Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]
, 2019 Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski +48 more
core +2 more sources
Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men. [PDF]
Adv Sci (Weinh)In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Højfeldt G +14 more
europepmc +2 more sources
Herculin, a Fourth Member of the MyoD Family of Myogenic Regulatory Genes [PDF]
, 1990 We have identified and cloned herculin, a fourth mouse muscle regulatory gene. Comparison of its DNA and deduced amino acid sequences with those of the three known myogenic genes (MyoD, myogenin, and Myf-5) reveals scattered short spans with similarity ...
Miner, Jeffrey H., Wold, Barbara J.
core +1 more source
Evolutionary Conservation of MyoD Function and Differential Utilization of E Proteins
Developmental Biology, 1999 The formation of striated muscle in both vertebrates and invertebrates involves the activity of the MyoD family of basic-helix-loop-helix (bHLH) transcription factors. The high degree of evolutionary conservation of MyoD-related proteins, both in the sequence of their bHLH domains and in their general developmental expression patterns, suggests that ...
Zhang, Jian-Min +4 more
openaire +2 more sources
Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation [PDF]
Development, 2007 The basic helix-loop-helix (bHLH) transcription factor Myod directly regulates gene expression throughout the program of skeletal muscle differentiation. It is not known how a Myod-driven myogenic program is modulated to achieve muscle fiber-type-specific gene expression.
Lisa, Maves +6 more
openaire +2 more sources
The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. [PDF]
, 2019 Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation.
Cunningham, Thomas J +9 more
core +3 more sources
Interaction of MyoD Family Proteins with Enhancers of Acetylcholine Receptor Subunit Genes in Vivo [PDF]
Journal of Biological Chemistry, 2000 The myogenic determination factors (MDFs) are transcriptional activators that target E boxes in many muscle-specific promoters, including those of the genes coding for the subunits of the acetylcholine receptor. It is not known, however, if in vivo a given E box in a transcriptionally active gene is occupied, either uniquely by one MDF or randomly by ...
S, Liu +5 more
openaire +2 more sources
MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB
Cell Reports, 2016 MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle metabolism has not been explored. In a genome-wide ChIP-seq analysis of skeletal muscle cells,
Jonathan Shintaku +9 more
doaj +1 more source
Journal of Ginseng Research, 2020 Background: As a process of aging, skeletal muscle mass and function gradually decrease. It is reported that ginsenoside Rb1 and Rb2 play a role as AMP-activated protein kinase activator, resulting in regulating glucose homeostasis, and Rb1 reduces ...
Ga-Yeon Go +9 more
doaj +1 more source
Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells [PDF]
Genes & Development, 2019 The balance between proliferation and differentiation of muscle stem cells is tightly controlled, ensuring the maintenance of a cellular pool needed for muscle growth and repair. We demonstrate here that the transcriptional regulator Hes1 controls the balance between proliferation and differentiation of activated muscle stem cells in both developing ...
Lahmann, Ines +16 more
openaire +6 more sources