Results 151 to 160 of about 1,180 (165)
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Myoferlin gene silencing decreases Tie-2 expression in vitro and angiogenesis in vivo
Vascular Pharmacology, 2011Angiogenesis consists in the growth of new blood vessels from pre-existing ones. Although anti-angiogenesis interventions have been shown to have therapeutic properties in human diseases such as cancer, their effect is only partial and the identification of novel modulators of angiogenesis is warranted.
Carol Yu +2 more
exaly +3 more sources
PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis
Oncogene, 2019PINCH-1 is a cytoplasmic component of the cell-extracellular matrix (ECM) adhesion machine that is frequently overexpressed in cancer. The functions and mechanism of PINCH-1 in cancer, however, remain to be determined. Here, we show that PINCH-1 interacts with myoferlin, a transmembrane protein that is critical for cancer progression.
Tao Qian +11 more
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Myoferlin Regulates Vascular Endothelial Growth Factor Receptor-2 Stability and Function [PDF]
Journal of Biological Chemistry, 2007 Myoferlin and dysferlin are members of the ferlin family of membrane proteins. Recent studies have shown that mutation or genetic disruption of myoferlin or dysferlin promotes muscular dystrophy-related phenotypes in mice, which are the result of impaired plasma membrane integrity. However, no biological functions have been ascribed to myoferlin in non-
Pascal N Bernatchez +2 more
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Bacterial LPS differentially modulates the expression of Myoferlin in trophoblast cells
Journal of Reproductive Immunology, 2015Myoferlin, one of the members of the Ferlin family is a membrane protein encoded by the MYOF gene and found in cell membranes, nuclear membranes and cytoplasmic vesicles. A high expression ofMyoferlin is observed in skeletal and cardiacmuscles and weak expression in the brain, kidney and placenta.
N. Muhandiram, A. Jabeen, N. Fernàndez
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The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma
Oncogene, 2017Megakaryoblastic Leukemia 1 and 2 (MKL1/2) are transcriptional coactivators of Serum Response Factor (SRF) with an essential role for hepatocellular carcinoma (HCC) growth and oncogene-induced senescence. In this report, we identified myoferlin as a novel MKL/SRF target gene by gene expression profiling and verification in vivo in HCC xenografts ...
C Hermanns +16 more
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A myoferlin gain‐of‐function variant associates with a new type of hereditary angioedema
Allergy, 2020Anastasia Ariano +11 more
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Expression of Myoferlin in Human and Murine Carcinoma Tumors
The American Journal of Pathology, 2013Cleo Leung +4 more
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Myoferlin, a multifunctional protein in normal cells, has novel and key roles in various cancers
Journal of Cellular and Molecular Medicine, 2019Bolun Zhou +2 more
exaly