Results 101 to 110 of about 21,531 (244)

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Assessing Cardiac Contractility From Single Molecules to Whole Hearts

JACC: Basic to Translational Science
Summary: Fundamentally, the heart needs to generate sufficient force and power output to dynamically meet the needs of the body. Cardiomyocytes contain specialized structures referred to as sarcomeres that power and regulate contraction.
Ankit Garg, MD, PhD, Kory J. Lavine, MD, PhD, Michael J. Greenberg, PhD   +2 more
doaj   +1 more source

Mechanical characterization of skeletal muscle myofibrils

Biophysical Journal, 1996
A new instrument, based on a technique described previously, is presented for studying mechanics of micron-scale preparations of two to three myofibrils or single myofibrils from muscle. Forces in the nanonewton to micronewton range are measurable with 0.5-ms time resolution.
Friedman, A.L., Goldman, Y.E.
openaire   +2 more sources

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Distinct distributions of myosin motor conformations during contraction of slow and fast skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend We recorded time‐resolved small‐angle X‐ray diffraction patterns from rat soleus muscles during fixed‐end twitch and tetanic contractions to investigate the structural basis of the lower fixed‐end force generated by these muscles compared with fast muscles, such as the mouse extensor digitorum longus (EDL).
Cameron Hill, Michaeljohn Kalakoutis, Alice Arcidiacono, Yanhong Wang, Emma Smith, Elisabetta Brunello, Luca Fusi, Malcolm Irving   +7 more
wiley   +1 more source

Functional and Structural Adaptations of Skeletal Muscle to Microgravity [PDF]

, 2001
Our purpose is to summarize the major effects of space travel on skeletal muscle with particular emphasis on factors that alter function. The primary deleterious changes are muscle atrophy and the associated decline in peak force and power.
Fitts, Robert, Riley, Danny R, Widrick, Jeffrey J   +2 more
core   +1 more source

Deubiquitinase YOD1 Inhibition Suppresses DEX‐ and Denervation‐Induced Muscle Atrophy Through MAFbx Destabilization

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Backgrounds Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle‐specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin–proteasome system remains unclear. This study aims to identify a deubiquitinase (DUB)
Jongbeom Chae, Seon Min Woo, Seung Un Seo, Simmyung Yook, Hyo Je Cho, Jung Yeol Lee, Kyoung jin Min, Junhyeon Park, Dongryeol Ryu, Taeg Kyu Kwon   +9 more
wiley   +1 more source

Functional Characterization of a Drosophila Transgenic Line Expressing a Chimeric Flightin: Implications on Flight Muscle Structure and Mating Behavior [PDF]

, 2015
The asynchronous, indirect flight muscles (IFM) of Drosophila are characterized by their remarkable crystalline myofilament lattice structure that has been proposed to have evolved to power skilled flight for survival, and to produce male courtship song,
Athalye, Harshal
core   +1 more source

Polymorphic myopathological findings in a 77‐year‐old woman with oculo‐bulbo‐facial and distal weakness

Brain Pathology, EarlyView.
Michele Tosi, Angela Puma, Elena Faedo, Gianmarco Severa, Luisa Villa, Sabrina Sacconi, Edoardo Malfatti   +6 more
wiley   +1 more source

Structural Characterization of Cardiac Free‐Running Purkinje Fibers Using Inhomogeneous Magnetization Transfer (ihMT): A Proof of Concept MRI‐Histology Approach

NMR in Biomedicine, Volume 39, Issue 6, June 2026.
The cardiac Purkinje network is essential for synchronized ventricular activation but remains difficult to visualize with conventional MRI due to limited structural contrast. This study demonstrates that inhomogeneous magnetization transfer imaging provides enhanced contrast that differentiates free‐running Purkinje fibers, Purkinje‐Myocardial Junction,
Arash Forodighasemabadi, Evgenios N. Kornaropoulos, Marion Constantin, Lucas Soustelle, Fanny Vaillant, Jude Leury, Richard Walton, Olivier Bernus, Bruno Quesson, Olivier M. Girard, Guillaume Duhamel, Julie Magat   +11 more
wiley   +1 more source