Results 41 to 50 of about 285,913 (271)

Myocardial repair with long-term and low-dose administration of a nitric oxide synthesis inhibitor. Myofibroblasts, type III collagen and fibronectin

Arquivos Brasileiros de Cardiologia, 1999
OBJECTIVE: To study the healing process of the myocardium in hypertensive rats undergoing inhibition of nitric oxide synthesis. METHODS: Two groups of animals were studied: one received L-NAME, 12mg/kg/day, and the other was a control group. The presence
Mônica Gomes Pessanha, Myriam Dumas Hahn, Carlos Alberto Mandarim-de-Lacerda   +2 more
doaj   +1 more source

Heteromeric Channels Formed From Alternating Kv7.4 and Kv7.5 α-Subunits Display Biophysical, Regulatory, and Pharmacological Characteristics of Smooth Muscle M-Currents

Frontiers in Physiology, 2020
Smooth muscle cells of the vasculature, viscera, and lungs generally express multiple α-subunits of the Kv7 voltage-gated potassium channel family, with increasing evidence that both Kv7.4 and Kv7.5 can conduct “M-currents” that are functionally ...
Lyubov I. Brueggemann, Leanne L. Cribbs, Kenneth L. Byron   +2 more
doaj   +1 more source

Na+-leak channel, non-selective (NALCN) regulates myometrial excitability and facilitates successful parturition [PDF]

, 2018
Background/Aims: Uterine contractility is controlled by electrical signals generated by myometrial smooth muscle cells. Because aberrant electrical signaling may cause inefficient uterine contractions and poor reproductive outcomes, there is great ...
Amazu, Chinwendu, Bok, Rachael, England, Sarah K., Hurt, K. Joseph, Ma, Xiaofeng, Reinl, Erin L., Wang, Yong, Wu, Wenjie, Zhao, Peinan   +8 more
core   +3 more sources

Effects of polyamines on the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle myocytes [PDF]

British Journal of Pharmacology, 2004
The effects of extracellular and intracellular polyamines (PAs), spermine and putrescine, on the cation current (mI(CAT)) evoked either by activating muscarinic receptors with carbachol or by intracellularly applied GTPgammaS (in the absence of carbachol) were studied using patch-clamp recording techniques in single guinea-pig ileal myocytes ...
Tsvilovskyy, V.V., Zholos, Alexander, Bolton, T.B.   +2 more
openaire   +3 more sources

Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines [PDF]

, 2008
Krüppel-like transcription factors (Klfs) modulate fundamental cell processes. Cardiac myocytes are terminally-differentiated, but hypertrophy in response to stimuli such as endothelin-1. H2O2 or cytokines promote myocyte apoptosis. Microarray studies of
Ahmad, Andrew K. Marshall, Angela Clerk, Atkins, Bieker, Bilanges, Bogoyevitch, Boon, Chen, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Clerk, Cook, Cullingford, Dang, Davies, Dorn, El Li Tham, Favata, Feinberg, Fisch, Ghaleb, Haldar, Hamik, Harrison, Inuzuka, Iwaki, Kaczynski, Kawai-Kowase, Kemp, Kennedy, Kojima, Kyriakis, Lavallée, Leung, Liu, Lomberk, Markou, Matthew J. Butler, Mody, Moriguchi, Ornatsky, Peter H. Sugden, Pham, Pham, Scohy, Sohn, Sugden, Sun, Suske, Suzuki, Timothy E. Cullingford, Uchida, van Thienen, van Vliet, Wani, Yang   +61 more
core   +2 more sources

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling

Cell Reports, 2015
The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels.
Kevin Retailleau, Fabrice Duprat, Malika Arhatte, Sanjeev Sumant Ranade, Rémi Peyronnet, Joana Raquel Martins, Martine Jodar, Céline Moro, Stefan Offermanns, Yuanyi Feng, Sophie Demolombe, Amanda Patel, Eric Honoré   +12 more
doaj   +1 more source

Morphological evaluation of the effects of ursodeoxycholic acid on muscular layer of the gallbladder wall of the mice

Морфологія, 2020
Background. Significant prevalence and the possibility of transformation into organic pathology determine the relevance of functional disorders of the gallbladder and sphincter of Oddi in children.
A. E. Abaturov, V. L. Babуch, N. S. Bondarenko, O. O. Bondarenko, A. E. Lievykh, I. V. Tverdokhlib   +5 more
doaj   +1 more source

Calix[4]arene C-99 inhibits myosin ATPase activity and changes the organization of contractile filaments of myometrium [PDF]

The Ukrainian Biochemical Journal, 2015
Calix[4]arenes are cup-like macrocyclic (polyphenolic) compounds, they are regarded as promising molecular “platforms” for the design of new physiologically active compounds.
R. D. Labyntseva,, A. A. Bevza, A. О. Lul’ko, S. О. Cherenok, V. I. Kalchenko, S. О. Kosterin   +5 more
doaj   +1 more source

Kv7 and Kv11 channels in myometrial regulation. [PDF]

, 2013
Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour.
Iain A. Greenwood, Rachel M. Tribe, Selyanko AA, Taggart MJ   +3 more
core   +2 more sources

Myocardial Perfusion Defects in Hypertrophic Cardiomyopathy Mutation Carriers

Journal of the American Heart Association, EarlyView., 2021
Background Impaired myocardial blood flow (MBF) in the absence of epicardial coronary disease is a feature of hypertrophic cardiomyopathy (HCM). Although most evident in hypertrophied or scarred segments, reduced MBF can occur in apparently normal segments.
Rebecca K. Hughes, Claudia Camaioni, João B. Augusto, Kristopher Knott, Ellie Quinn, Gabriella Captur, Andreas Seraphim, George Joy, Petros Syrris, Perry M. Elliott, Saidi Mohiddin, Peter Kellman, Hui Xue, Luis R. Lopes, James C. Moon   +14 more
wiley   +1 more source