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Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer [PDF]
Myoferlin is a multiple C2-domain-containing protein that regulates membrane repair, tyrosine kinase receptor function and endocytosis in myoblasts and endothelial cells. Recently it has been reported as overexpressed in several cancers and shown to contribute to proliferation, migration and invasion of cancer cells.
Blomme, Arnaud +26 more
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Myoferlin gene silencing decreases Tie-2 expression in vitro and angiogenesis in vivo
Vascular Pharmacology, 2011Angiogenesis consists in the growth of new blood vessels from pre-existing ones. Although anti-angiogenesis interventions have been shown to have therapeutic properties in human diseases such as cancer, their effect is only partial and the identification of novel modulators of angiogenesis is warranted.
Carol, Yu +5 more
exaly +3 more sources
Bacterial LPS differentially modulates the expression of Myoferlin in trophoblast cells
Journal of Reproductive Immunology, 2015Myoferlin, one of the members of the Ferlin family is a membrane protein encoded by the MYOF gene and found in cell membranes, nuclear membranes and cytoplasmic vesicles. A high expression ofMyoferlin is observed in skeletal and cardiacmuscles and weak expression in the brain, kidney and placenta.
N. Muhandiram, A. Jabeen, N. Fernàndez
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Expression of Myoferlin in Human and Murine Carcinoma Tumors
The American Journal of Pathology, 2013Cleo Leung +4 more
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A myoferlin gain‐of‐function variant associates with a new type of hereditary angioedema
Allergy, 2020Anastasia Ariano +11 more
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Myoferlin, a multifunctional protein in normal cells, has novel and key roles in various cancers
Journal of Cellular and Molecular Medicine, 2019Bolun Zhou, Chenxuan Zhao, Weidong Liu
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