Frontiers in Physiology, 2020 Smooth muscle cells of the vasculature, viscera, and lungs generally express multiple α-subunits of the Kv7 voltage-gated potassium channel family, with increasing evidence that both Kv7.4 and Kv7.5 can conduct “M-currents” that are functionally ...
Lyubov I. Brueggemann +2 more
doaj +1 more source
Kv7 and Kv11 channels in myometrial regulation. [PDF]
, 2013 Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Iain A. Greenwood +3 more
core +2 more sources
Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling
Cell Reports, 2015 The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels.
Kevin Retailleau +12 more
doaj +1 more source
Морфологія, 2020 Background. Significant prevalence and the possibility of transformation into organic pathology determine the relevance of functional disorders of the gallbladder and sphincter of Oddi in children.
A. E. Abaturov +5 more
doaj +1 more source
Calix[4]arene C-99 inhibits myosin ATPase activity and changes the organization of contractile filaments of myometrium [PDF]
The Ukrainian Biochemical Journal, 2015 Calix[4]arenes are cup-like macrocyclic (polyphenolic) compounds, they are regarded as promising molecular “platforms” for the design of new physiologically active compounds.
R. D. Labyntseva, +5 more
doaj +1 more source
Effects of polyamines on the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle myocytes [PDF]
British Journal of Pharmacology, 2004 The effects of extracellular and intracellular polyamines (PAs), spermine and putrescine, on the cation current (mI(CAT)) evoked either by activating muscarinic receptors with carbachol or by intracellularly applied GTPgammaS (in the absence of carbachol) were studied using patch-clamp recording techniques in single guinea-pig ileal myocytes ...
Tsvilovskyy, V.V. +2 more
openaire +3 more sources
Muller Muscle of the Upper Eyelid: Histopathological Features of Congenital and Acquired Ptosis
Oftalʹmologiâ, 2020 Purpose: to study the histological features of the Muller muscle of the upper eyelid in patients with congenital and acquired ptosis to understand the mechanism of ptosis. Material and methods.
M. G. Kataev +5 more
doaj +1 more source
Suppression of cardiomyocyte functions by β-CTX isolated from the Thai king cobra (Ophiophagus hannah) venom via an alternative method [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: Beta-cardiotoxin (β-CTX), the three-finger toxin isolated from king cobra (Ophiophagus hannah) venom, possesses β-blocker activity as indicated by its negative chronotropy and its binding property to both β-1 and β-2 adrenergic receptors and ...
Tuchakorn Lertwanakarn +8 more
doaj +1 more source
Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways [PDF]
, 2018 The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease.
Hollenhorst, M. I. +7 more
core +2 more sources
Evidence For Phosphorylation-Dependent Modulation of BK Channel Activity in Vascular Smooth Muscle (VSM) Myocytes and Resistance Arteries [PDF]
Biophysical Journal, 2016 VSM excitability is regulated by large conductance, calcium-activated K+ (BK) channels. We have previously reported that type I cGMP-dependent protein kinase (cGKI) phosphorylates the BK channel at key serine residues, leading to augmented BK current magnitude. Here, we investigate the cellular mechanisms regulating the temporal pattern (i.e. onset and
Barry D. Kyle +2 more
openaire +2 more sources