Results 21 to 30 of about 19,949 (187)
iScience, 2021 Summary: While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation of fibroblasts to myoblasts promotes
Lavinia Bisceglie +11 more
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Differential Cooperation between Heterochromatin Protein HP1 Isoforms and MyoD in Myoblasts [PDF]
Journal of Biological Chemistry, 2008 Mechanisms of transcriptional repression are important during cell differentiation. Mammalian heterochromatin protein 1 isoforms HP1alpha, HP1beta, and HP1gamma play important roles in the regulation of chromatin structure and function. We explored the possibility of different roles for the three HP1 isoforms in an integrated system, skeletal muscle ...
Yahi, Hakima +9 more
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Applied Sciences, 2022 Direct reprogramming of somatic cells to myoblasts and myotubes holds great potential for muscle development, disease modeling and regenerative medicine.
Boram Son +6 more
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Mos Activates Myogenic Differentiation by Promoting Heterodimerization of MyoD and E12 Proteins [PDF]
Molecular and Cellular Biology, 1997 The activities of myogenic basic helix-loop-helix (bHLH) factors are regulated by a number of different positive and negative signals. Extensive information has been published about the molecular mechanisms that interfere with the process of myogenic differentiation, but little is known about the positive signals.
J L, Lenormand +5 more
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Direct Reprogramming of Fibroblasts to Myocytes via Bacterial Injection of MyoD Protein [PDF]
Cellular Reprogramming, 2013 Forced exogenous gene expression has been well characterized as an effective method for directing both cellular differentiation and dedifferentiation. However, transgene expression is not amenable for therapeutic application due to potential insertional mutagenesis.
Candace, Bichsel +6 more
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International Brazilian Journal of Urology, 2015 Purpose:RNA activation (RNAa) is a mechanism of gene activation triggered by promoter-targeted small double stranded RNAs (dsRNAs), also known as small activating RNAs (saRNAs).
Chenghe Wang +10 more
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Growth factors improve the proliferation of Jeju black pig muscle cells by regulating myogenic differentiation 1 and growth-related genes [PDF]
Animal Bioscience, 2021 Objective The growth rate of pigs is related to differentiation and proliferation of muscle cells, which are regulated by growth factors and expression of growth-related genes. Thus, the objective of this study was to establish optimal culture conditions
Jinryong Park +8 more
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Specific Activation of the Acetylcholine Receptor Subunit Genes by MyoD Family Proteins [PDF]
Journal of Biological Chemistry, 2003 Whether the myogenic regulatory factors (MRFs) of the MyoD family can discriminate among the muscle gene targets for the proper and reproducible formation of skeletal muscle is a recurrent question. We have previously shown that, in Xenopus laevis, myogenin specifically transactivated muscle structural genes in vivo.
Frédéric, Charbonnier +6 more
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Data on MyoD reduction by autophagy in C2C12 cells
Data in Brief, 2017 Autophagy is a highly regulated physiologic mechanism in which cells maintain homeostasis by degrading excessive or unnecessary proteins and damaged or aged organelles through the lysosomal machinery (Yorimitsu and Klionsky, 2005) [1].
Yeong-Min Yoo, Yung Chul Park
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Applied Sciences, 2023 Sarcopenia is an aging-related disease that involves the gradual loss of muscle mass and function. However, no suitable therapeutic drugs are currently available. Accordingly, the purpose of the present study was to evaluate the effectiveness of rosemary
Jun Ho Lee +6 more
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