Results 1 to 10 of about 19,918 (156)

Nandrolone-induced nuclear accumulation of MyoD protein is mediated by Numb, a Notch inhibitor, in C2C12 myoblasts [PDF]

Physiological Reports, 2018
Signaling via the androgen receptor (AR) stimulates myogenic progenitor differentiation. In addition, myogenic differentiation factor D (MyoD) and Numb, a Notch inhibitor, play key roles in regulating myogenic differentiation. Nandrolone, an anabolic steroid, upregulates both MyoD and Numb expression in myogenic cells. However, the molecular mechanisms
Christopher Cardozo
exaly   +4 more sources

MyoD and myogenin protein expression in skeletal muscles of senile rats [PDF]

Cell and Tissue Research, 2003
We analyzed the level of protein expression of two myogenic regulatory factors (MRFs), MyoD and myogenin, in senile skeletal muscles and determined the cellular source of their production in young adult (4 months old), old (24, 26, and 28 months old), and senile (32 months old) male rats. Immunoblotting demonstrated levels of myogenin approximately 3.2,
Tatiana Kostrominova, Eduard I Dedkov, Bruce M Carlson   +2 more
exaly   +4 more sources

PAX7 and MyoD Proteins Expression in Response to Eccentric and Concentric Resistance Exercise in Active Young Men [PDF]

Cell Journal, 2023
Objective: Satellite cells play an important role in muscle regeneration, which this process can be affected by differentgenes including PAX7 and MyoD. Exercise training known as an important strategy for mediating the satellite cell’sfunction. Therefore,
Somayeh Karimi Majd, Mandana Gholami, Behzad Bazgir   +2 more
doaj   +3 more sources

Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma [PDF]

eLife, 2022
Myogenic regulatory factors (MRFs) are pivotal transcription factors in myogenic differentiation. MyoD commits cells to the skeletal muscle lineage by inducing myogenic genes through recruitment of chromatin remodelers to its target loci.
Tsuyoshi Morita, Ken'ichiro Hayashi
doaj   +3 more sources

Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoD [PDF]

Biochemical and Biophysical Research Communications, 2008
The recruitment of the bromodomains of CREB-binding protein (CBP) and p300 by the acetylated myogenic transcription factor MyoD was previously shown to be critical for the enhanced MyoD transcriptional activity following acetylation at its Lys99 and Lys102 positions.
Lanlan Wei, Zhenghe Wang, Weiping Zheng   +2 more
exaly   +3 more sources

CHAMP1 is an essential regulator for human myoblast fusion and muscle development [PDF]

Nature Communications
Human skeletal muscle comprises myofibers formed by fusion of thousands of myoblasts. This process depends on tightly regulated, muscle-specific fusogens, but its genetic control remains poorly understood.
Haifeng Zhang, Min Zhou, Zheng Zhang, Zhaoning Wang, Ruifeng Shi, Yushu Wang, Xiaolin Wei, Renjie Shang, Jianwen Li, Cuiyu He, Jin Xie, Yarui Diao, Pengpeng Bi   +12 more
doaj   +2 more sources

Skipjack tuna bone derived biocalcium ameliorates C2C12 myotube atrophy through microRNA29b regulation [PDF]

Scientific Reports
We investigated the protective effects of skipjack tuna (Katsuwonus pelamis) bone-derived biocalcium (Bio) against dexamethasone-induced atrophy in C2C12 myotubes. Bio rescued atrophic morphology, increasing myotube diameter dose-dependently.
Sompot Jantarawong, Theeraphol Senphan, Chanokwanan Youngruk, Nicha Thongchai, Papitchaya Watcharanurak, Pasjan Satrimafitrah, Yuya Yamaguchi, Kazuya Hasegawa, Yutthana Pengjam   +8 more
doaj   +2 more sources

Generation of a MyoD knock-in reporter mouse line to study muscle stem cell dynamics and heterogeneity

iScience, 2023
Summary: Myoblast determination protein 1 (MyoD) dynamics define the activation status of muscle stem cells (MuSCs), aiding in muscle tissue regeneration after injury.
Ryo Fujita, Seiya Mizuno, Taketaro Sadahiro, Takuto Hayashi, Takehito Sugasawa, Fumihiro Sugiyama, Yusuke Ono, Satoru Takahashi, Masaki Ieda   +8 more
doaj   +1 more source

Human p300 Protein Is a Coactivator for the Transcription Factor MyoD [PDF]

Journal of Biological Chemistry, 1996
Human p300 protein is a cellular target of adenoviral E1A oncoprotein and a potential transcriptional coactivator. Both p300 and Rb family protein-binding regions of E1A are required for the repression of muscle gene expression, which is regulated by MyoD family transactivators. This implies that p300 is involved in MyoD-dependent transactivation.
Yuan WC, Condorelli G, Caruso M, Felsani A, Giordano A   +4 more
openaire   +4 more sources

Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation. [PDF]

PLoS ONE, 2011
When mouse myoblasts or satellite cells differentiate in culture, the expression of myogenic regulatory factor, MyoD, is downregulated in a subset of cells that do not differentiate.
Joel Alter, Eyal Bengal
doaj   +1 more source