Results 121 to 130 of about 2,944 (198)
Insulin and islet cell transplants: effects on diabetic rat cardiac myofibril ATPase
, 1987 Streptozotocin-induced diabetes results in depression of growth rate, cardiac myofibril ATPase activity, and elevated plasma glucose levels. Reversibility of these changes with daily insulin injections and pancreatic islet cell transplants was ...
I. M. MacLean +2 more
core +1 more source
iMeta, Volume 5, Issue 5, October 2026.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
, 1985 We tested the hypothesis that exercise training provides a stimulus that could modify the decrement in mitochondria-to-myofibril volume ratio characteristic of myocardial cells hypertrophied in response to a pressure overload. Spontaneously hypertensive
R. J. Tomanek, R. P. Crisman
core +1 more source
MicroRNA–mRNA Networks in Skeletal Muscle of Tailored Pig Models for Dystrophinopathies
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Background Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are X‐linked dystrophinopathies caused by mutations in the dystrophin (DMD) gene. A common DMD‐causing mutation in humans is exon 52 deletion (DMDΔ52), which disrupts the reading frame and abolishes dystrophin expression.
Sarah Reschke +9 more
wiley +1 more source
Intramuscular Fat as a Biomarker of Muscle Health: Strengths, Limitations and Open Challenges
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Intramuscular fat (IMF), also known as myosteatosis, refers to the accumulation of lipids within and around skeletal muscle fibres. Excess IMF is increasingly recognised as a sign of poor muscle quality, linked to reductions in strength, power and mobility, and associated with adverse outcomes in metabolic disease, osteoarthritis ...
Christopher Spence +4 more
wiley +1 more source
Recent Advances in Oriented Hydrogels: From Fundamental Mechanisms to Future Challenges
SusMat, Volume 6, Issue 5, October 2026.Traditional hydrogels suffer from weak mechanical properties and limited functionality due to their random polymer networks. This review comprehensively summarizes the reinforcement mechanisms of oriented structure for hydrogels, the design/fabrication strategies, and the latest application progress of high‐strength oriented hydrogels.
Chang Xu, Xijing Zhuang
wiley +1 more source
Mechanism of Oleic Add-Induced Myofibril Disassembly in Rat Cardiomyocytes
, 2008 This study investigated the mechanism of oleic acid (OA)- induced disassembly of myofibrils in cardiomyocytes. OA treatment disrupted myofibrils, as revealed by the disorganization of several sarcomeric proteins.
HUANG, YUAHN-SIEH;WANG, SEU-MEI;HSU, KWAN-LIH;TSENG, YUNG-ZU;WU, JIAHN-CHUN +1 more
core
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Aim Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear. Methods A muscle atrophy model was established
Wan Yu, Yanteng Wang, Na Li, Difei Wang
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 20, Page 8379-8427, 15 October 2026.Abstract figure legend This study uses systems modelling to demonstrate a role of SOCE in sustained force generation during exercise. SOCE leads to two competing effects on contractile force in myofibres – increased cross‐bridge cycling due to elevated myoplasmic Ca2+$\text{Ca}^{2+}$ enhances force, whereas increased accumulation of myoplasmic ...
Emmet A. Francis +3 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 20, Page 8523-8541, 15 October 2026.Abstract figure legend Skeletal muscle structure was analysed at three levels in young vs. aged humans, and in young vs. aged mice subjected to unilateral hindlimb immobilization to model disuse. (1) Macroscopic: magnetic resonance imaging of the thigh (human) and wet mass of individual hindlimb muscles (mouse) revealed that both ageing and disuse ...
Ramy K. A. Sayed +13 more
wiley +1 more source