Results 101 to 110 of about 13,101 (238)
The Journal of Physiology, EarlyView.Abstract figure legend The results from this study show that maximal cardiac output, stroke volume and leg blood flow are similar between highly trained females and males after normalisation to lean body mass (LBM). However, the 10% higher haemoglobin concentration ([Hb]) and arterial O2 content in males result in higher systemic and leg O2 delivery ...
Øyvind Skattebo +11 more
wiley +1 more source
Video2_Cooperation between myofibril growth and costamere maturation in human cardiomyocytes.AVI
, 2022 Costameres, as striated muscle-specific cell adhesions, anchor both M-lines and Z-lines of the sarcomeres to the extracellular matrix. Previous studies have demonstrated that costameres intimately participate in the initial assembly of myofibrils ...
Huaiyu Shi (8795675) +4 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
Liver cell line derived conditioned medium enhances myofibril organization of primary rat cardiomyocytes [PDF]
, 2016 Cardiomyocytes are the fundamental cells of the heart and play an important role in engineering of tissue constructs for regenerative medicine and drug discovery.
Chung, Alice Mira +4 more
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The Journal of Physiology, EarlyView.Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li +19 more
wiley +1 more source
Heterozygous OGDH Variants Are Involved in Peripheral Neuropathy With Ataxia and Optical Atrophy
JIMD Reports, Volume 67, Issue 4, July 2026.ABSTRACT 2‐oxyglutarate dehydrogenase (OGDH) encodes an E1 component of α‐ketoglutarate dehydrogenase complex that plays a pivotal role in the Krebs cycle. Biallelic variants in OGDH have been reported to cause an early‐onset neurodevelopmental and mitochondrial disorder.
Liedewei Van de Vondel +13 more
wiley +1 more source
Assessing Cardiac Contractility From Single Molecules to Whole Hearts
JACC: Basic to Translational ScienceSummary: Fundamentally, the heart needs to generate sufficient force and power output to dynamically meet the needs of the body. Cardiomyocytes contain specialized structures referred to as sarcomeres that power and regulate contraction.
Ankit Garg, MD, PhD +2 more
doaj +1 more source
Mechanism of Oleic Add-Induced Myofibril Disassembly in Rat Cardiomyocytes
, 2008 This study investigated the mechanism of oleic acid (OA)- induced disassembly of myofibrils in cardiomyocytes. OA treatment disrupted myofibrils, as revealed by the disorganization of several sarcomeric proteins.
HUANG, YUAHN-SIEH;WANG, SEU-MEI;HSU, KWAN-LIH;TSENG, YUNG-ZU;WU, JIAHN-CHUN +1 more
core
Pvr and Pvf2 Are Essential for Valve Cell Differentiation in the Larval Drosophila Heart
genesis, Volume 64, Issue 3, June 2026.ABSTRACT The directionality of blood flow is regulated by heart valves, among other things. While the heart valves in vertebrates are multicellular and complex, the valve in the Drosophila heart consists of exactly two highly specialized cells. They arise during early larval development from two cardiomyocytes, those that form the boundary between the ...
Heiko Meyer +3 more
wiley +1 more source