Results 131 to 140 of about 33,732 (260)

Effects of inhibition of Janus kinase signalling during controlled mechanical ventilation on the rate of skeletal muscle protein synthesis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend 2H2O labelling was used to examine muscle protein fractional synthesis rates (FSR) in an intensive care unit (ICU) model and non‐anaesthetized control rats, and to compare the effects of a Janus kinase (JAK)/STAT inhibitor on protein FSR in the ICU model.
William J. Evans   +9 more
wiley   +1 more source

Sex differences in the physiological response to acute anterior cruciate ligament overuse

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend With equivalent in vivo fatigue loading of the anterior cruciate ligament (ACL), females accumulate more tissue damage and mount a slower reparative response than males, when the applied loads between sexes are equivalent. By contrast, males accumulate less tissue damage and mount a robust reparative response that includes ...
Stephen H. Schlecht   +5 more
wiley   +1 more source

Determinants of maximal oxygen uptake in highly trained females and males: a mechanistic study of sex differences using advanced invasive methods

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The results from this study show that maximal cardiac output, stroke volume and leg blood flow are similar between highly trained females and males after normalisation to lean body mass (LBM). However, the 10% higher haemoglobin concentration ([Hb]) and arterial O2 content in males result in higher systemic and leg O2 delivery ...
Øyvind Skattebo   +11 more
wiley   +1 more source

R405W Desmin Knock‐In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Mutations in the desmin gene cause skeletal myopathies and cardiomyopathies. The objective of this study was to elucidate the molecular pathology induced by the expression of R405W mutant desmin in murine skeletal muscle. Methods A comprehensive characterization of the skeletal muscle pathology in hetero‐ and homozygous R405W desmin
Sabrina Batonnet‐Pichon   +19 more
wiley   +1 more source

Engineering Artificial Spider Silk From Biomimetic Synthesis to Advanced Applications

open access: yesSmartSys, Volume 1, Issue 3, December 2025.
ABSTRACT Polymeric materials research is increasingly directed toward biomimicry, exploring designs derived from nature's long evolutionary processes to enhance material properties and sustainability. Scientists have long recognized that spider silk, as a natural polymer, possesses exceptional physicochemical properties, including high tensile strength,
Boren Zhou   +4 more
wiley   +1 more source

Exploring Desmin as a Potential Modifier in Duchenne Muscular Dystrophy–Associated Cardiomyopathy

open access: yesActa Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Duchenne muscular dystrophy (DMD), a rare X‐linked genetic disorder, is affecting skeletal and cardiac muscles due to the loss of the dystrophin protein. Modifier proteins, whose expression is altered in DMD patients, may influence disease progression.
Brice‐Emmanuel Guennec   +12 more
wiley   +1 more source

Mitochondrial Dysfunction Contributes to Decompensation in a Zebrafish Model of Isoproterenol‐Induced Heart Failure

open access: yesActa Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Heart failure is a clinical syndrome where the heart's structural or functional impairment leads to inadequate blood flow to meet the body's metabolic demands. Mitochondrial dysfunction is increasingly recognized as a central contributor underlying the contractile impairment observed in the failing heart.
Manuel Vicente   +6 more
wiley   +1 more source

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