Results 11 to 20 of about 19,949 (187)
CREB-binding Protein/p300 Activates MyoD by Acetylation [PDF]
Journal of Biological Chemistry, 2000 The myogenic protein MyoD requires two nuclear histone acetyltransferases, CREB-binding protein (CBP)/p300 and PCAF, to transactivate muscle promoters. MyoD is acetylated by PCAF in vitro, which seems to increase its affinity for DNA. We here show that MyoD is constitutively acetylated in muscle cells.
A, Polesskaya +8 more
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Biosensors, 2023 The principles of myogenesis play crucial roles in the production of cultured meat, and identifying protein stimulators associated with myogenesis holds great potential to enhance the efficiency of this process.
In-Sun Yu +6 more
doaj +1 more source
A Novel Rb- and p300-Binding Protein Inhibits Transactivation by MyoD [PDF]
Molecular and Cellular Biology, 2000 The retinoblastoma protein (Rb) regulates both the cell cycle and tissue-specific transcription, by modulating the activity of factors that associate with its A-B and C pockets. In skeletal muscle, Rb has been reported to regulate irreversible cell cycle exit and muscle-specific transcription. To identify factors interacting with Rb in muscle cells, we
W R, MacLellan +3 more
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MyoD is a 3D genome structure organizer for muscle cell identity
Nature Communications, 2022 Pioneer transcription factors (TFs) have been proposed to act as protein anchors to orchestrate cell type-specific 3D genome architecture. MyoD is a pioneer TF for myogenic lineage specification.
Ruiting Wang +19 more
doaj +1 more source
Muscle LIM Protein Promotes Myogenesis by Enhancing the Activity of MyoD [PDF]
Molecular and Cellular Biology, 1997 The muscle LIM protein (MLP) is a muscle-specific LIM-only factor that exhibits a dual subcellular localization, being present in both the nucleus and in the cytoplasm. Overexpression of MLP in C2C12 myoblasts enhances skeletal myogenesis, whereas inhibition of MLP activity blocks terminal differentiation.
Y, Kong +3 more
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The core binding factor CBF negatively regulates skeletal muscle terminal differentiation. [PDF]
PLoS ONE, 2010 BACKGROUND: Core Binding Factor or CBF is a transcription factor composed of two subunits, Runx1/AML-1 and CBF beta or CBFbeta. CBF was originally described as a regulator of hematopoiesis.
Ophélie Philipot +6 more
doaj +1 more source
The MyoD-Inducible p204 Protein Overcomes the Inhibition of Myoblast Differentiation by Id Proteins [PDF]
Molecular and Cellular Biology, 2002 The murine p204 protein level is highest in heart and skeletal muscle. During the fusion of cultured myoblasts to myotubes, the p204 level increases due to transcription dependent on the muscle-specific MyoD protein, and p204 is phosphorylated and translocated from the nucleus to the cytoplasm.
Chuan-ju, Liu +3 more
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Scientific Reports, 2021 MYOD-induced microRNA-494-3p expression inhibits fast oxidative myotube formation by downregulating myosin heavy chain 2 (MYH2) in human induced pluripotent stem cells (hiPSCs) during skeletal myogenesis. However, the molecular mechanisms regulating MYH2
Hirotaka Iwasaki +10 more
doaj +1 more source
MyoD Synergizes with the E-Protein HEBβ To Induce Myogenic Differentiation [PDF]
Molecular and Cellular Biology, 2006 The MyoD family of basic helix-loop-helix transcription factors function as heterodimers with members of the E-protein family to induce myogenic gene activation. The E-protein HEB is alternatively spliced to generate alpha and beta isoforms. While the function of these molecules has been studied in other cell types, questions persist regarding the ...
Parker, Maura H. +4 more
openaire +3 more sources
Journal of Developmental Biology, 2023 The MyoD gene was duplicated during the teleost whole genome duplication and, while a second MyoD gene (MyoD2) was subsequently lost from the genomes of some lineages (including zebrafish), many fish lineages (including Alcolapia species) have retained ...
Lewis J. White +4 more
doaj +1 more source