Results 31 to 40 of about 19,949 (187)

Characterization of Pectoralis Major Muscle Satellite Cell Population Heterogeneity, Macrophage Density, and Collagen Infiltration in Broiler Chickens Affected by Wooden Breast

Frontiers in Physiology, 2020
Muscle satellite cells (MSCs) are myogenic stem cells that play a critical role in post-hatch skeletal muscle growth and regeneration. Activation of regeneration pathways to repair muscle fiber damage requires both the proliferation and differentiation ...
Tamara Z. Ferreira, Liris Kindlein, Joshua J. Flees, Lauren K. Shortnacy, Sergio L. Vieira, Vladimir P. Nascimento, Kathryn J. Meloche, Jessica D. Starkey   +7 more
doaj   +1 more source

MYOD induced lnc-MEG3 promotes porcine satellite cell differentiation via interacting with DLST

Epigenetics, 2023
Long non-coding RNAs (lncRNAs) are involved in the process of muscle cell differentiation and play an important role. Previous studies have shown that lncRNA-MEG3 promotes the differentiation of porcine skeletal muscle satellite cells (PSCs), but the ...
Quan Liu, Mengxun Li, Su Xie, Cheng Tian, Jiaxuan Li, Yuan Wang, Xin Li, Changchun Li   +7 more
doaj   +1 more source

E3 ligase Deltex2 accelerates myoblast proliferation and inhibits myoblast differentiation by targeting Pax7 and MyoD, respectively

Acta Biochimica et Biophysica Sinica, 2023
E3 ubiquitin ligases are closely related to cell division, differentiation, and survival in all eukaryotes and play crucial regulatory roles in multiple biological processes and diseases. While Deltex2, as a member of the DELTEX family ubiquitin ligases,
Zhu Qi, Liang Ziyun, Cai Shufang, Tong Xian, Wang Xiaoyu, Li Enru, Chen Yaosheng, Mo Delin   +7 more
doaj   +1 more source

Evolutionary Conservation of MyoD Function and Differential Utilization of E Proteins

Developmental Biology, 1999
The formation of striated muscle in both vertebrates and invertebrates involves the activity of the MyoD family of basic-helix-loop-helix (bHLH) transcription factors. The high degree of evolutionary conservation of MyoD-related proteins, both in the sequence of their bHLH domains and in their general developmental expression patterns, suggests that ...
Zhang, Jian-Min, Chen, Lihsia, Krause, Michael, Fire, Andrew, Paterson, Bruce M   +4 more
openaire   +2 more sources

Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation [PDF]

Development, 2007
The basic helix-loop-helix (bHLH) transcription factor Myod directly regulates gene expression throughout the program of skeletal muscle differentiation. It is not known how a Myod-driven myogenic program is modulated to achieve muscle fiber-type-specific gene expression.
Lisa, Maves, Andrew Jan, Waskiewicz, Biswajit, Paul, Yi, Cao, Ashlee, Tyler, Cecilia B, Moens, Stephen J, Tapscott   +6 more
openaire   +2 more sources

Interaction of MyoD Family Proteins with Enhancers of Acetylcholine Receptor Subunit Genes in Vivo [PDF]

Journal of Biological Chemistry, 2000
The myogenic determination factors (MDFs) are transcriptional activators that target E boxes in many muscle-specific promoters, including those of the genes coding for the subunits of the acetylcholine receptor. It is not known, however, if in vivo a given E box in a transcriptionally active gene is occupied, either uniquely by one MDF or randomly by ...
S, Liu, D S, Spinner, M M, Schmidt, J A, Danielsson, S, Wang, J, Schmidt   +5 more
openaire   +2 more sources

MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB

Cell Reports, 2016
MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle metabolism has not been explored. In a genome-wide ChIP-seq analysis of skeletal muscle cells,
Jonathan Shintaku, Jennifer M. Peterson, Erin E. Talbert, Jin-Mo Gu, Katherine J. Ladner, Dustin R. Williams, Kambiz Mousavi, Ruoning Wang, Vittorio Sartorelli, Denis C. Guttridge   +9 more
doaj   +1 more source

Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling–mediated muscular hypertrophy and myoblast differentiation

Journal of Ginseng Research, 2020
Background: As a process of aging, skeletal muscle mass and function gradually decrease. It is reported that ginsenoside Rb1 and Rb2 play a role as AMP-activated protein kinase activator, resulting in regulating glucose homeostasis, and Rb1 reduces ...
Ga-Yeon Go, Ayoung Jo, Dong-Wan Seo, Woo-Young Kim, Yong Kee Kim, Eui-Young So, Qian Chen, Jong-Sun Kang, Gyu-Un Bae, Sang-Jin Lee   +9 more
doaj   +1 more source

Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells [PDF]

Genes & Development, 2019
The balance between proliferation and differentiation of muscle stem cells is tightly controlled, ensuring the maintenance of a cellular pool needed for muscle growth and repair. We demonstrate here that the transcriptional regulator Hes1 controls the balance between proliferation and differentiation of activated muscle stem cells in both developing ...
Lahmann, Ines, Bröhl, Dominique, Zyrianova, Tatiana, Isomura, Akihiro, Czajkowski, Maciej, Kapoor, Varun, Griger, Joscha, Ruffault, Pierre-Louis, Mademtzoglou, Despoina, Zammit, Peter, Wunderlich, Thomas, Spuler, Simone, Kühn, Ralf, Preibisch, Stephan, Wolf, Jana, Kageyama, Ryoichiro, Birchmeier, Carmen   +16 more
openaire   +6 more sources

Visualizing the Needle in the Haystack: In Situ Hybridization With Fluorescent Dendrimers

Biological Procedures Online, 2004
In situ hybridization with 3DNA™ dendrimers is a novel tool for detecting low levels of mRNA in tissue sections and whole embryos. Fluorescently labeled dendrimers were used to identify cells that express mRNA for the skeletal muscle transcription ...
Gerhart Jacquelyn, Baytion Michael, Perlman Jordanna, Neely Christine, Hearon Bridget, Nilsen Thor, Getts Robert, Kadushin James, George-Weinstein Mindy   +8 more
doaj   +1 more source