Results 11 to 20 of about 32,334 (225)

A mini-review of TAT-MyoD fused proteins: state of the art and problems to solve. [PDF]

European Journal of Translational Myology, 2018
open6siopenPatruno, M; Melotti L.; Gomiero, C; Sacchetto, R; Topel, O; Martinello, T.Patruno, M; Melotti, Luca; Gomiero, C; Sacchetto, R; Topel, O; Martinello ...
Patruno, M, MELOTTI, LUCA, Gomiero, C, Sacchetto, R, Topel, O, Martinello, T.   +5 more
core   +6 more sources

Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma [PDF]

eLife, 2022
Myogenic regulatory factors (MRFs) are pivotal transcription factors in myogenic differentiation. MyoD commits cells to the skeletal muscle lineage by inducing myogenic genes through recruitment of chromatin remodelers to its target loci.
Tsuyoshi Morita, Ken'ichiro Hayashi
doaj   +3 more sources

Human p300 Protein Is a Coactivator for the Transcription Factor MyoD [PDF]

Journal of Biological Chemistry, 1996
Human p300 protein is a cellular target of adenoviral E1A oncoprotein and a potential transcriptional coactivator. Both p300 and Rb family protein-binding regions of E1A are required for the repression of muscle gene expression, which is regulated by MyoD family transactivators. This implies that p300 is involved in MyoD-dependent transactivation.
Yuan WC, Condorelli G, Caruso M, Felsani A, Giordano A   +4 more
openaire   +4 more sources

CREB-binding Protein/p300 Activates MyoD by Acetylation [PDF]

Journal of Biological Chemistry, 2000
The myogenic protein MyoD requires two nuclear histone acetyltransferases, CREB-binding protein (CBP)/p300 and PCAF, to transactivate muscle promoters. MyoD is acetylated by PCAF in vitro, which seems to increase its affinity for DNA. We here show that MyoD is constitutively acetylated in muscle cells.
A, Polesskaya, A, Duquet, I, Naguibneva, C, Weise, A, Vervisch, E, Bengal, F, Hucho, P, Robin, A, Harel-Bellan   +8 more
openaire   +2 more sources

Deubiquitinase YOD1 Inhibition Suppresses DEX- and Denervation-Induced Muscle Atrophy Through MAFbx Destabilization. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Backgrounds Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle‐specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin–proteasome system remains unclear. This study aims to identify a deubiquitinase (DUB)
Chae J, Woo SM, Seo SU, Yook S, Cho HJ, Lee JY, Min KJ, Park J, Ryu D, Kwon TK.   +9 more
europepmc   +2 more sources

Muscle LIM Protein Promotes Myogenesis by Enhancing the Activity of MyoD [PDF]

Molecular and Cellular Biology, 1997
The muscle LIM protein (MLP) is a muscle-specific LIM-only factor that exhibits a dual subcellular localization, being present in both the nucleus and in the cytoplasm. Overexpression of MLP in C2C12 myoblasts enhances skeletal myogenesis, whereas inhibition of MLP activity blocks terminal differentiation.
Y, Kong, M J, Flick, A J, Kudla, S F, Konieczny   +3 more
openaire   +2 more sources

A Novel Rb- and p300-Binding Protein Inhibits Transactivation by MyoD [PDF]

Molecular and Cellular Biology, 2000
The retinoblastoma protein (Rb) regulates both the cell cycle and tissue-specific transcription, by modulating the activity of factors that associate with its A-B and C pockets. In skeletal muscle, Rb has been reported to regulate irreversible cell cycle exit and muscle-specific transcription. To identify factors interacting with Rb in muscle cells, we
W R, MacLellan, G, Xiao, M, Abdellatif, M D, Schneider   +3 more
openaire   +2 more sources

The MyoD-Inducible p204 Protein Overcomes the Inhibition of Myoblast Differentiation by Id Proteins [PDF]

Molecular and Cellular Biology, 2002
The murine p204 protein level is highest in heart and skeletal muscle. During the fusion of cultured myoblasts to myotubes, the p204 level increases due to transcription dependent on the muscle-specific MyoD protein, and p204 is phosphorylated and translocated from the nucleus to the cytoplasm.
Chuan-ju, Liu, Bo, Ding, Hong, Wang, Peter, Lengyel   +3 more
openaire   +2 more sources

MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells

Scientific Reports, 2021
MYOD-induced microRNA-494-3p expression inhibits fast oxidative myotube formation by downregulating myosin heavy chain 2 (MYH2) in human induced pluripotent stem cells (hiPSCs) during skeletal myogenesis. However, the molecular mechanisms regulating MYH2
Hirotaka Iwasaki, Yoshinori Ichihara, Katsutaro Morino, Mengistu Lemecha, Lucia Sugawara, Tatsuya Sawano, Junichiro Miake, Hidetoshi Sakurai, Eiichiro Nishi, Hiroshi Maegawa, Takeshi Imamura   +10 more
doaj   +1 more source

MyoD Synergizes with the E-Protein HEBβ To Induce Myogenic Differentiation [PDF]

Molecular and Cellular Biology, 2006
The MyoD family of basic helix-loop-helix transcription factors function as heterodimers with members of the E-protein family to induce myogenic gene activation. The E-protein HEB is alternatively spliced to generate alpha and beta isoforms. While the function of these molecules has been studied in other cell types, questions persist regarding the ...
Parker, Maura H., Perry, Robert L.S., Fauteux, Melanie C., Berkes, Charlotte A., Rudnicki, Michael A.   +4 more
openaire   +3 more sources