Results 81 to 90 of about 285,913 (271)

Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction

Scientific Reports, 2016
A defining feature of asthma is airway hyperresponsiveness (AHR), which underlies the exaggerated bronchoconstriction response of asthmatics. The role of the airway smooth muscle (ASM) in AHR has garnered increasing interest over the years, but how ...
T. Koopmans, Kuldeep Kumawat, A. Halayko, R. Gosens   +3 more
semanticscholar   +1 more source

Capsaicin-Induced Ca2+ Influx and Constriction of the Middle Meningeal Artery [PDF]

, 2014
Research in the past on transient receptor potential cation channel subfamily V member 1 (TRPV1) has been limited to mainly nervous tissue TRPV1 because of the channel’s role in pain perception.
Koide, Masayo, Kotlikoff, Michael I., Manuelyan, Inessa, Shui, Bo, Syed, Arsalan U., Wellman, George C.   +5 more
core   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

Monolithic Biohybrid Flexure Mechanism Actuated by Bioengineered Skeletal Muscle Tissue

Advanced Intelligent Systems, EarlyView.
A scalable, monolithic biohybrid flexure mechanism is presented, integrating engineered skeletal muscle tissue with a soft, biocompatible, hollow silicone cylinder featuring dual pillars. Muscle contraction induces bending motion upon electrical stimulation, with performance governed by the structure's flexural rigidity.
Andrea Bartolucci, Judith Fuentes, Daniele Guarnera, Florencia Lezcano, Maria Crespo‐Cuadrado, Lorena Guachi‐Guachi, Francesco Iacoponi, Carlotta Salvatori, Riccardo Collu, Massimo Barbaro, Stefano Lai, Leonardo Ricotti, Samuel Sánchez, Lorenzo Vannozzi   +13 more
wiley   +1 more source

Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes

International Journal of Endocrinology, 2020
Introduction. Androgen signaling comprises nongenomic and genomic pathways. Nongenomic actions are not related to the binding of the androgen receptor (AR) and occur rapidly. The genomic effects implicate the binding to a cytosolic AR, leading to protein
Abril Carbajal-García, Jorge Reyes-García, Luis M. Montaño   +2 more
doaj   +1 more source

Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle

Journal of Physiology, 2016
Age is proposed to be associated with altered structure and function of mitochondria; however, in fully‐differentiated cells, determining the structure of more than a few mitochondria at a time is challenging.
S. Chalmers, C. Saunter, J. Girkin, J. McCarron   +3 more
semanticscholar   +1 more source

The lack of the Celf2a splicing factor converts a Duchenne genotype into a Becker phenotype [PDF]

, 2016
Substitutions, deletions and duplications in the dystrophin gene lead to either the severe Duchenne muscular dystrophy (DMD) or mild Becker muscular dystrophy depending on whether out-of-frame or in-frame transcripts are produced.
BOZZONI, Irene, Briganti, F, LEGNINI, IVANO, MARTONE, Julie, MORLANDO, MARIANGELA, Picillo, E, Politano, L, STHANDIER, Olga Elena   +7 more
core   +2 more sources

The contribution of extracellular RNA and its derived biomaterials in disease management

BMEMat, EarlyView.
The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei, Zhangyi Wang, Zixuan Qin, Qianqian Wan, Yutao Li, Franklin R. Tay, Chenyu Wang, Tong Zhang, Lina Niu   +8 more
wiley   +1 more source

Paracrine Effects of FGF23 on the Heart

Frontiers in Endocrinology, 2018
Fibroblast growth factor (FGF) 23 is a phosphaturic hormone primarily secreted by osteocytes to maintain phosphate and mineral homeostasis. In patients with and without chronic kidney disease, enhanced circulating FGF23 levels associate with pathologic ...
Maren Leifheit-Nestler, Dieter Haffner
doaj   +1 more source

Rab25 influences functional Cav1.2 channel surface expression in arterial smooth muscle cells.

American Journal of Physiology - Cell Physiology, 2016
Plasma membrane-localized CaV1.2 channels are the primary calcium (Ca(2+)) influx pathway in arterial smooth muscle cells (myocytes). CaV1.2 channels regulate several cellular functions, including contractility and gene expression, but the trafficking ...
John P A Bannister, Simon Bulley, M. Leo, Michael W. Kidd, J. Jaggar   +4 more
semanticscholar   +1 more source