism to detect and prevent Ca(2+) store depletionstore operated calcium entry. No such mechanism has, as yet, been reported in cardiac myocytes.
Bhogal, M.S., Colyer, J.
core   +2 more sources

Amyloid β alters vascular Ca_V1.2 channel spatiotemporal properties. [PDF]

J Physiol
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Taylor JL, Baudel MM, Pereira da Silva E, Hell JW, Nieves-Cintron M, Navedo MF.   +5 more
europepmc   +2 more sources

Synthesis and Biological Characterization of a New Norbormide Derived Bodipy FL-Conjugated Fluorescent Probe for Cell Imaging [PDF]

, 2018
Background: Norbormide (NRB) is a selective rat toxicant endowed with vasoconstrictor activity confined to the rat peripheral arteries. In a recent work we used a fluorescent derivative of NRB (NRB-AF12), obtained by coupling the NBD fluorophore to the ...
Bova, Sergio, Brimble, Margaret A., Ceolotto, Giulio, D'AMORE, CLAUDIO, Forgiarini, Alessia, Hopkins, Brian, Jay-Smith, Morgan, Orso, Genny, Rennison, David, Ribaudo, Giovanni   +9 more
core   +3 more sources

Transgenic Overexpression of β2-Adrenergic Receptors in Airway Smooth Muscle Alters Myocyte Function and Ablates Bronchial Hyperreactivity [PDF]

Journal of Biological Chemistry, 1999
beta(2)-Adrenergic receptors (beta(2)AR) act to relax airway smooth muscle and can serve to counteract hyperresponsiveness, although the effect may not be ablative even in the presence of exogenous agonist. Within this signaling cascade that ultimately transduces smooth muscle relaxation, a significant "spare receptor" pool has been hypothesized to be ...
D W, McGraw, S L, Forbes, L A, Kramer, D P, Witte, C N, Fortner, R J, Paul, S B, Liggett   +6 more
openaire   +2 more sources