Results 151 to 160 of about 1,884 (173)
Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness [PDF]
Oncogene, 2018 Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death. Therapeutic options remain very limited and are based on classical chemotherapies.
Gilles Rademaker +2 more
exaly +6 more sources
Myoferlin is critical for endocytosis in endothelial cells [PDF]
American Journal of Physiology - Cell Physiology, 2009 Myoferlin is a member of the ferlin family of proteins that promotes endomembrane fusion with the plasma membrane in muscle cells and endothelial cells. In addition, myoferlin is necessary for the surface expression of vascular endothelial growth factor receptor 2 through the formation of a protein complex with dynamin-2 (Dyn-2).
William C Sessa
exaly +3 more sources
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth [PDF]
Nature Cell Biology, 2021 Lysosomes must maintain the integrity of their limiting membrane to ensure efficient fusion with incoming organelles and degradation of substrates within their lumen. Pancreatic cancer cells upregulate lysosomal biogenesis to enhance nutrient recycling and stress resistance, but it is unknown whether dedicated programmes for maintaining the integrity ...
Suprit Gupta +2 more
exaly +7 more sources
Myoferlin, a candidate gene and potential modifier of muscular dystrophy [PDF]
Human Molecular Genetics, 2000 Dysferlin, the gene product of the limb girdle muscular dystrophy (LGMD) 2B locus, encodes a membrane-associated protein with homology to Caenorhabditis elegans fer-1. Humans with mutations in dysferlin ( DYSF ) develop muscle weakness that affects both proximal and distal muscles.
Elizabeth M Mcnally, Dawn Belt Davis
exaly +3 more sources
Expression of Myoferlin in Skeletal Muscles of Patients with Dysferlinopathy
Tohoku Journal of Experimental Medicine, 2006 Myoferlin is a novel protein of unknown function with high homology to dysferlin, the gene mutations of which cause limb girdle muscular dystrophy type 2B and Miyoshi myopathy. The myoferlin gene seems to be a candidate for the modifier, and because of the high homology to dysferlin myoferlin may work as a compensator for the absence of dysferlin in ...
Ichizo Nishino
exaly +4 more sources
Myoferlin Regulates Vascular Endothelial Growth Factor Receptor-2 Stability and Function [PDF]
Journal of Biological Chemistry, 2007 Myoferlin and dysferlin are members of the ferlin family of membrane proteins. Recent studies have shown that mutation or genetic disruption of myoferlin or dysferlin promotes muscular dystrophy-related phenotypes in mice, which are the result of impaired plasma membrane integrity. However, no biological functions have been ascribed to myoferlin in non-
Takahisa Murata +2 more
exaly +3 more sources
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Myoferline gene mutation сan be associated with recurrent angioedema
Russian Journal of Allergy, 2023Hereditary angioedema is a rare genetically determined disease characterized by the recurrent angioedema of various localizations with no response to systemic glucocorticosteroids, antihistamines. In the majority of hereditary angioedema cases C1-inhibitor level or its functional activity is decreased due to a mutation in the SERPING1 gene.
Daria S. Fomina +5 more
openaire +1 more source
PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis
Oncogene, 2019PINCH-1 is a cytoplasmic component of the cell-extracellular matrix (ECM) adhesion machine that is frequently overexpressed in cancer. The functions and mechanism of PINCH-1 in cancer, however, remain to be determined. Here, we show that PINCH-1 interacts with myoferlin, a transmembrane protein that is critical for cancer progression.
Chengmin Liu, Rong Wang, Yi Deng
exaly +3 more sources
The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma
Oncogene, 2017Megakaryoblastic Leukemia 1 and 2 (MKL1/2) are transcriptional coactivators of Serum Response Factor (SRF) with an essential role for hepatocellular carcinoma (HCC) growth and oncogene-induced senescence. In this report, we identified myoferlin as a novel MKL/SRF target gene by gene expression profiling and verification in vivo in HCC xenografts ...
Stephanie Roessler
exaly +3 more sources