Results 51 to 60 of about 33,732 (260)

Reductions in ATPase activity, actin sliding velocity, and myofibril stability yield muscle dysfunction in Drosophila models of myosin-based Freeman–Sheldon syndrome

open access: yesMolecular Biology of the Cell, 2019
Using Drosophila melanogaster, we created the first animal models for myosin-based Freeman–Sheldon syndrome (FSS), a dominant form of distal arthrogryposis defined by congenital facial and distal skeletal muscle contractures.
Deepti Rao   +5 more
semanticscholar   +1 more source

Effects of Inhomogeneous Myofibril Morphology on Optical Diffraction in Single Muscle Fibers [PDF]

open access: yes, 2008
doi:10.1364/JOSAA.25.003051Laser diffraction is commonly used in physiological research that explores single muscle fibers. Although variations in sarcomere morphological properties have often been observed, their effects on laser diffraction have not ...
Ranasinghesagara, Janaka C.   +1 more
core   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

open access: yesAdvanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana   +2 more
wiley   +1 more source

DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in Drosophila. [PDF]

open access: yes, 2014
During muscle development, myosin and actin containing filaments assemble into the highly organized sarcomeric structure critical for muscle function.
Barkó, Szilvia   +14 more
core   +5 more sources

Actin, α-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells [PDF]

open access: yes, 1975
During the spreading of a population of rat embryo cells, approximately 40% of the cells develop a strikingly regular network which precedes the formation of the straight actin filament bundles seen in the fully spread out cells.
Lazarides, Elias
core   +1 more source

Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis

open access: yesAdvanced Healthcare Materials, EarlyView.
Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim   +10 more
wiley   +1 more source

Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila

open access: yeseLife, 2018
We use the myotendinous junction of Drosophila flight muscles to explore why many integrin associated proteins (IAPs) are needed and how their function is coordinated.
Hannah J. Green   +3 more
semanticscholar   +1 more source

Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss

open access: yesAdvanced Healthcare Materials, EarlyView.
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan   +8 more
wiley   +1 more source

Effect of myofibril passive elastic properties on the mechanical communication between motor proteins on adjacent sarcomeres

open access: yesScientific Reports, 2019
Rapid sarcomere lengthening waves propagate along a single muscle myofibril during spontaneous oscillatory contraction (SPOC). In asynchronous insect flight muscles, SPOC is thought to be almost completely synchronized over the entire myofibril.
T. Washio   +4 more
semanticscholar   +1 more source

The 68,000-Dalton Neurofilament-Associated Polypeptide is a Component of Nonneuronal Cells and of Skeletal Myofibrils [PDF]

open access: yes, 1980
Purified preparations of 10-nm neurofilaments from rat spinal cord and bovine or porcine brain contain a predominant 68,000-dalton polypeptide. This polypeptide is also a major component of the neurofilaments that copurify with brain tubulin isolated by ...
Asai, David J.   +2 more
core  

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